The revised recommendation for administering vitamin C in septic patients: the Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2020

The revised recommendation for administering vitamin C in septic patients: the Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2020

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Abstract Given the available clinical evidence through the literature search when the Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2020 was being created, we suggested administering vitamin C to such patients. Recently, several randomized control trials have been p...

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Bibliographic Details
Main Authors: Guideline committee of The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2020, Japanese Society of Intensive Care Medicine, Japanese Association for Acute Medicine
Format: Article
Language:English
Published: BMC 2022-11-01
Series:Journal of Intensive Care
Subjects:
Sepsis
Septic shock
Clinical practice guideline
Vitamin C
Online Access:https://doi.org/10.1186/s40560-022-00641-4
Description
Summary:Abstract Given the available clinical evidence through the literature search when the Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2020 was being created, we suggested administering vitamin C to such patients. Recently, several randomized control trials have been published, some of which suggested the harmful effect of vitamin C in terms of mortality or persistent organ dysfunction. Therefore, we performed updated systematic reviews and meta-analyses. Accordingly, we revised our recommendation as “We suggest against administering vitamin C to septic patients (GRADE 2D: certainty of evidence = “very low”).”
ISSN:2052-0492

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