Molecular disparities in colorectal cancers of White Americans, Alabama African Americans, and Oklahoma American Indians
Abstract In the US, the majority of cancer samples analyzed are from white people, leading to biases in racial and ethnic treatment outcomes. Colorectal cancer (CRC) incidence and mortality rates are high in Alabama African Americans (AAs) and Oklahoma American Indians (AIs). We hypothesized that di...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-08-01
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| Series: | npj Precision Oncology |
| Online Access: | https://doi.org/10.1038/s41698-023-00433-5 |
| _version_ | 1797578440071708672 |
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| author | Hiroshi Y. Yamada Chao Xu Kenneth L. Jones Philip H. O’Neill Madka Venkateshwar Srikanth Chiliveru Hyung-Gyoon Kim Mark Doescher Katherine T. Morris Upender Manne Chinthalapally V. Rao |
| author_facet | Hiroshi Y. Yamada Chao Xu Kenneth L. Jones Philip H. O’Neill Madka Venkateshwar Srikanth Chiliveru Hyung-Gyoon Kim Mark Doescher Katherine T. Morris Upender Manne Chinthalapally V. Rao |
| author_sort | Hiroshi Y. Yamada |
| collection | DOAJ |
| description | Abstract In the US, the majority of cancer samples analyzed are from white people, leading to biases in racial and ethnic treatment outcomes. Colorectal cancer (CRC) incidence and mortality rates are high in Alabama African Americans (AAs) and Oklahoma American Indians (AIs). We hypothesized that differences between racial groups may partially explain these disparities. Thus, we compared transcriptomic profiles of CRCs of Alabama AAs, Oklahoma AIs, and white people from both states. Compared to CRCs of white people, CRCs of AAs showed (a) higher expression of cytokines and vesicle trafficking toward modulated antitumor-immune activity, and (b) lower expression of the ID1/BMP/SMAD axis, IL22RA1, APOBEC3, and Mucins; and AIs had (c) higher expression of PTGS2/COX2 (an NSAID target/pro-oncogenic inflammation) and splicing regulators, and (d) lower tumor suppressor activities (e.g., TOB2, PCGF2, BAP1). Therefore, targeting strategies designed for white CRC patients may be less effective for AAs/AIs. These findings illustrate needs to develop optimized interventions to overcome racial CRC disparities. |
| first_indexed | 2024-03-10T22:21:55Z |
| format | Article |
| id | doaj.art-1e2a6a74e9fe42849e368681427ec2c4 |
| institution | Directory Open Access Journal |
| issn | 2397-768X |
| language | English |
| last_indexed | 2024-03-10T22:21:55Z |
| publishDate | 2023-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Precision Oncology |
| spelling | doaj.art-1e2a6a74e9fe42849e368681427ec2c42023-11-19T12:14:10ZengNature Portfolionpj Precision Oncology2397-768X2023-08-01711710.1038/s41698-023-00433-5Molecular disparities in colorectal cancers of White Americans, Alabama African Americans, and Oklahoma American IndiansHiroshi Y. Yamada0Chao Xu1Kenneth L. Jones2Philip H. O’Neill3Madka Venkateshwar4Srikanth Chiliveru5Hyung-Gyoon Kim6Mark Doescher7Katherine T. Morris8Upender Manne9Chinthalapally V. Rao10Department of Internal Medicine, Hematology/Oncology Section, University of Oklahoma Health Sciences Center (OUHSC)Department of Biostatistics and Epidemiology, Hudson College of Public Health, University of Oklahoma Health Sciences Center (OUHSC)Department of Cell Biology, University of Oklahoma Health Sciences Center (OUHSC)Harold Hamm Diabetes Center, University of Oklahoma Health Sciences Center (OUHSC)Department of Internal Medicine, Hematology/Oncology Section, University of Oklahoma Health Sciences Center (OUHSC)Department of Internal Medicine, Hematology/Oncology Section, University of Oklahoma Health Sciences Center (OUHSC)Department of Pathology, Heersink School of Medicine, University of Alabama at BirminghamCommunity Outreach and Engagement, Stephenson Cancer Center, University of Oklahoma Health Sciences Center (OUHSC)Department of Surgery, University of Oklahoma Health Sciences Center (OUHSC)Department of Pathology, Heersink School of Medicine, University of Alabama at BirminghamDepartment of Internal Medicine, Hematology/Oncology Section, University of Oklahoma Health Sciences Center (OUHSC)Abstract In the US, the majority of cancer samples analyzed are from white people, leading to biases in racial and ethnic treatment outcomes. Colorectal cancer (CRC) incidence and mortality rates are high in Alabama African Americans (AAs) and Oklahoma American Indians (AIs). We hypothesized that differences between racial groups may partially explain these disparities. Thus, we compared transcriptomic profiles of CRCs of Alabama AAs, Oklahoma AIs, and white people from both states. Compared to CRCs of white people, CRCs of AAs showed (a) higher expression of cytokines and vesicle trafficking toward modulated antitumor-immune activity, and (b) lower expression of the ID1/BMP/SMAD axis, IL22RA1, APOBEC3, and Mucins; and AIs had (c) higher expression of PTGS2/COX2 (an NSAID target/pro-oncogenic inflammation) and splicing regulators, and (d) lower tumor suppressor activities (e.g., TOB2, PCGF2, BAP1). Therefore, targeting strategies designed for white CRC patients may be less effective for AAs/AIs. These findings illustrate needs to develop optimized interventions to overcome racial CRC disparities.https://doi.org/10.1038/s41698-023-00433-5 |
| spellingShingle | Hiroshi Y. Yamada Chao Xu Kenneth L. Jones Philip H. O’Neill Madka Venkateshwar Srikanth Chiliveru Hyung-Gyoon Kim Mark Doescher Katherine T. Morris Upender Manne Chinthalapally V. Rao Molecular disparities in colorectal cancers of White Americans, Alabama African Americans, and Oklahoma American Indians npj Precision Oncology |
| title | Molecular disparities in colorectal cancers of White Americans, Alabama African Americans, and Oklahoma American Indians |
| title_full | Molecular disparities in colorectal cancers of White Americans, Alabama African Americans, and Oklahoma American Indians |
| title_fullStr | Molecular disparities in colorectal cancers of White Americans, Alabama African Americans, and Oklahoma American Indians |
| title_full_unstemmed | Molecular disparities in colorectal cancers of White Americans, Alabama African Americans, and Oklahoma American Indians |
| title_short | Molecular disparities in colorectal cancers of White Americans, Alabama African Americans, and Oklahoma American Indians |
| title_sort | molecular disparities in colorectal cancers of white americans alabama african americans and oklahoma american indians |
| url | https://doi.org/10.1038/s41698-023-00433-5 |
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