Computational Screening and Experimental Validation on Multicomponent Crystals of a New Class of Janus Kinase (JAK) Inhibitor Drug with Improved Solubility

Computational Screening and Experimental Validation on Multicomponent Crystals of a New Class of Janus Kinase (JAK) Inhibitor Drug with Improved Solubility

Developing multicomponent crystal forms, especially cocrystals and salts, is becoming a promising pathway to improve the solubility and bioavailability of drugs. Herein, new multicomponent crystals of SHR0302, a new generation of Janus Kinase (JAK) inhibitor that suffers from poor solubility, were d...

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Bibliographic Details
Main Authors: Yujiang Xie, Genpei Shi, Jie Sun, Si Li, Wei Gao, Yimin Hu, Chang Zu, Weiwei Tang, Junbo Gong
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Crystals
Subjects:
multicomponent crystals
cocrystals
COSMO-RS
cocrystal prediction
solubility enhancement
Online Access:https://www.mdpi.com/2073-4352/12/12/1722

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