PATHOGENESIS OF MALARIA IN TISSUES AND BLOOD
The clinical manifestations of severe malaria are several and occur in different anatomical sites. Both parasite- and host-related factors contribute to the pathogenicity of the severe forms of the disease. Cytoadherence of infected red blood cells to the vascular endothelium of different organs and...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Mattioli1885
2012-10-01
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| Series: | Mediterranean Journal of Hematology and Infectious Diseases |
| Subjects: | |
| Online Access: | http://www.mjhid.org/index.php/mjhid/article/view/338 |
| _version_ | 1819107725649379328 |
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| author | Beatrice Autino Yolanda Corbett Francesco Castelli Donatella Taramelli |
| author_facet | Beatrice Autino Yolanda Corbett Francesco Castelli Donatella Taramelli |
| author_sort | Beatrice Autino |
| collection | DOAJ |
| description | The clinical manifestations of severe malaria are several and occur in different anatomical sites. Both parasite- and host-related factors contribute to the pathogenicity of the severe forms of the disease. Cytoadherence of infected red blood cells to the vascular endothelium of different organs and rosetting are unique features of malaria parasites which are likely to contribute to the vascular damage and the consequent excessive inflammatory/immune response of the host. In addition to cerebral malaria or severe anaemia, which are quite common manifestation of severe malaria, clinical evidences of thrombocytopenia, acute respiratory distress syndrome (ARDS), liver and kidney disease, are reported. In primigravidae from endemic areas, life threatening placental malaria may also be present.
In the following pages, some of the pathogenetic aspects will be briefly reviewed and then data on selected and less frequent manifestation of severe malaria, such as liver or renal failure or ARDS will be discussed |
| first_indexed | 2024-12-22T02:58:36Z |
| format | Article |
| id | doaj.art-1e35602e0f2e43b68a67275317720136 |
| institution | Directory Open Access Journal |
| issn | 2035-3006 |
| language | English |
| last_indexed | 2024-12-22T02:58:36Z |
| publishDate | 2012-10-01 |
| publisher | Mattioli1885 |
| record_format | Article |
| series | Mediterranean Journal of Hematology and Infectious Diseases |
| spelling | doaj.art-1e35602e0f2e43b68a672753177201362022-12-21T18:41:13ZengMattioli1885Mediterranean Journal of Hematology and Infectious Diseases2035-30062012-10-0141e2012061e201206110.4084/mjhid.2012.061230PATHOGENESIS OF MALARIA IN TISSUES AND BLOODBeatrice AutinoYolanda CorbettFrancesco CastelliDonatella TaramelliThe clinical manifestations of severe malaria are several and occur in different anatomical sites. Both parasite- and host-related factors contribute to the pathogenicity of the severe forms of the disease. Cytoadherence of infected red blood cells to the vascular endothelium of different organs and rosetting are unique features of malaria parasites which are likely to contribute to the vascular damage and the consequent excessive inflammatory/immune response of the host. In addition to cerebral malaria or severe anaemia, which are quite common manifestation of severe malaria, clinical evidences of thrombocytopenia, acute respiratory distress syndrome (ARDS), liver and kidney disease, are reported. In primigravidae from endemic areas, life threatening placental malaria may also be present. In the following pages, some of the pathogenetic aspects will be briefly reviewed and then data on selected and less frequent manifestation of severe malaria, such as liver or renal failure or ARDS will be discussedhttp://www.mjhid.org/index.php/mjhid/article/view/338MalariaPathogenesis |
| spellingShingle | Beatrice Autino Yolanda Corbett Francesco Castelli Donatella Taramelli PATHOGENESIS OF MALARIA IN TISSUES AND BLOOD Mediterranean Journal of Hematology and Infectious Diseases Malaria Pathogenesis |
| title | PATHOGENESIS OF MALARIA IN TISSUES AND BLOOD |
| title_full | PATHOGENESIS OF MALARIA IN TISSUES AND BLOOD |
| title_fullStr | PATHOGENESIS OF MALARIA IN TISSUES AND BLOOD |
| title_full_unstemmed | PATHOGENESIS OF MALARIA IN TISSUES AND BLOOD |
| title_short | PATHOGENESIS OF MALARIA IN TISSUES AND BLOOD |
| title_sort | pathogenesis of malaria in tissues and blood |
| topic | Malaria Pathogenesis |
| url | http://www.mjhid.org/index.php/mjhid/article/view/338 |
| work_keys_str_mv | AT beatriceautino pathogenesisofmalariaintissuesandblood AT yolandacorbett pathogenesisofmalariaintissuesandblood AT francescocastelli pathogenesisofmalariaintissuesandblood AT donatellataramelli pathogenesisofmalariaintissuesandblood |