Human thirst behavior requires transformation of sensory inputs by intrinsic brain networks
Abstract Background To survive and thrive, many animals, including humans, have evolved goal-directed behaviors that can respond to specific physiological needs. An example is thirst, where the physiological need to maintain water balance drives the behavioral basic instinct to drink. Determining th...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-11-01
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| Series: | BMC Biology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12915-022-01446-5 |
| _version_ | 1811225166378696704 |
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| author | Li-Ming Hsu Jen-Tsung Yang Xuyun Wen Xia Liang Leng-Chieh Lin Yen-Chu Huang Yuan-Hsiung Tsai |
| author_facet | Li-Ming Hsu Jen-Tsung Yang Xuyun Wen Xia Liang Leng-Chieh Lin Yen-Chu Huang Yuan-Hsiung Tsai |
| author_sort | Li-Ming Hsu |
| collection | DOAJ |
| description | Abstract Background To survive and thrive, many animals, including humans, have evolved goal-directed behaviors that can respond to specific physiological needs. An example is thirst, where the physiological need to maintain water balance drives the behavioral basic instinct to drink. Determining the neural basis of such behaviors, including thirst response, can provide insights into the way brain-wide systems transform sensory inputs into behavioral outputs. However, the neural basis underlying this spontaneous behavior remains unclear. Here, we provide a model of the neural basis of human thirst behavior. Results We used fMRI, coupled with functional connectivity analysis and serial-multiple mediation analysis, we found that the physiological need for water is first detected by the median preoptic nucleus (MnPO), which then regulates the intention of drinking via serial large-scale spontaneous thought-related intrinsic network interactions that include the default mode network, salience network, and frontal-parietal control network. Conclusions Our study demonstrates that the transformation in humans of sensory inputs for a single physiological need, such as to maintain water balance, requires large-scale intrinsic brain networks to transform this input into a spontaneous human behavioral response. |
| first_indexed | 2024-04-12T09:02:18Z |
| format | Article |
| id | doaj.art-1e3305051e464e17b37a82a64a61c1e4 |
| institution | Directory Open Access Journal |
| issn | 1741-7007 |
| language | English |
| last_indexed | 2024-04-12T09:02:18Z |
| publishDate | 2022-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Biology |
| spelling | doaj.art-1e3305051e464e17b37a82a64a61c1e42022-12-22T03:39:11ZengBMCBMC Biology1741-70072022-11-0120111410.1186/s12915-022-01446-5Human thirst behavior requires transformation of sensory inputs by intrinsic brain networksLi-Ming Hsu0Jen-Tsung Yang1Xuyun Wen2Xia Liang3Leng-Chieh Lin4Yen-Chu Huang5Yuan-Hsiung Tsai6Center for Animal Magnetic Resonance Imaging, The University of North Carolina at Chapel HillDepartment of Neurosurgery, Chang Gung Memorial Hospital, ChiayiCollege of Computer Science and Technology, Nanjing University of Aeronautics and AstronauticsLaboratory for Space Environment and Physical Sciences, Institute of TechnologyDepartment of Emergency Medicine, Chang Gung Memorial Hospital, ChiayiDepartment of Neurology, Chang Gung Memorial Hospital, ChiayiDepartment of Diagnostic Radiology, Chang Gung Memorial Hospital, ChiayiAbstract Background To survive and thrive, many animals, including humans, have evolved goal-directed behaviors that can respond to specific physiological needs. An example is thirst, where the physiological need to maintain water balance drives the behavioral basic instinct to drink. Determining the neural basis of such behaviors, including thirst response, can provide insights into the way brain-wide systems transform sensory inputs into behavioral outputs. However, the neural basis underlying this spontaneous behavior remains unclear. Here, we provide a model of the neural basis of human thirst behavior. Results We used fMRI, coupled with functional connectivity analysis and serial-multiple mediation analysis, we found that the physiological need for water is first detected by the median preoptic nucleus (MnPO), which then regulates the intention of drinking via serial large-scale spontaneous thought-related intrinsic network interactions that include the default mode network, salience network, and frontal-parietal control network. Conclusions Our study demonstrates that the transformation in humans of sensory inputs for a single physiological need, such as to maintain water balance, requires large-scale intrinsic brain networks to transform this input into a spontaneous human behavioral response.https://doi.org/10.1186/s12915-022-01446-5Thirst behaviorIntrinsic networkFunctional MRI |
| spellingShingle | Li-Ming Hsu Jen-Tsung Yang Xuyun Wen Xia Liang Leng-Chieh Lin Yen-Chu Huang Yuan-Hsiung Tsai Human thirst behavior requires transformation of sensory inputs by intrinsic brain networks BMC Biology Thirst behavior Intrinsic network Functional MRI |
| title | Human thirst behavior requires transformation of sensory inputs by intrinsic brain networks |
| title_full | Human thirst behavior requires transformation of sensory inputs by intrinsic brain networks |
| title_fullStr | Human thirst behavior requires transformation of sensory inputs by intrinsic brain networks |
| title_full_unstemmed | Human thirst behavior requires transformation of sensory inputs by intrinsic brain networks |
| title_short | Human thirst behavior requires transformation of sensory inputs by intrinsic brain networks |
| title_sort | human thirst behavior requires transformation of sensory inputs by intrinsic brain networks |
| topic | Thirst behavior Intrinsic network Functional MRI |
| url | https://doi.org/10.1186/s12915-022-01446-5 |
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