Dysregulation of Mesenchymal Cell Survival Pathways in Severe Fibrotic Lung Disease: The Effect of Nintedanib Therapy

Dysregulation of Mesenchymal Cell Survival Pathways in Severe Fibrotic Lung Disease: The Effect of Nintedanib Therapy

Impaired apoptotic clearance of myofibroblasts can result in the continuous expansion of scar tissue during the persistent injury in the lung. However, the molecular and cellular mechanisms underlying the apoptotic clearance of multiple mesenchymal cells including fibrocytes, fibroblasts and myofibr...

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Bibliographic Details
Main Authors: Rajesh K. Kasam, Geereddy B. Reddy, Anil G. Jegga, Satish K. Madala
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Pharmacology
Subjects:
myofibroblasts
fibrocytes
apoptosis
idiopathic pulmonary fibrosis
nintedanib
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00532/full

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