Microwave-Induced In Situ Amorphization: A New Strategy for Tackling the Stability Issue of Amorphous Solid Dispersions

Microwave-Induced In Situ Amorphization: A New Strategy for Tackling the Stability Issue of Amorphous Solid Dispersions

The thermodynamically unstable nature of amorphous drugs has led to a persistent stability issue of amorphous solid dispersions (ASDs). Lately, microwave-induced in situ amorphization has been proposed as a promising solution to this problem, where the originally loaded crystalline drug is in situ a...

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Bibliographic Details
Main Authors: Wei Qiang, Korbinian Löbmann, Colin P. McCoy, Gavin P. Andrews, Min Zhao
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Pharmaceutics
Subjects:
microwave irradiation
amorphous solid dispersions
poorly soluble drugs
in situ amorphization
physical stability
Online Access:https://www.mdpi.com/1999-4923/12/7/655

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