Association between cytokine profiles and lung injury in COVID-19 pneumonia
Abstract Background Coronavirus disease 2019 (COVID-19) is a new respiratory and systemic disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The purpose of the present study was to investigate the association between cytokine profiles and lung injury in COVID-1...
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| Format: | Article |
| Language: | English |
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BMC
2020-07-01
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| Series: | Respiratory Research |
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| Online Access: | http://link.springer.com/article/10.1186/s12931-020-01465-2 |
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| author | Li-Da Chen Zhen-Yu Zhang Xiao-Jie Wei Yu-Qing Cai Weng-Zhen Yao Ming-Hui Wang Qiu-Fen Huang Xiao-Bin Zhang |
| author_facet | Li-Da Chen Zhen-Yu Zhang Xiao-Jie Wei Yu-Qing Cai Weng-Zhen Yao Ming-Hui Wang Qiu-Fen Huang Xiao-Bin Zhang |
| author_sort | Li-Da Chen |
| collection | DOAJ |
| description | Abstract Background Coronavirus disease 2019 (COVID-19) is a new respiratory and systemic disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The purpose of the present study was to investigate the association between cytokine profiles and lung injury in COVID-19 pneumonia. Methods This retrospective study was conducted in COVID-19 patients. Demographic characteristics, symptoms, signs, underlying diseases, and laboratory data were collected. The patients were divided into COVID-19 with pneumonia and without pneumonia. CT severity score and PaO2/FiO2 ratio were used to assess lung injury. Results 106 patients with 12 COVID-19 without pneumonia and 94 COVID-19 with pneumonia were included. Compared with COVID-19 without pneumonia, COVID-19 with pneumonia had significantly higher serum interleukin (IL)-2R, IL-6, and tumor necrosis factor (TNF)-α. Correlation analysis showed that CT severity score and PaO2/FiO2 were significantly correlated with age, presence of any coexisting disorder, lymphocyte count, procalcitonin, IL-2R, and IL-6. In multivariate analysis, log IL6 was the only independent explanatory variables for CT severity score (β = 0.397, p < 0.001) and PaO2/FiO2 (β = − 0.434, p = 0.003). Conclusions Elevation of circulating cytokines was significantly associated with presence of pneumonia in COVID-19 and the severity of lung injury in COVID-19 pneumonia. Circulating IL-6 independently predicted the severity of lung injury in COVID-19 pneumonia. |
| first_indexed | 2024-12-13T05:38:28Z |
| format | Article |
| id | doaj.art-1e298089e46e4ab8a9ba9f91af12031e |
| institution | Directory Open Access Journal |
| issn | 1465-993X |
| language | English |
| last_indexed | 2024-12-13T05:38:28Z |
| publishDate | 2020-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Respiratory Research |
| spelling | doaj.art-1e298089e46e4ab8a9ba9f91af12031e2022-12-21T23:57:51ZengBMCRespiratory Research1465-993X2020-07-012111810.1186/s12931-020-01465-2Association between cytokine profiles and lung injury in COVID-19 pneumoniaLi-Da Chen0Zhen-Yu Zhang1Xiao-Jie Wei2Yu-Qing Cai3Weng-Zhen Yao4Ming-Hui Wang5Qiu-Fen Huang6Xiao-Bin Zhang7Department of Respiratory and Critical Care Medicine, Zhangzhou Affiliated Hospital of Fujian Medical UniversityDepartment of Geriatrics, Zhongshan Hospital, Xiamen University; Teaching Hospital of Fujian Medical UniversityDepartment of Pulmonary and Critical Care Medicine, Fujian Third People’s HospitalDepartment of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Xiamen University; Teaching Hospital of Fujian Medical UniversityDepartment of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Xiamen University; Teaching Hospital of Fujian Medical UniversityDepartment of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Xiamen University; Teaching Hospital of Fujian Medical UniversityDepartment of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Xiamen University; Teaching Hospital of Fujian Medical UniversityDepartment of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Xiamen University; Teaching Hospital of Fujian Medical UniversityAbstract Background Coronavirus disease 2019 (COVID-19) is a new respiratory and systemic disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The purpose of the present study was to investigate the association between cytokine profiles and lung injury in COVID-19 pneumonia. Methods This retrospective study was conducted in COVID-19 patients. Demographic characteristics, symptoms, signs, underlying diseases, and laboratory data were collected. The patients were divided into COVID-19 with pneumonia and without pneumonia. CT severity score and PaO2/FiO2 ratio were used to assess lung injury. Results 106 patients with 12 COVID-19 without pneumonia and 94 COVID-19 with pneumonia were included. Compared with COVID-19 without pneumonia, COVID-19 with pneumonia had significantly higher serum interleukin (IL)-2R, IL-6, and tumor necrosis factor (TNF)-α. Correlation analysis showed that CT severity score and PaO2/FiO2 were significantly correlated with age, presence of any coexisting disorder, lymphocyte count, procalcitonin, IL-2R, and IL-6. In multivariate analysis, log IL6 was the only independent explanatory variables for CT severity score (β = 0.397, p < 0.001) and PaO2/FiO2 (β = − 0.434, p = 0.003). Conclusions Elevation of circulating cytokines was significantly associated with presence of pneumonia in COVID-19 and the severity of lung injury in COVID-19 pneumonia. Circulating IL-6 independently predicted the severity of lung injury in COVID-19 pneumonia.http://link.springer.com/article/10.1186/s12931-020-01465-2Coronavirus disease 2019Severe acute respiratory syndrome coronavirus 2CytokineLung injuryPneumonia |
| spellingShingle | Li-Da Chen Zhen-Yu Zhang Xiao-Jie Wei Yu-Qing Cai Weng-Zhen Yao Ming-Hui Wang Qiu-Fen Huang Xiao-Bin Zhang Association between cytokine profiles and lung injury in COVID-19 pneumonia Respiratory Research Coronavirus disease 2019 Severe acute respiratory syndrome coronavirus 2 Cytokine Lung injury Pneumonia |
| title | Association between cytokine profiles and lung injury in COVID-19 pneumonia |
| title_full | Association between cytokine profiles and lung injury in COVID-19 pneumonia |
| title_fullStr | Association between cytokine profiles and lung injury in COVID-19 pneumonia |
| title_full_unstemmed | Association between cytokine profiles and lung injury in COVID-19 pneumonia |
| title_short | Association between cytokine profiles and lung injury in COVID-19 pneumonia |
| title_sort | association between cytokine profiles and lung injury in covid 19 pneumonia |
| topic | Coronavirus disease 2019 Severe acute respiratory syndrome coronavirus 2 Cytokine Lung injury Pneumonia |
| url | http://link.springer.com/article/10.1186/s12931-020-01465-2 |
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