Tumor-Derived Exosomes and Their Role in Breast Cancer Metastasis
Breast cancer has been the most common cancer in women worldwide, and metastasis is the leading cause of death from breast cancer. Even though the study of breast cancer metastasis has been extensively carried out, the molecular mechanism is still not fully understood, and diagnosis and prognosis ne...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/22/13993 |
| _version_ | 1797465083802025984 |
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| author | Shaojuan Huang Ming Dong Qiang Chen |
| author_facet | Shaojuan Huang Ming Dong Qiang Chen |
| author_sort | Shaojuan Huang |
| collection | DOAJ |
| description | Breast cancer has been the most common cancer in women worldwide, and metastasis is the leading cause of death from breast cancer. Even though the study of breast cancer metastasis has been extensively carried out, the molecular mechanism is still not fully understood, and diagnosis and prognosis need to be improved. Breast cancer metastasis is a complicated process involving multiple physiological changes, and lung, brain, bone and liver are the main metastatic targets. Exosomes are membrane-bound extracellular vesicles that contain secreted cellular constitutes. The biogenesis and functions of exosomes in cancer have been intensively studied, and mounting studies have indicated that exosomes play a crucial role in cancer metastasis. In this review, we summarize recent findings on the role of breast cancer-derived exosomes in metastasis organotropism and discuss the potential promising clinical applications of targeting exosomes as novel strategies for breast cancer diagnosis and therapy. |
| first_indexed | 2024-03-09T18:17:24Z |
| format | Article |
| id | doaj.art-1e385ea9f65049f9bf8159cb6f3bd68c |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T18:17:24Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-1e385ea9f65049f9bf8159cb6f3bd68c2023-11-24T08:36:48ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-11-0123221399310.3390/ijms232213993Tumor-Derived Exosomes and Their Role in Breast Cancer MetastasisShaojuan Huang0Ming Dong1Qiang Chen2Cancer Center, Faculty of Health Sciences, University of Macau, Taipa, Macau SAR, ChinaGuangzhou Laboratory, Guangzhou 510005, ChinaCancer Center, Faculty of Health Sciences, University of Macau, Taipa, Macau SAR, ChinaBreast cancer has been the most common cancer in women worldwide, and metastasis is the leading cause of death from breast cancer. Even though the study of breast cancer metastasis has been extensively carried out, the molecular mechanism is still not fully understood, and diagnosis and prognosis need to be improved. Breast cancer metastasis is a complicated process involving multiple physiological changes, and lung, brain, bone and liver are the main metastatic targets. Exosomes are membrane-bound extracellular vesicles that contain secreted cellular constitutes. The biogenesis and functions of exosomes in cancer have been intensively studied, and mounting studies have indicated that exosomes play a crucial role in cancer metastasis. In this review, we summarize recent findings on the role of breast cancer-derived exosomes in metastasis organotropism and discuss the potential promising clinical applications of targeting exosomes as novel strategies for breast cancer diagnosis and therapy.https://www.mdpi.com/1422-0067/23/22/13993breast cancermetastasisexosomeextracellular vesiclesorganotropism |
| spellingShingle | Shaojuan Huang Ming Dong Qiang Chen Tumor-Derived Exosomes and Their Role in Breast Cancer Metastasis International Journal of Molecular Sciences breast cancer metastasis exosome extracellular vesicles organotropism |
| title | Tumor-Derived Exosomes and Their Role in Breast Cancer Metastasis |
| title_full | Tumor-Derived Exosomes and Their Role in Breast Cancer Metastasis |
| title_fullStr | Tumor-Derived Exosomes and Their Role in Breast Cancer Metastasis |
| title_full_unstemmed | Tumor-Derived Exosomes and Their Role in Breast Cancer Metastasis |
| title_short | Tumor-Derived Exosomes and Their Role in Breast Cancer Metastasis |
| title_sort | tumor derived exosomes and their role in breast cancer metastasis |
| topic | breast cancer metastasis exosome extracellular vesicles organotropism |
| url | https://www.mdpi.com/1422-0067/23/22/13993 |
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