Serum levels of interleukin-1 (IL-1α, IL-1β) in patients with alopecia areata
Introduction: Alopecia areata (AA) is disease characterized by focally, nonscarring hair loss on the scalp or other parts of the body. It affects 1-2% population of both genders and occurs at all age groups. The etiology is unknown, although most evidence supports the hypothesis that AA is a T-cell-...
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Our Dermatology Online
2012-07-01
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| Series: | Nasza Dermatologia Online |
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| Online Access: | http://www.odermatol.com/wp-content/uploads/file/2012%203/DOI-1.pdf |
| _version_ | 1819238271056609280 |
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| author | Emina Kasumagić-Halilovic Nermina Ovcina-Kurtovic |
| author_facet | Emina Kasumagić-Halilovic Nermina Ovcina-Kurtovic |
| author_sort | Emina Kasumagić-Halilovic |
| collection | DOAJ |
| description | Introduction: Alopecia areata (AA) is disease characterized by focally, nonscarring hair loss on the scalp or other parts of the body. It affects 1-2% population of both genders and occurs at all age groups. The etiology is unknown, although most evidence supports the hypothesis that AA is a T-cell-mediated autoimmune disease of the hair follicle and that cytokines play an important role.Objective: The aim of our study was to evaluate serum concentrations of IL-1α and IL-1β in patients with AA and healthy subjects and also to asses a possible association between these cytokines and duration of the disease.Methods: Forty six patients with AA and 20 healthy controls were enrolled in the study. Serum concentrations of IL-1α and IL-1β were measured using enzyme-linked immunoassay techniques.Results: The serum level of IL-1α in patients with AA was significantly higher than that in the control group (4.34±0.86 pg/mL vs 3.66±0.35 pg/mL, respectively). IL-1β levels were greater in patients with AA than in controls (2.35±0.17 pg/mL vs 2.24±0.30, respectively) but the difference was not significant (p>0.05). No correlations were found between duration of disease and the serum levels of IL-1α and IL-1β.Conclusion: Our results have demonstrated the importance of determining IL-1a concentration in serum in patients with AA. This research could contribute to the interpretation of insufficiently well known views of the pathogenesis role and significance of IL-1α in AA. |
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| id | doaj.art-1e2c370940c544dd8997cbccf5563c91 |
| institution | Directory Open Access Journal |
| issn | 2081-9390 |
| language | English |
| last_indexed | 2024-12-23T13:33:34Z |
| publishDate | 2012-07-01 |
| publisher | Our Dermatology Online |
| record_format | Article |
| series | Nasza Dermatologia Online |
| spelling | doaj.art-1e2c370940c544dd8997cbccf5563c912022-12-21T17:45:05ZengOur Dermatology OnlineNasza Dermatologia Online2081-93902012-07-0133161163Serum levels of interleukin-1 (IL-1α, IL-1β) in patients with alopecia areataEmina Kasumagić-HalilovicNermina Ovcina-KurtovicIntroduction: Alopecia areata (AA) is disease characterized by focally, nonscarring hair loss on the scalp or other parts of the body. It affects 1-2% population of both genders and occurs at all age groups. The etiology is unknown, although most evidence supports the hypothesis that AA is a T-cell-mediated autoimmune disease of the hair follicle and that cytokines play an important role.Objective: The aim of our study was to evaluate serum concentrations of IL-1α and IL-1β in patients with AA and healthy subjects and also to asses a possible association between these cytokines and duration of the disease.Methods: Forty six patients with AA and 20 healthy controls were enrolled in the study. Serum concentrations of IL-1α and IL-1β were measured using enzyme-linked immunoassay techniques.Results: The serum level of IL-1α in patients with AA was significantly higher than that in the control group (4.34±0.86 pg/mL vs 3.66±0.35 pg/mL, respectively). IL-1β levels were greater in patients with AA than in controls (2.35±0.17 pg/mL vs 2.24±0.30, respectively) but the difference was not significant (p>0.05). No correlations were found between duration of disease and the serum levels of IL-1α and IL-1β.Conclusion: Our results have demonstrated the importance of determining IL-1a concentration in serum in patients with AA. This research could contribute to the interpretation of insufficiently well known views of the pathogenesis role and significance of IL-1α in AA.http://www.odermatol.com/wp-content/uploads/file/2012%203/DOI-1.pdfalopecia areatacytokinesinterleukin-1ainterleukin-1β |
| spellingShingle | Emina Kasumagić-Halilovic Nermina Ovcina-Kurtovic Serum levels of interleukin-1 (IL-1α, IL-1β) in patients with alopecia areata Nasza Dermatologia Online alopecia areata cytokines interleukin-1a interleukin-1β |
| title | Serum levels of interleukin-1 (IL-1α, IL-1β) in patients with alopecia areata |
| title_full | Serum levels of interleukin-1 (IL-1α, IL-1β) in patients with alopecia areata |
| title_fullStr | Serum levels of interleukin-1 (IL-1α, IL-1β) in patients with alopecia areata |
| title_full_unstemmed | Serum levels of interleukin-1 (IL-1α, IL-1β) in patients with alopecia areata |
| title_short | Serum levels of interleukin-1 (IL-1α, IL-1β) in patients with alopecia areata |
| title_sort | serum levels of interleukin 1 il 1α il 1β in patients with alopecia areata |
| topic | alopecia areata cytokines interleukin-1a interleukin-1β |
| url | http://www.odermatol.com/wp-content/uploads/file/2012%203/DOI-1.pdf |
| work_keys_str_mv | AT eminakasumagichalilovic serumlevelsofinterleukin1il1ail1binpatientswithalopeciaareata AT nerminaovcinakurtovic serumlevelsofinterleukin1il1ail1binpatientswithalopeciaareata |