Bioelectric Applications for Treatment of Melanoma
Two new cancer therapies apply bioelectric principles. These methods target tumor structures locally and function by applying millisecond electric fields to deliver plasmid DNA encoding cytokines using electrogene transfer (EGT) or by applying rapid rise-time nanosecond pulsed electric fields (nsPEF...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2010-09-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2072-6694/2/3/1731/ |
| _version_ | 1797759167912476672 |
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| author | Richard Heller Karl H. Schoenbach Stephen J. Beebe |
| author_facet | Richard Heller Karl H. Schoenbach Stephen J. Beebe |
| author_sort | Richard Heller |
| collection | DOAJ |
| description | Two new cancer therapies apply bioelectric principles. These methods target tumor structures locally and function by applying millisecond electric fields to deliver plasmid DNA encoding cytokines using electrogene transfer (EGT) or by applying rapid rise-time nanosecond pulsed electric fields (nsPEFs). EGT has been used to locally deliver cytokines such as IL-12 to activate an immune response, resulting in bystander effects. NsPEFs locally induce apoptosis-like effects and affect vascular networks, both promoting tumor demise and restoration of normal vascular homeostasis. EGT with IL-12 is in melanoma clinical trials and nsPEFs are used in models with B16F10 melanoma in vitro and in mice. Applications of bioelectrics, using conventional electroporation and extensions of it, provide effective alternative therapies for melanoma. |
| first_indexed | 2024-03-12T18:40:30Z |
| format | Article |
| id | doaj.art-1e2cea0e83b44683ba2a8cbac5593c3f |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T18:40:30Z |
| publishDate | 2010-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-1e2cea0e83b44683ba2a8cbac5593c3f2023-08-02T07:49:54ZengMDPI AGCancers2072-66942010-09-01231731177010.3390/cancers2031731Bioelectric Applications for Treatment of MelanomaRichard HellerKarl H. SchoenbachStephen J. BeebeTwo new cancer therapies apply bioelectric principles. These methods target tumor structures locally and function by applying millisecond electric fields to deliver plasmid DNA encoding cytokines using electrogene transfer (EGT) or by applying rapid rise-time nanosecond pulsed electric fields (nsPEFs). EGT has been used to locally deliver cytokines such as IL-12 to activate an immune response, resulting in bystander effects. NsPEFs locally induce apoptosis-like effects and affect vascular networks, both promoting tumor demise and restoration of normal vascular homeostasis. EGT with IL-12 is in melanoma clinical trials and nsPEFs are used in models with B16F10 melanoma in vitro and in mice. Applications of bioelectrics, using conventional electroporation and extensions of it, provide effective alternative therapies for melanoma.http://www.mdpi.com/2072-6694/2/3/1731/electric fieldselectroporationgene deliverycytokinesenhanced immunitynanosecond pulsed electric fieldsnon-thermal effectsapoptosiscaspasesanti-angiogenesis |
| spellingShingle | Richard Heller Karl H. Schoenbach Stephen J. Beebe Bioelectric Applications for Treatment of Melanoma Cancers electric fields electroporation gene delivery cytokines enhanced immunity nanosecond pulsed electric fields non-thermal effects apoptosis caspases anti-angiogenesis |
| title | Bioelectric Applications for Treatment of Melanoma |
| title_full | Bioelectric Applications for Treatment of Melanoma |
| title_fullStr | Bioelectric Applications for Treatment of Melanoma |
| title_full_unstemmed | Bioelectric Applications for Treatment of Melanoma |
| title_short | Bioelectric Applications for Treatment of Melanoma |
| title_sort | bioelectric applications for treatment of melanoma |
| topic | electric fields electroporation gene delivery cytokines enhanced immunity nanosecond pulsed electric fields non-thermal effects apoptosis caspases anti-angiogenesis |
| url | http://www.mdpi.com/2072-6694/2/3/1731/ |
| work_keys_str_mv | AT richardheller bioelectricapplicationsfortreatmentofmelanoma AT karlhschoenbach bioelectricapplicationsfortreatmentofmelanoma AT stephenjbeebe bioelectricapplicationsfortreatmentofmelanoma |