Lyophilization-free proliposomes for sustained release oral delivery of hydrophobic drug (cinnarazine): a comparative study
Cinnarizine is used for the treatment of vestibular disorders. However, its poor solubility limits its clinical uses due to many challenges. Liposomes were utilised to improve the release profile of many poorly soluble drugs. However, liposomes face many stability challenges during the storage perio...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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De Gruyter
2021-05-01
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| Series: | Pharmaceutical Technology in Hospital Pharmacy |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/pthp-2021-0002 |
| _version_ | 1828884136089092096 |
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| author | Abu Abed Omar S. Mulkala Srilikha Sharif Israa Abdin Asma M. Elkordy Amal A. |
| author_facet | Abu Abed Omar S. Mulkala Srilikha Sharif Israa Abdin Asma M. Elkordy Amal A. |
| author_sort | Abu Abed Omar S. |
| collection | DOAJ |
| description | Cinnarizine is used for the treatment of vestibular disorders. However, its poor solubility limits its clinical uses due to many challenges. Liposomes were utilised to improve the release profile of many poorly soluble drugs. However, liposomes face many stability challenges during the storage period. This study aims to develop proliposomes designed for the oral delivery of cinnarizine with enhanced stability characteristics. |
| first_indexed | 2024-12-13T11:02:33Z |
| format | Article |
| id | doaj.art-1e386e7779cc4558bd451ea3b3f6d64d |
| institution | Directory Open Access Journal |
| issn | 2365-2411 2365-242X |
| language | English |
| last_indexed | 2024-12-13T11:02:33Z |
| publishDate | 2021-05-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Pharmaceutical Technology in Hospital Pharmacy |
| spelling | doaj.art-1e386e7779cc4558bd451ea3b3f6d64d2022-12-21T23:49:13ZengDe GruyterPharmaceutical Technology in Hospital Pharmacy2365-24112365-242X2021-05-0161e1067910.1515/pthp-2021-0002Lyophilization-free proliposomes for sustained release oral delivery of hydrophobic drug (cinnarazine): a comparative studyAbu Abed Omar S.0Mulkala Srilikha1Sharif Israa2Abdin Asma M.3Elkordy Amal A.4Department of Health Sciences, Arab American University, Al-Reehan, Ramallah91000, PalestineDepartment of Pharmacy and Wellbeing, University of Sunderland, Sunderland, UKDepartment of Health and Nutrition, Palestine Polytechnic University, Hebron, PalestineDepartment of Pharmacy and Wellbeing, University of Sunderland, Sunderland, UKDepartment of Pharmacy and Wellbeing, University of Sunderland, Sunderland, UKCinnarizine is used for the treatment of vestibular disorders. However, its poor solubility limits its clinical uses due to many challenges. Liposomes were utilised to improve the release profile of many poorly soluble drugs. However, liposomes face many stability challenges during the storage period. This study aims to develop proliposomes designed for the oral delivery of cinnarizine with enhanced stability characteristics.https://doi.org/10.1515/pthp-2021-0002liposomesproliposomeslipid delivery systemscinnarizineoral delivery |
| spellingShingle | Abu Abed Omar S. Mulkala Srilikha Sharif Israa Abdin Asma M. Elkordy Amal A. Lyophilization-free proliposomes for sustained release oral delivery of hydrophobic drug (cinnarazine): a comparative study Pharmaceutical Technology in Hospital Pharmacy liposomes proliposomes lipid delivery systems cinnarizine oral delivery |
| title | Lyophilization-free proliposomes for sustained release oral delivery of hydrophobic drug (cinnarazine): a comparative study |
| title_full | Lyophilization-free proliposomes for sustained release oral delivery of hydrophobic drug (cinnarazine): a comparative study |
| title_fullStr | Lyophilization-free proliposomes for sustained release oral delivery of hydrophobic drug (cinnarazine): a comparative study |
| title_full_unstemmed | Lyophilization-free proliposomes for sustained release oral delivery of hydrophobic drug (cinnarazine): a comparative study |
| title_short | Lyophilization-free proliposomes for sustained release oral delivery of hydrophobic drug (cinnarazine): a comparative study |
| title_sort | lyophilization free proliposomes for sustained release oral delivery of hydrophobic drug cinnarazine a comparative study |
| topic | liposomes proliposomes lipid delivery systems cinnarizine oral delivery |
| url | https://doi.org/10.1515/pthp-2021-0002 |
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