The Efficacy of Stem Cells in Wound Healing: A Systematic Review
Wound healing is an intricate process involving coordinated interactions among inflammatory cells, skin fibroblasts, keratinocytes, and endothelial cells. Successful tissue repair hinges on controlled inflammation, angiogenesis, and remodeling facilitated by the exchange of cytokines and growth fact...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-03-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/25/5/3006 |
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| author | Banu Farabi Katie Roster Rahim Hirani Katharine Tepper Mehmet Fatih Atak Bijan Safai |
| author_facet | Banu Farabi Katie Roster Rahim Hirani Katharine Tepper Mehmet Fatih Atak Bijan Safai |
| author_sort | Banu Farabi |
| collection | DOAJ |
| description | Wound healing is an intricate process involving coordinated interactions among inflammatory cells, skin fibroblasts, keratinocytes, and endothelial cells. Successful tissue repair hinges on controlled inflammation, angiogenesis, and remodeling facilitated by the exchange of cytokines and growth factors. Comorbid conditions can disrupt this process, leading to significant morbidity and mortality. Stem cell therapy has emerged as a promising strategy for enhancing wound healing, utilizing cells from diverse sources such as endothelial progenitor cells, bone marrow, adipose tissue, dermal, and inducible pluripotent stem cells. In this systematic review, we comprehensively investigated stem cell therapies in chronic wounds, summarizing the clinical, translational, and primary literature. A systematic search across PubMed, Embase, Web of Science, Google Scholar, and Cochrane Library yielded 22,454 articles, reduced to 44 studies after rigorous screening. Notably, adipose tissue-derived mesenchymal stem cells (AD-MSCs) emerged as an optimal choice due to their abundant supply, easy isolation, ex vivo proliferative capacities, and pro-angiogenic factor secretion. AD-MSCs have shown efficacy in various conditions, including peripheral arterial disease, diabetic wounds, hypertensive ulcers, bullous diabeticorum, venous ulcers, and post-Mohs micrographic surgery wounds. Delivery methods varied, encompassing topical application, scaffold incorporation, combination with plasma-rich proteins, and atelocollagen administration. Integration with local wound care practices resulted in reduced pain, shorter healing times, and improved cosmesis. Stem cell transplantation represents a potential therapeutic avenue, as transplanted stem cells not only differentiate into diverse skin cell types but also release essential cytokines and growth factors, fostering increased angiogenesis. This approach holds promise for intractable wounds, particularly chronic lower-leg wounds, and as a post-Mohs micrographic surgery intervention for healing defects through secondary intention. The potential reduction in healthcare costs and enhancement of patient quality of life further underscore the attractiveness of stem cell applications in wound care. This systematic review explores the clinical utilization of stem cells and stem cell products, providing valuable insights into their role as ancillary methods in treating chronic wounds. |
| first_indexed | 2024-04-25T00:27:25Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-04-25T00:27:25Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-1e29313f1ace445ab8490dae1abdf83e2024-03-12T16:47:13ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672024-03-01255300610.3390/ijms25053006The Efficacy of Stem Cells in Wound Healing: A Systematic ReviewBanu Farabi0Katie Roster1Rahim Hirani2Katharine Tepper3Mehmet Fatih Atak4Bijan Safai5Department of Dermatology, New York Medical College, Valhalla, NY 10595, USASchool of Medicine, New York Medical College, Valhalla, NY 10595, USASchool of Medicine, New York Medical College, Valhalla, NY 10595, USAPhillip Capozzi, M.D. Library, New York Medical College, Valhalla, NY 10595, USADepartment of Internal Medicine, NYC H+Health Hospitals/Metropolitan Hospital Center, New York, NY 10029, USADepartment of Dermatology, New York Medical College, Valhalla, NY 10595, USAWound healing is an intricate process involving coordinated interactions among inflammatory cells, skin fibroblasts, keratinocytes, and endothelial cells. Successful tissue repair hinges on controlled inflammation, angiogenesis, and remodeling facilitated by the exchange of cytokines and growth factors. Comorbid conditions can disrupt this process, leading to significant morbidity and mortality. Stem cell therapy has emerged as a promising strategy for enhancing wound healing, utilizing cells from diverse sources such as endothelial progenitor cells, bone marrow, adipose tissue, dermal, and inducible pluripotent stem cells. In this systematic review, we comprehensively investigated stem cell therapies in chronic wounds, summarizing the clinical, translational, and primary literature. A systematic search across PubMed, Embase, Web of Science, Google Scholar, and Cochrane Library yielded 22,454 articles, reduced to 44 studies after rigorous screening. Notably, adipose tissue-derived mesenchymal stem cells (AD-MSCs) emerged as an optimal choice due to their abundant supply, easy isolation, ex vivo proliferative capacities, and pro-angiogenic factor secretion. AD-MSCs have shown efficacy in various conditions, including peripheral arterial disease, diabetic wounds, hypertensive ulcers, bullous diabeticorum, venous ulcers, and post-Mohs micrographic surgery wounds. Delivery methods varied, encompassing topical application, scaffold incorporation, combination with plasma-rich proteins, and atelocollagen administration. Integration with local wound care practices resulted in reduced pain, shorter healing times, and improved cosmesis. Stem cell transplantation represents a potential therapeutic avenue, as transplanted stem cells not only differentiate into diverse skin cell types but also release essential cytokines and growth factors, fostering increased angiogenesis. This approach holds promise for intractable wounds, particularly chronic lower-leg wounds, and as a post-Mohs micrographic surgery intervention for healing defects through secondary intention. The potential reduction in healthcare costs and enhancement of patient quality of life further underscore the attractiveness of stem cell applications in wound care. This systematic review explores the clinical utilization of stem cells and stem cell products, providing valuable insights into their role as ancillary methods in treating chronic wounds.https://www.mdpi.com/1422-0067/25/5/3006stem cellschronic woundwound healingdermatology |
| spellingShingle | Banu Farabi Katie Roster Rahim Hirani Katharine Tepper Mehmet Fatih Atak Bijan Safai The Efficacy of Stem Cells in Wound Healing: A Systematic Review International Journal of Molecular Sciences stem cells chronic wound wound healing dermatology |
| title | The Efficacy of Stem Cells in Wound Healing: A Systematic Review |
| title_full | The Efficacy of Stem Cells in Wound Healing: A Systematic Review |
| title_fullStr | The Efficacy of Stem Cells in Wound Healing: A Systematic Review |
| title_full_unstemmed | The Efficacy of Stem Cells in Wound Healing: A Systematic Review |
| title_short | The Efficacy of Stem Cells in Wound Healing: A Systematic Review |
| title_sort | efficacy of stem cells in wound healing a systematic review |
| topic | stem cells chronic wound wound healing dermatology |
| url | https://www.mdpi.com/1422-0067/25/5/3006 |
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