Impact of pre‐therapy glioblastoma multiforme microenvironment on clinical response to autologous CMV‐specific T‐cell therapy

Impact of pre‐therapy glioblastoma multiforme microenvironment on clinical response to autologous CMV‐specific T‐cell therapy

Abstract Objectives Clinical response to antibody‐based immunotherapies targeting checkpoint inhibitors is critically dependent on the tumor immune microenvironment (TIME). However, the precise impact of the TIME on adoptive cellular immunotherapy remains unexplored. Here we have conducted a long‐te...

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Bibliographic Details
Main Authors: David G Walker, Reshma Shakya, Beth Morrison, Michelle A Neller, Katherine K Matthews, John Nicholls, Corey Smith, Rajiv Khanna
Format: Article
Language:English
Published: Wiley 2019-01-01
Series:Clinical & Translational Immunology
Subjects:
adoptive immunotherapy
cytomegalovirus (CMV)
glioblastoma multiforme
tumor microenvironment
Online Access:https://doi.org/10.1002/cti2.1088

Internet

https://doi.org/10.1002/cti2.1088

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