ADAM33, a new candidate for psoriasis susceptibility.
Psoriasis is a chronic skin disorder with multifactorial etiology. In a recent study, we reported results of a genome-wide scan on 46 French extended families presenting with plaque psoriasis. In addition to unambiguous linkage to the major susceptibility locus PSORS1 on Chromosome 6p21, we provided...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2007-09-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0000906 |
| _version_ | 1819123270540066816 |
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| author | Fabienne Lesueur Tiphaine Oudot Simon Heath Mario Foglio Mark Lathrop Jean-François Prud'homme Judith Fischer |
| author_facet | Fabienne Lesueur Tiphaine Oudot Simon Heath Mario Foglio Mark Lathrop Jean-François Prud'homme Judith Fischer |
| author_sort | Fabienne Lesueur |
| collection | DOAJ |
| description | Psoriasis is a chronic skin disorder with multifactorial etiology. In a recent study, we reported results of a genome-wide scan on 46 French extended families presenting with plaque psoriasis. In addition to unambiguous linkage to the major susceptibility locus PSORS1 on Chromosome 6p21, we provided evidence for a susceptibility locus on Chromosome 20p13. To follow up this novel psoriasis susceptibility locus we used a family-based association test (FBAT) for an association scan over the 17 Mb candidate region. A total of 85 uncorrelated SNP markers located in 65 genes of the region were initially investigated in the same set of large families used for the genome wide search, which consisted of 295 nuclear families. When positive association was obtained for a SNP, candidate genes nearby were explored more in detail using a denser set of SNPs. Thus, the gene ADAM33 was found to be significantly associated with psoriasis in this family set (The best association was on a 3-SNP haplotype P = 0.00004, based on 1,000,000 permutations). This association was independent of PSORS1. ADAM33 has been previously associated with asthma, which demonstrates that immune system diseases may be controlled by common susceptibility genes with general effects on dermal inflammation and immunity. The identification of ADAM33 as a psoriasis susceptibility gene identified by positional cloning in an outbred population should provide insights into the pathogenesis and natural history of this common disease. |
| first_indexed | 2024-12-22T07:05:41Z |
| format | Article |
| id | doaj.art-1e276bc6a76f4ceda6c9659a20c3c3b2 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-22T07:05:41Z |
| publishDate | 2007-09-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-1e276bc6a76f4ceda6c9659a20c3c3b22022-12-21T18:34:40ZengPublic Library of Science (PLoS)PLoS ONE1932-62032007-09-0129e90610.1371/journal.pone.0000906ADAM33, a new candidate for psoriasis susceptibility.Fabienne LesueurTiphaine OudotSimon HeathMario FoglioMark LathropJean-François Prud'hommeJudith FischerPsoriasis is a chronic skin disorder with multifactorial etiology. In a recent study, we reported results of a genome-wide scan on 46 French extended families presenting with plaque psoriasis. In addition to unambiguous linkage to the major susceptibility locus PSORS1 on Chromosome 6p21, we provided evidence for a susceptibility locus on Chromosome 20p13. To follow up this novel psoriasis susceptibility locus we used a family-based association test (FBAT) for an association scan over the 17 Mb candidate region. A total of 85 uncorrelated SNP markers located in 65 genes of the region were initially investigated in the same set of large families used for the genome wide search, which consisted of 295 nuclear families. When positive association was obtained for a SNP, candidate genes nearby were explored more in detail using a denser set of SNPs. Thus, the gene ADAM33 was found to be significantly associated with psoriasis in this family set (The best association was on a 3-SNP haplotype P = 0.00004, based on 1,000,000 permutations). This association was independent of PSORS1. ADAM33 has been previously associated with asthma, which demonstrates that immune system diseases may be controlled by common susceptibility genes with general effects on dermal inflammation and immunity. The identification of ADAM33 as a psoriasis susceptibility gene identified by positional cloning in an outbred population should provide insights into the pathogenesis and natural history of this common disease.https://doi.org/10.1371/journal.pone.0000906 |
| spellingShingle | Fabienne Lesueur Tiphaine Oudot Simon Heath Mario Foglio Mark Lathrop Jean-François Prud'homme Judith Fischer ADAM33, a new candidate for psoriasis susceptibility. PLoS ONE |
| title | ADAM33, a new candidate for psoriasis susceptibility. |
| title_full | ADAM33, a new candidate for psoriasis susceptibility. |
| title_fullStr | ADAM33, a new candidate for psoriasis susceptibility. |
| title_full_unstemmed | ADAM33, a new candidate for psoriasis susceptibility. |
| title_short | ADAM33, a new candidate for psoriasis susceptibility. |
| title_sort | adam33 a new candidate for psoriasis susceptibility |
| url | https://doi.org/10.1371/journal.pone.0000906 |
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