Biomarkers to Predict DMARDs Efficacy and Adverse Effect in Rheumatoid Arthritis
Rheumatoid arthritis (RA), one of the most common immune system diseases, mainly affects middle-aged and elderly individuals and has a serious impact on the quality of life of patients. Pain and disability caused by RA are significant symptoms negatively affecting patients, and they are especially s...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-03-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.865267/full |
| _version_ | 1818394170205667328 |
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| author | Kai Wei Kai Wei Kai Wei Ping Jiang Ping Jiang Ping Jiang Jianan Zhao Jianan Zhao Jianan Zhao Yehua Jin Yehua Jin Yehua Jin Runrun Zhang Runrun Zhang Runrun Zhang Cen Chang Cen Chang Cen Chang Lingxia Xu Lingxia Xu Lingxia Xu Linshuai Xu Linshuai Xu Linshuai Xu Yiming Shi Yiming Shi Yiming Shi Shicheng Guo Shicheng Guo Dongyi He Dongyi He Dongyi He |
| author_facet | Kai Wei Kai Wei Kai Wei Ping Jiang Ping Jiang Ping Jiang Jianan Zhao Jianan Zhao Jianan Zhao Yehua Jin Yehua Jin Yehua Jin Runrun Zhang Runrun Zhang Runrun Zhang Cen Chang Cen Chang Cen Chang Lingxia Xu Lingxia Xu Lingxia Xu Linshuai Xu Linshuai Xu Linshuai Xu Yiming Shi Yiming Shi Yiming Shi Shicheng Guo Shicheng Guo Dongyi He Dongyi He Dongyi He |
| author_sort | Kai Wei |
| collection | DOAJ |
| description | Rheumatoid arthritis (RA), one of the most common immune system diseases, mainly affects middle-aged and elderly individuals and has a serious impact on the quality of life of patients. Pain and disability caused by RA are significant symptoms negatively affecting patients, and they are especially seen when inappropriate treatment is administered. Effective therapeutic strategies have evolved over the past few decades, with many new disease-modifying antirheumatic drugs (DMARDs) being used in the clinic. Owing to the breakthrough in the treatment of RA, the symptoms of patients who could not be treated effectively in the past few years have been relieved. However, some patients complain about symptoms that have not been reported, implying that there are still some limitations in the RA treatment and evaluation system. In recent years, biomarkers, an effective means of diagnosing and evaluating the condition of patients with RA, have gradually been used in clinical practice to evaluate the therapeutic effect of RA, which is constantly being improved for accurate application of treatment in patients with RA. In this article, we summarize a series of biomarkers that may be helpful in evaluating the therapeutic effect and improving the efficiency of clinical treatment for RA. These efforts may also encourage researchers to devote more time and resources to the study and application of biomarkers, resulting in a new evaluation system that will reduce the inappropriate use of DMARDs, as well as patients’ physical pain and financial burden. |
| first_indexed | 2024-12-14T05:56:57Z |
| format | Article |
| id | doaj.art-1e273985797343548527cb3254043a36 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-14T05:56:57Z |
| publishDate | 2022-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-1e273985797343548527cb3254043a362022-12-21T23:14:32ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-03-011310.3389/fimmu.2022.865267865267Biomarkers to Predict DMARDs Efficacy and Adverse Effect in Rheumatoid ArthritisKai Wei0Kai Wei1Kai Wei2Ping Jiang3Ping Jiang4Ping Jiang5Jianan Zhao6Jianan Zhao7Jianan Zhao8Yehua Jin9Yehua Jin10Yehua Jin11Runrun Zhang12Runrun Zhang13Runrun Zhang14Cen Chang15Cen Chang16Cen Chang17Lingxia Xu18Lingxia Xu19Lingxia Xu20Linshuai Xu21Linshuai Xu22Linshuai Xu23Yiming Shi24Yiming Shi25Yiming Shi26Shicheng Guo27Shicheng Guo28Dongyi He29Dongyi He30Dongyi He31Guanghua Clinical Medical College, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Rheumatology, Guanghua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaArthritis Institute of Integrated Traditional and Western Medicine, Shanghai Chinese Medicine Research Institute, Shanghai, ChinaGuanghua Clinical Medical College, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Rheumatology, Guanghua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaArthritis Institute of Integrated Traditional and Western Medicine, Shanghai Chinese Medicine Research Institute, Shanghai, ChinaGuanghua Clinical Medical College, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Rheumatology, Guanghua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaArthritis Institute of Integrated Traditional and Western Medicine, Shanghai Chinese Medicine Research Institute, Shanghai, ChinaGuanghua Clinical Medical College, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Rheumatology, Guanghua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaArthritis Institute of Integrated Traditional and Western Medicine, Shanghai Chinese Medicine Research Institute, Shanghai, ChinaGuanghua Clinical Medical College, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaArthritis Institute of Integrated Traditional and Western Medicine, Shanghai Chinese Medicine Research Institute, Shanghai, ChinaThe Second Affiliated Hospital of the Shandong University of Traditional Chinese Medicine, Jinan, ChinaGuanghua Clinical Medical College, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Rheumatology, Guanghua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaArthritis Institute of Integrated Traditional and Western Medicine, Shanghai Chinese Medicine Research Institute, Shanghai, ChinaGuanghua Clinical Medical College, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Rheumatology, Guanghua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaArthritis Institute of Integrated Traditional and Western Medicine, Shanghai Chinese Medicine Research Institute, Shanghai, ChinaGuanghua Clinical Medical College, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Rheumatology, Guanghua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaArthritis Institute of Integrated Traditional and Western Medicine, Shanghai Chinese Medicine Research Institute, Shanghai, ChinaGuanghua Clinical Medical College, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Rheumatology, Guanghua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaArthritis Institute of Integrated Traditional and Western Medicine, Shanghai Chinese Medicine Research Institute, Shanghai, ChinaCenter for Precision Medicine Research, Marshfield Clinic Research Institute, Marshfield, WI, United StatesDepartment of Medical Genetics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, United StatesGuanghua Clinical Medical College, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Rheumatology, Guanghua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaArthritis Institute of Integrated Traditional and Western Medicine, Shanghai Chinese Medicine Research Institute, Shanghai, ChinaRheumatoid arthritis (RA), one of the most common immune system diseases, mainly affects middle-aged and elderly individuals and has a serious impact on the quality of life of patients. Pain and disability caused by RA are significant symptoms negatively affecting patients, and they are especially seen when inappropriate treatment is administered. Effective therapeutic strategies have evolved over the past few decades, with many new disease-modifying antirheumatic drugs (DMARDs) being used in the clinic. Owing to the breakthrough in the treatment of RA, the symptoms of patients who could not be treated effectively in the past few years have been relieved. However, some patients complain about symptoms that have not been reported, implying that there are still some limitations in the RA treatment and evaluation system. In recent years, biomarkers, an effective means of diagnosing and evaluating the condition of patients with RA, have gradually been used in clinical practice to evaluate the therapeutic effect of RA, which is constantly being improved for accurate application of treatment in patients with RA. In this article, we summarize a series of biomarkers that may be helpful in evaluating the therapeutic effect and improving the efficiency of clinical treatment for RA. These efforts may also encourage researchers to devote more time and resources to the study and application of biomarkers, resulting in a new evaluation system that will reduce the inappropriate use of DMARDs, as well as patients’ physical pain and financial burden.https://www.frontiersin.org/articles/10.3389/fimmu.2022.865267/fullrheumatoid arthritistherapybiomarkerDMARDsresponsenonresponse |
| spellingShingle | Kai Wei Kai Wei Kai Wei Ping Jiang Ping Jiang Ping Jiang Jianan Zhao Jianan Zhao Jianan Zhao Yehua Jin Yehua Jin Yehua Jin Runrun Zhang Runrun Zhang Runrun Zhang Cen Chang Cen Chang Cen Chang Lingxia Xu Lingxia Xu Lingxia Xu Linshuai Xu Linshuai Xu Linshuai Xu Yiming Shi Yiming Shi Yiming Shi Shicheng Guo Shicheng Guo Dongyi He Dongyi He Dongyi He Biomarkers to Predict DMARDs Efficacy and Adverse Effect in Rheumatoid Arthritis Frontiers in Immunology rheumatoid arthritis therapy biomarker DMARDs response nonresponse |
| title | Biomarkers to Predict DMARDs Efficacy and Adverse Effect in Rheumatoid Arthritis |
| title_full | Biomarkers to Predict DMARDs Efficacy and Adverse Effect in Rheumatoid Arthritis |
| title_fullStr | Biomarkers to Predict DMARDs Efficacy and Adverse Effect in Rheumatoid Arthritis |
| title_full_unstemmed | Biomarkers to Predict DMARDs Efficacy and Adverse Effect in Rheumatoid Arthritis |
| title_short | Biomarkers to Predict DMARDs Efficacy and Adverse Effect in Rheumatoid Arthritis |
| title_sort | biomarkers to predict dmards efficacy and adverse effect in rheumatoid arthritis |
| topic | rheumatoid arthritis therapy biomarker DMARDs response nonresponse |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.865267/full |
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