Extrapulmonary tuberculosis in China: a national survey
Objectives: Extrapulmonary tuberculosis (EPTB) is not a notifiable infectious disease in China but is a heavy burden on public health. However, the epidemic situation of EPTB nationwide is unclear. This study aimed to investigate the magnitude and main subtypes of EPTB in China. Methods: We conducte...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-03-01
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| Series: | International Journal of Infectious Diseases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971222006452 |
| _version_ | 1797897278383456256 |
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| author | Tao Li Xiangyu Yan Xin Du Fei Huang Ni Wang Ni Ni Jingjuan Ren Yanlin Zhao Zhongwei Jia |
| author_facet | Tao Li Xiangyu Yan Xin Du Fei Huang Ni Wang Ni Ni Jingjuan Ren Yanlin Zhao Zhongwei Jia |
| author_sort | Tao Li |
| collection | DOAJ |
| description | Objectives: Extrapulmonary tuberculosis (EPTB) is not a notifiable infectious disease in China but is a heavy burden on public health. However, the epidemic situation of EPTB nationwide is unclear. This study aimed to investigate the magnitude and main subtypes of EPTB in China. Methods: We conducted a national cross-sectional study with multistage, stratified cluster random sampling during 2020-2021. We calculated proportions of EPTB in all patients with TB by organs. Logistic regression models were used to estimate odds ratios by characteristics. Results: A total of 6843 patients with TB were included. Of them, 24.6% were patients with EPTB, and the proportion of EPTB solo was 21.3%. Higher EPTB burden was observed in children, female patients, clinically diagnosed patients, provincial-level and prefectural-level health facilities, and Central and West China. EPTB occurred most frequently in respiratory (35.5%), musculoskeletal (15.8%), and peripheral lymphatic (15.8%) systems with top three subtypes, including tuberculous pleurisy (35.0%), spinal TB (9.8%) and cervical tuberculous lymphadenopathy (7.9%). With the increase of age, proportion of peripheral lymphatic TB decreased, and proportion rank of genitourinary TB rose. Conclusion: It is essential to strengthen the diagnosis and treatment capacity for EPTB in primary medical facilities. EPTB should be added to the National Tuberculosis Program as a notifiable disease. |
| first_indexed | 2024-04-10T07:56:04Z |
| format | Article |
| id | doaj.art-1e3411c810f54363978449fc4061b95d |
| institution | Directory Open Access Journal |
| issn | 1201-9712 |
| language | English |
| last_indexed | 2024-04-10T07:56:04Z |
| publishDate | 2023-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj.art-1e3411c810f54363978449fc4061b95d2023-02-23T04:30:17ZengElsevierInternational Journal of Infectious Diseases1201-97122023-03-011286977Extrapulmonary tuberculosis in China: a national surveyTao Li0Xiangyu Yan1Xin Du2Fei Huang3Ni Wang4Ni Ni5Jingjuan Ren6Yanlin Zhao7Zhongwei Jia8Chinese Center for Disease Control and Prevention, Beijing, China; School of Public Health, Peking University, Beijing, ChinaSchool of Public Health, Peking University, Beijing, ChinaChinese Center for Disease Control and Prevention, Beijing, ChinaChinese Center for Disease Control and Prevention, Beijing, ChinaChinese Center for Disease Control and Prevention, Beijing, ChinaChinese Center for Disease Control and Prevention, Beijing, ChinaChinese Center for Disease Control and Prevention, Beijing, ChinaChinese Center for Disease Control and Prevention, Beijing, China; Corresponding authors.School of Public Health, Peking University, Beijing, China; Center for Intelligent Public Health, Institute for Artificial Intelligence, Peking University, Beijing, China; Center for Drug Abuse Control and Prevention, National Institute of Health Data Science, Peking University, Beijing, China; Corresponding authors.Objectives: Extrapulmonary tuberculosis (EPTB) is not a notifiable infectious disease in China but is a heavy burden on public health. However, the epidemic situation of EPTB nationwide is unclear. This study aimed to investigate the magnitude and main subtypes of EPTB in China. Methods: We conducted a national cross-sectional study with multistage, stratified cluster random sampling during 2020-2021. We calculated proportions of EPTB in all patients with TB by organs. Logistic regression models were used to estimate odds ratios by characteristics. Results: A total of 6843 patients with TB were included. Of them, 24.6% were patients with EPTB, and the proportion of EPTB solo was 21.3%. Higher EPTB burden was observed in children, female patients, clinically diagnosed patients, provincial-level and prefectural-level health facilities, and Central and West China. EPTB occurred most frequently in respiratory (35.5%), musculoskeletal (15.8%), and peripheral lymphatic (15.8%) systems with top three subtypes, including tuberculous pleurisy (35.0%), spinal TB (9.8%) and cervical tuberculous lymphadenopathy (7.9%). With the increase of age, proportion of peripheral lymphatic TB decreased, and proportion rank of genitourinary TB rose. Conclusion: It is essential to strengthen the diagnosis and treatment capacity for EPTB in primary medical facilities. EPTB should be added to the National Tuberculosis Program as a notifiable disease.http://www.sciencedirect.com/science/article/pii/S1201971222006452Extrapulmonary tuberculosisEpidemiologySubtypes: National survey |
| spellingShingle | Tao Li Xiangyu Yan Xin Du Fei Huang Ni Wang Ni Ni Jingjuan Ren Yanlin Zhao Zhongwei Jia Extrapulmonary tuberculosis in China: a national survey International Journal of Infectious Diseases Extrapulmonary tuberculosis Epidemiology Subtypes: National survey |
| title | Extrapulmonary tuberculosis in China: a national survey |
| title_full | Extrapulmonary tuberculosis in China: a national survey |
| title_fullStr | Extrapulmonary tuberculosis in China: a national survey |
| title_full_unstemmed | Extrapulmonary tuberculosis in China: a national survey |
| title_short | Extrapulmonary tuberculosis in China: a national survey |
| title_sort | extrapulmonary tuberculosis in china a national survey |
| topic | Extrapulmonary tuberculosis Epidemiology Subtypes: National survey |
| url | http://www.sciencedirect.com/science/article/pii/S1201971222006452 |
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