Multivariate analysis of clinicopathological and prognostic significance of miRNA 106b~25 cluster in gastric cancer
Abstract Background miRNA 106b~25 cluster were demonstrated to be an oncogene. In previous study, we had analyzed the diagnostic significance of miRNA 106b~25 based on its carcinogenesis effect. The significance of miRNA 106b~25 for prognosis of gastric cancer were not researched. Methods We applied...
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| Format: | Article |
| Language: | English |
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BMC
2019-07-01
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| Series: | Cancer Cell International |
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| Online Access: | http://link.springer.com/article/10.1186/s12935-019-0918-7 |
| _version_ | 1819023248805855232 |
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| author | Fangxuan Li Jinchao Huang Juntian Liu Wengui Xu Zhiyong Yuan |
| author_facet | Fangxuan Li Jinchao Huang Juntian Liu Wengui Xu Zhiyong Yuan |
| author_sort | Fangxuan Li |
| collection | DOAJ |
| description | Abstract Background miRNA 106b~25 cluster were demonstrated to be an oncogene. In previous study, we had analyzed the diagnostic significance of miRNA 106b~25 based on its carcinogenesis effect. The significance of miRNA 106b~25 for prognosis of gastric cancer were not researched. Methods We applied multivariate analysis of PCA, PLS-DA and Cox Regression for clinicopathological features and survival time to explore the significance of miRNA 106b~25 expression in plasma and cancer tissues for gastric cancer. Results The expression of miRNA 106b, miRNA 93 and miRNA 25 in plasma were positively correlated with their expression in tumor tissues. Via PCA analysis, it was found that miRNA 106b~25 expression in plasma and tumor, T, N and TNM stage were correlated with each other. Via PLS-DA analysis, we identified that T, N and TNM stage were important factors for miRNA 106b~25 expression both in plasma and tumor (all VIP value > 1.2). According to loading weights of variables for the first and second components, it was found that the importance of the miRNA 106b~25s expression carried with the progressed stage of gastric cancer. In the survival analysis, COX regression showed that T stage, plasma miRNA 106b and tumor miRNA 93 were significant risk factors for overall survival [HR: 0.400 (0.205–0.780); P = 0.007; HR: 0.371 (0.142–0.969), P = 0.043; 0.295 (0.134–0.650), P = 0.002]. Conclusion Plasma and tumor miRNA 106b~25 expression correlated with T, N and TNM stage. Increased miRNA 106b~25 expression was important characters carried with gastric cancer progression. T stage, plasma miRNA106b and tumor miRNA 93 significant risk factors for overall survival. |
| first_indexed | 2024-12-21T04:35:53Z |
| format | Article |
| id | doaj.art-1e327b5cc87d4da2b30b66942a3fc7c7 |
| institution | Directory Open Access Journal |
| issn | 1475-2867 |
| language | English |
| last_indexed | 2024-12-21T04:35:53Z |
| publishDate | 2019-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Cancer Cell International |
| spelling | doaj.art-1e327b5cc87d4da2b30b66942a3fc7c72022-12-21T19:15:51ZengBMCCancer Cell International1475-28672019-07-0119111010.1186/s12935-019-0918-7Multivariate analysis of clinicopathological and prognostic significance of miRNA 106b~25 cluster in gastric cancerFangxuan Li0Jinchao Huang1Juntian Liu2Wengui Xu3Zhiyong Yuan4Department of Radiotherapy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and TherapyDepartment of Cancer Prevention, Tianjin Medical University Cancer Institute and HospitalDepartment of Cancer Prevention, Tianjin Medical University Cancer Institute and HospitalDepartment of Molecular Imaging and Nuclear Medicine, Tianjin Medical University Cancer Institute and HospitalDepartment of Radiotherapy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and TherapyAbstract Background miRNA 106b~25 cluster were demonstrated to be an oncogene. In previous study, we had analyzed the diagnostic significance of miRNA 106b~25 based on its carcinogenesis effect. The significance of miRNA 106b~25 for prognosis of gastric cancer were not researched. Methods We applied multivariate analysis of PCA, PLS-DA and Cox Regression for clinicopathological features and survival time to explore the significance of miRNA 106b~25 expression in plasma and cancer tissues for gastric cancer. Results The expression of miRNA 106b, miRNA 93 and miRNA 25 in plasma were positively correlated with their expression in tumor tissues. Via PCA analysis, it was found that miRNA 106b~25 expression in plasma and tumor, T, N and TNM stage were correlated with each other. Via PLS-DA analysis, we identified that T, N and TNM stage were important factors for miRNA 106b~25 expression both in plasma and tumor (all VIP value > 1.2). According to loading weights of variables for the first and second components, it was found that the importance of the miRNA 106b~25s expression carried with the progressed stage of gastric cancer. In the survival analysis, COX regression showed that T stage, plasma miRNA 106b and tumor miRNA 93 were significant risk factors for overall survival [HR: 0.400 (0.205–0.780); P = 0.007; HR: 0.371 (0.142–0.969), P = 0.043; 0.295 (0.134–0.650), P = 0.002]. Conclusion Plasma and tumor miRNA 106b~25 expression correlated with T, N and TNM stage. Increased miRNA 106b~25 expression was important characters carried with gastric cancer progression. T stage, plasma miRNA106b and tumor miRNA 93 significant risk factors for overall survival.http://link.springer.com/article/10.1186/s12935-019-0918-7miRNA 106bmiRNA 93miRNA 25Gastric cancerPCAPLS-DA |
| spellingShingle | Fangxuan Li Jinchao Huang Juntian Liu Wengui Xu Zhiyong Yuan Multivariate analysis of clinicopathological and prognostic significance of miRNA 106b~25 cluster in gastric cancer Cancer Cell International miRNA 106b miRNA 93 miRNA 25 Gastric cancer PCA PLS-DA |
| title | Multivariate analysis of clinicopathological and prognostic significance of miRNA 106b~25 cluster in gastric cancer |
| title_full | Multivariate analysis of clinicopathological and prognostic significance of miRNA 106b~25 cluster in gastric cancer |
| title_fullStr | Multivariate analysis of clinicopathological and prognostic significance of miRNA 106b~25 cluster in gastric cancer |
| title_full_unstemmed | Multivariate analysis of clinicopathological and prognostic significance of miRNA 106b~25 cluster in gastric cancer |
| title_short | Multivariate analysis of clinicopathological and prognostic significance of miRNA 106b~25 cluster in gastric cancer |
| title_sort | multivariate analysis of clinicopathological and prognostic significance of mirna 106b 25 cluster in gastric cancer |
| topic | miRNA 106b miRNA 93 miRNA 25 Gastric cancer PCA PLS-DA |
| url | http://link.springer.com/article/10.1186/s12935-019-0918-7 |
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