Cell therapy as a treatment strategy in amyotrophic lateral sclerosis
Cell therapy and tissue engineering are promising therapeutic strategies for such neurodegenerative diseases as amyotrophic lateral sclerosis (ALS). Studies of different cell types have reported promising yet contradictory results, and the development of biomaterials enabling the integration of exog...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | Neurology Perspectives |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667049621000818 |
| _version_ | 1797526164849295360 |
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| author | L. Moreno-Jiménez M.S. Benito-Martín A. Abad-Fernández B. Selma-Calvo N. Fernandez-Cucho J.A. Matias-Guiu L. Galán-Davila A. Guerrero-Sola U. Gómez-Pinedo J. Matias-Guiu |
| author_facet | L. Moreno-Jiménez M.S. Benito-Martín A. Abad-Fernández B. Selma-Calvo N. Fernandez-Cucho J.A. Matias-Guiu L. Galán-Davila A. Guerrero-Sola U. Gómez-Pinedo J. Matias-Guiu |
| author_sort | L. Moreno-Jiménez |
| collection | DOAJ |
| description | Cell therapy and tissue engineering are promising therapeutic strategies for such neurodegenerative diseases as amyotrophic lateral sclerosis (ALS). Studies of different cell types have reported promising yet contradictory results, and the development of biomaterials enabling the integration of exogenous and host cells has been slow. This review analyses the most promising results published to date and emphasises the need for further research into the clinical application of biomaterials. Resumen: La terapia celular y la ingeniería tisular han dado un paso adelante en el desarrollo de posibles estrategias terapéuticas en enfermedades neurodegenerativas como la Esclerosis Lateral amiotrófica (ELA). Diversos tipos celulares se han ensayado tanto con resultados prometedores como contradictorios, por su parte, el desarrollo de biomateriales que favorezcan la integración de células exógenas en el huésped ha sido lento. La presente revisión pretende, abordar los resultados más prometedores y recordar el camino que aún hay por recorrer en la traslación a la clínica. |
| first_indexed | 2024-03-10T09:25:20Z |
| format | Article |
| id | doaj.art-1e29ab15a09e4dae9114a5595d38e0c1 |
| institution | Directory Open Access Journal |
| issn | 2667-0496 |
| language | English |
| last_indexed | 2024-03-10T09:25:20Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neurology Perspectives |
| spelling | doaj.art-1e29ab15a09e4dae9114a5595d38e0c12023-11-22T04:49:23ZengElsevierNeurology Perspectives2667-04962022-01-012S69S73Cell therapy as a treatment strategy in amyotrophic lateral sclerosisL. Moreno-Jiménez0M.S. Benito-Martín1A. Abad-Fernández2B. Selma-Calvo3N. Fernandez-Cucho4J.A. Matias-Guiu5L. Galán-Davila6A. Guerrero-Sola7U. Gómez-Pinedo8J. Matias-Guiu9Laboratory of Neurobiology, Institute of Neurosciences, Health Research Institute of the Hospital Clínico San Carlos, Universidad Complutense de Madrid, 28040 Madrid, SpainLaboratory of Neurobiology, Institute of Neurosciences, Health Research Institute of the Hospital Clínico San Carlos, Universidad Complutense de Madrid, 28040 Madrid, SpainLaboratory of Neurobiology, Institute of Neurosciences, Health Research Institute of the Hospital Clínico San Carlos, Universidad Complutense de Madrid, 28040 Madrid, SpainLaboratory of Neurobiology, Institute of Neurosciences, Health Research Institute of the Hospital Clínico San Carlos, Universidad Complutense de Madrid, 28040 Madrid, SpainLaboratory of Neurobiology, Institute of Neurosciences, Health Research Institute of the Hospital Clínico San Carlos, Universidad Complutense de Madrid, 28040 Madrid, SpainDepartment of Neurology, Institute of Neurosciences IdISSC, Hospital Clínico San Carlos, Universidad Complutense de Madrid, 28040 Madrid, SpainDepartment of Neurology, Institute of Neurosciences IdISSC, Hospital Clínico San Carlos, Universidad Complutense de Madrid, 28040 Madrid, SpainDepartment of Neurology, Institute of Neurosciences IdISSC, Hospital Clínico San Carlos, Universidad Complutense de Madrid, 28040 Madrid, SpainLaboratory of Neurobiology, Institute of Neurosciences, Health Research Institute of the Hospital Clínico San Carlos, Universidad Complutense de Madrid, 28040 Madrid, Spain; Corresponding author.Laboratory of Neurobiology, Institute of Neurosciences, Health Research Institute of the Hospital Clínico San Carlos, Universidad Complutense de Madrid, 28040 Madrid, Spain; Department of Neurology, Institute of Neurosciences IdISSC, Hospital Clínico San Carlos, Universidad Complutense de Madrid, 28040 Madrid, SpainCell therapy and tissue engineering are promising therapeutic strategies for such neurodegenerative diseases as amyotrophic lateral sclerosis (ALS). Studies of different cell types have reported promising yet contradictory results, and the development of biomaterials enabling the integration of exogenous and host cells has been slow. This review analyses the most promising results published to date and emphasises the need for further research into the clinical application of biomaterials. Resumen: La terapia celular y la ingeniería tisular han dado un paso adelante en el desarrollo de posibles estrategias terapéuticas en enfermedades neurodegenerativas como la Esclerosis Lateral amiotrófica (ELA). Diversos tipos celulares se han ensayado tanto con resultados prometedores como contradictorios, por su parte, el desarrollo de biomateriales que favorezcan la integración de células exógenas en el huésped ha sido lento. La presente revisión pretende, abordar los resultados más prometedores y recordar el camino que aún hay por recorrer en la traslación a la clínica.http://www.sciencedirect.com/science/article/pii/S2667049621000818Células MadreTerapia celularBiomaterialesEnfermedades neurodegenerativasELA |
| spellingShingle | L. Moreno-Jiménez M.S. Benito-Martín A. Abad-Fernández B. Selma-Calvo N. Fernandez-Cucho J.A. Matias-Guiu L. Galán-Davila A. Guerrero-Sola U. Gómez-Pinedo J. Matias-Guiu Cell therapy as a treatment strategy in amyotrophic lateral sclerosis Neurology Perspectives Células Madre Terapia celular Biomateriales Enfermedades neurodegenerativas ELA |
| title | Cell therapy as a treatment strategy in amyotrophic lateral sclerosis |
| title_full | Cell therapy as a treatment strategy in amyotrophic lateral sclerosis |
| title_fullStr | Cell therapy as a treatment strategy in amyotrophic lateral sclerosis |
| title_full_unstemmed | Cell therapy as a treatment strategy in amyotrophic lateral sclerosis |
| title_short | Cell therapy as a treatment strategy in amyotrophic lateral sclerosis |
| title_sort | cell therapy as a treatment strategy in amyotrophic lateral sclerosis |
| topic | Células Madre Terapia celular Biomateriales Enfermedades neurodegenerativas ELA |
| url | http://www.sciencedirect.com/science/article/pii/S2667049621000818 |
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