On the influence of the source of porcine colostrum in the development of early immune ontogeny in piglets
Abstract The effects on the ontogeny of serum cytokines and immune cells caused by feeding suckling piglets with sow/gilt colostrum and milk replacer was assessed in the present study. After farrowing, the piglets born were randomized into six groups: GG and SS (n = 10/group): piglets were kept with...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-09-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-20082-1 |
| _version_ | 1811183773885136896 |
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| author | Shaiana Salete Maciag Franciana Volpato Bellaver Gabrielly Bombassaro Vanessa Haach Marcos Antônio Zanella Morés Lana Flávia Baron Arlei Coldebella Ana Paula Bastos |
| author_facet | Shaiana Salete Maciag Franciana Volpato Bellaver Gabrielly Bombassaro Vanessa Haach Marcos Antônio Zanella Morés Lana Flávia Baron Arlei Coldebella Ana Paula Bastos |
| author_sort | Shaiana Salete Maciag |
| collection | DOAJ |
| description | Abstract The effects on the ontogeny of serum cytokines and immune cells caused by feeding suckling piglets with sow/gilt colostrum and milk replacer was assessed in the present study. After farrowing, the piglets born were randomized into six groups: GG and SS (n = 10/group): piglets were kept with their dam; GS (n = 10): piglets were changed from gilts to sows; SG (n = 10): piglets were changed from sows to gilts; GMR (n = 6) and SMR (n = 8): piglets from either gilts or sows were isolated from the dams and were bottle-fed ad libitum with commercial formula milk replacer. The piglets remained in the groups during the first 24 h of life and were later returned to their respective mothers. Serum immunoglobulin concentration and lymphocyte proliferation from the blood, spleen, thymus, and mesenteric lymph node of the piglets were assessed at 24 h and at 28 days of age. Serum cytokine concentrations were measured through a cytokine multiplex assay at 24 h. Overall, piglets suckling on sows (SS and GS) had a higher concentration of serum immunoglobulin at 24 h, which was also associated with a rise in plasma cytokine concentration and greater ability of B and T cells from lymphatic organs and blood mononuclear cells to respond to mitogens. We suggest a bias towards Th1-, Th2-, and Th17-cell polarizing and cytokines during the suckling period, which may be influenced by maternal immunological factors in the colostrum, such as dam parity. All findings suggest sow parity having a possible role, which may contribute to exerting a modulating action on immune response development. |
| first_indexed | 2024-04-11T09:52:37Z |
| format | Article |
| id | doaj.art-1e312239eae74b168b7d43a84b74025c |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-11T09:52:37Z |
| publishDate | 2022-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-1e312239eae74b168b7d43a84b74025c2022-12-22T04:30:45ZengNature PortfolioScientific Reports2045-23222022-09-0112111610.1038/s41598-022-20082-1On the influence of the source of porcine colostrum in the development of early immune ontogeny in pigletsShaiana Salete Maciag0Franciana Volpato Bellaver1Gabrielly Bombassaro2Vanessa Haach3Marcos Antônio Zanella Morés4Lana Flávia Baron5Arlei Coldebella6Ana Paula Bastos7Universidade Estadual do Centro-Oeste do Paraná – Campus CEDETEGInstituto Federal Catarinense – Campus ConcórdiaInstituto Federal Catarinense – Campus ConcórdiaUniversidade Federal Do Rio Grande Do SulEmbrapa Suínos E AvesUniversidade Federal Do Rio Grande Do SulEmbrapa Suínos E AvesUniversidade Estadual do Centro-Oeste do Paraná – Campus CEDETEGAbstract The effects on the ontogeny of serum cytokines and immune cells caused by feeding suckling piglets with sow/gilt colostrum and milk replacer was assessed in the present study. After farrowing, the piglets born were randomized into six groups: GG and SS (n = 10/group): piglets were kept with their dam; GS (n = 10): piglets were changed from gilts to sows; SG (n = 10): piglets were changed from sows to gilts; GMR (n = 6) and SMR (n = 8): piglets from either gilts or sows were isolated from the dams and were bottle-fed ad libitum with commercial formula milk replacer. The piglets remained in the groups during the first 24 h of life and were later returned to their respective mothers. Serum immunoglobulin concentration and lymphocyte proliferation from the blood, spleen, thymus, and mesenteric lymph node of the piglets were assessed at 24 h and at 28 days of age. Serum cytokine concentrations were measured through a cytokine multiplex assay at 24 h. Overall, piglets suckling on sows (SS and GS) had a higher concentration of serum immunoglobulin at 24 h, which was also associated with a rise in plasma cytokine concentration and greater ability of B and T cells from lymphatic organs and blood mononuclear cells to respond to mitogens. We suggest a bias towards Th1-, Th2-, and Th17-cell polarizing and cytokines during the suckling period, which may be influenced by maternal immunological factors in the colostrum, such as dam parity. All findings suggest sow parity having a possible role, which may contribute to exerting a modulating action on immune response development.https://doi.org/10.1038/s41598-022-20082-1 |
| spellingShingle | Shaiana Salete Maciag Franciana Volpato Bellaver Gabrielly Bombassaro Vanessa Haach Marcos Antônio Zanella Morés Lana Flávia Baron Arlei Coldebella Ana Paula Bastos On the influence of the source of porcine colostrum in the development of early immune ontogeny in piglets Scientific Reports |
| title | On the influence of the source of porcine colostrum in the development of early immune ontogeny in piglets |
| title_full | On the influence of the source of porcine colostrum in the development of early immune ontogeny in piglets |
| title_fullStr | On the influence of the source of porcine colostrum in the development of early immune ontogeny in piglets |
| title_full_unstemmed | On the influence of the source of porcine colostrum in the development of early immune ontogeny in piglets |
| title_short | On the influence of the source of porcine colostrum in the development of early immune ontogeny in piglets |
| title_sort | on the influence of the source of porcine colostrum in the development of early immune ontogeny in piglets |
| url | https://doi.org/10.1038/s41598-022-20082-1 |
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