A Retrospective Survey among SARS-CoV-1 Infected Healthcare Workers after Three Years Post-Infection
Healthcare workers (HCWs) are on the frontline fighting several infectious diseases including SARS-CoV-1 and COVID-19. Coronavirus neutralizing antibodies (nAbs) were recently reported to last for a certain period. The factors affecting nAbs’ existence remain unclear. Here, we retrospectively analyz...
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MDPI AG
2021-08-01
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| Series: | Pathogens |
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| Online Access: | https://www.mdpi.com/2076-0817/10/9/1078 |
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| author | Szu-Wei Huang Aspiro Nayim Urbina Yi-Ming Arthur Chen Sheng-Fan Wang |
| author_facet | Szu-Wei Huang Aspiro Nayim Urbina Yi-Ming Arthur Chen Sheng-Fan Wang |
| author_sort | Szu-Wei Huang |
| collection | DOAJ |
| description | Healthcare workers (HCWs) are on the frontline fighting several infectious diseases including SARS-CoV-1 and COVID-19. Coronavirus neutralizing antibodies (nAbs) were recently reported to last for a certain period. The factors affecting nAbs’ existence remain unclear. Here, we retrospectively analyzed the factors correlating with nAbs’ from SARS-CoV-1 long-term convalescence HCWs in Taiwan. One hundred and thirty SARS-CoV-1 convalescent patients were recruited between August 2006 and March 2007. Blood samples were collected to determine the anti-nucleocapsid (N) and anti-spike (S) antibodies’ existence status and neutralization ability. Neutralization ability was measured using SARS-CoV-1 pseudotyped viruses. Statistical analysis of factors associated with anti-SARS-CoV-1 antibodies’ existence status was determined using SAS software. 46.2% SARS-CoV-1 convalescent patients presented anti-N antibody after three years post-infection. Among sixty participants, ten participants co-presented anti-S antibodies. Eight participants with anti-S antibody displayed neutralization ability to SARS-CoV-1. The gender, age, and disease severity of participants did not affect the anti-N antibody existence status, whereas the anti-S antibody is significantly reduced in participants with old age (>50 years, <i>p</i> = 0.0434) after three years post SARS-CoV-1 infection. This study suggests that age is an important factor correlated with the duration of SARS-CoV-1 protective antibody existence status. |
| first_indexed | 2024-03-10T07:20:00Z |
| format | Article |
| id | doaj.art-1e37cdebc9f04d6ba1db5ad138f9d6b9 |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-03-10T07:20:00Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-1e37cdebc9f04d6ba1db5ad138f9d6b92023-11-22T14:41:22ZengMDPI AGPathogens2076-08172021-08-01109107810.3390/pathogens10091078A Retrospective Survey among SARS-CoV-1 Infected Healthcare Workers after Three Years Post-InfectionSzu-Wei Huang0Aspiro Nayim Urbina1Yi-Ming Arthur Chen2Sheng-Fan Wang3Model Development Section, Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USACenter for Tropical Medicine and Infectious Disease, Kaohsiung Medical University, Kaohsiung 80708, TaiwanGraduate Institute of Biomedical and Pharmaceutical Science, Fu Jen Catholic University, New Taipei City 242062, TaiwanCenter for Tropical Medicine and Infectious Disease, Kaohsiung Medical University, Kaohsiung 80708, TaiwanHealthcare workers (HCWs) are on the frontline fighting several infectious diseases including SARS-CoV-1 and COVID-19. Coronavirus neutralizing antibodies (nAbs) were recently reported to last for a certain period. The factors affecting nAbs’ existence remain unclear. Here, we retrospectively analyzed the factors correlating with nAbs’ from SARS-CoV-1 long-term convalescence HCWs in Taiwan. One hundred and thirty SARS-CoV-1 convalescent patients were recruited between August 2006 and March 2007. Blood samples were collected to determine the anti-nucleocapsid (N) and anti-spike (S) antibodies’ existence status and neutralization ability. Neutralization ability was measured using SARS-CoV-1 pseudotyped viruses. Statistical analysis of factors associated with anti-SARS-CoV-1 antibodies’ existence status was determined using SAS software. 46.2% SARS-CoV-1 convalescent patients presented anti-N antibody after three years post-infection. Among sixty participants, ten participants co-presented anti-S antibodies. Eight participants with anti-S antibody displayed neutralization ability to SARS-CoV-1. The gender, age, and disease severity of participants did not affect the anti-N antibody existence status, whereas the anti-S antibody is significantly reduced in participants with old age (>50 years, <i>p</i> = 0.0434) after three years post SARS-CoV-1 infection. This study suggests that age is an important factor correlated with the duration of SARS-CoV-1 protective antibody existence status.https://www.mdpi.com/2076-0817/10/9/1078COVID-19SARS-CoV-1coronavirusesconvalescentneutralizing antibodies |
| spellingShingle | Szu-Wei Huang Aspiro Nayim Urbina Yi-Ming Arthur Chen Sheng-Fan Wang A Retrospective Survey among SARS-CoV-1 Infected Healthcare Workers after Three Years Post-Infection Pathogens COVID-19 SARS-CoV-1 coronaviruses convalescent neutralizing antibodies |
| title | A Retrospective Survey among SARS-CoV-1 Infected Healthcare Workers after Three Years Post-Infection |
| title_full | A Retrospective Survey among SARS-CoV-1 Infected Healthcare Workers after Three Years Post-Infection |
| title_fullStr | A Retrospective Survey among SARS-CoV-1 Infected Healthcare Workers after Three Years Post-Infection |
| title_full_unstemmed | A Retrospective Survey among SARS-CoV-1 Infected Healthcare Workers after Three Years Post-Infection |
| title_short | A Retrospective Survey among SARS-CoV-1 Infected Healthcare Workers after Three Years Post-Infection |
| title_sort | retrospective survey among sars cov 1 infected healthcare workers after three years post infection |
| topic | COVID-19 SARS-CoV-1 coronaviruses convalescent neutralizing antibodies |
| url | https://www.mdpi.com/2076-0817/10/9/1078 |
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