The revised recommendation for administering vitamin C in septic patients: the Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2020
Abstract Given the available clinical evidence through the literature search when the Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2020 was being created, we suggested administering vitamin C to such patients. Recently, several randomized control trials have been p...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-11-01
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| Series: | Journal of Intensive Care |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40560-022-00641-4 |
| _version_ | 1811190374008356864 |
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| author | Guideline committee of The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2020 Japanese Society of Intensive Care Medicine Japanese Association for Acute Medicine |
| author_facet | Guideline committee of The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2020 Japanese Society of Intensive Care Medicine Japanese Association for Acute Medicine |
| author_sort | Guideline committee of The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2020 |
| collection | DOAJ |
| description | Abstract Given the available clinical evidence through the literature search when the Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2020 was being created, we suggested administering vitamin C to such patients. Recently, several randomized control trials have been published, some of which suggested the harmful effect of vitamin C in terms of mortality or persistent organ dysfunction. Therefore, we performed updated systematic reviews and meta-analyses. Accordingly, we revised our recommendation as “We suggest against administering vitamin C to septic patients (GRADE 2D: certainty of evidence = “very low”).” |
| first_indexed | 2024-04-11T14:49:51Z |
| format | Article |
| id | doaj.art-1e2f92ca68ea46089ac8059757a605e6 |
| institution | Directory Open Access Journal |
| issn | 2052-0492 |
| language | English |
| last_indexed | 2024-04-11T14:49:51Z |
| publishDate | 2022-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Intensive Care |
| spelling | doaj.art-1e2f92ca68ea46089ac8059757a605e62022-12-22T04:17:32ZengBMCJournal of Intensive Care2052-04922022-11-011011410.1186/s40560-022-00641-4The revised recommendation for administering vitamin C in septic patients: the Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2020Guideline committee of The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2020Japanese Society of Intensive Care MedicineJapanese Association for Acute MedicineAbstract Given the available clinical evidence through the literature search when the Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2020 was being created, we suggested administering vitamin C to such patients. Recently, several randomized control trials have been published, some of which suggested the harmful effect of vitamin C in terms of mortality or persistent organ dysfunction. Therefore, we performed updated systematic reviews and meta-analyses. Accordingly, we revised our recommendation as “We suggest against administering vitamin C to septic patients (GRADE 2D: certainty of evidence = “very low”).”https://doi.org/10.1186/s40560-022-00641-4SepsisSeptic shockClinical practice guidelineVitamin C |
| spellingShingle | Guideline committee of The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2020 Japanese Society of Intensive Care Medicine Japanese Association for Acute Medicine The revised recommendation for administering vitamin C in septic patients: the Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2020 Journal of Intensive Care Sepsis Septic shock Clinical practice guideline Vitamin C |
| title | The revised recommendation for administering vitamin C in septic patients: the Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2020 |
| title_full | The revised recommendation for administering vitamin C in septic patients: the Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2020 |
| title_fullStr | The revised recommendation for administering vitamin C in septic patients: the Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2020 |
| title_full_unstemmed | The revised recommendation for administering vitamin C in septic patients: the Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2020 |
| title_short | The revised recommendation for administering vitamin C in septic patients: the Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2020 |
| title_sort | revised recommendation for administering vitamin c in septic patients the japanese clinical practice guidelines for management of sepsis and septic shock 2020 |
| topic | Sepsis Septic shock Clinical practice guideline Vitamin C |
| url | https://doi.org/10.1186/s40560-022-00641-4 |
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