Functional MRI evaluation of cognitive effects of carotid stenosis revascularization
Abstract Introduction Severe internal carotid stenosis, if left untreated, can pose serious risks for ischemic stroke and cognitive impairments. The effects of revascularization on any aspects of cognition, however, are not well understood, as conflicting results are reported, which have mainly been...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-04-01
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| Series: | Brain and Behavior |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/brb3.2512 |
| _version_ | 1827860738181431296 |
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| author | Betty Chinda Kim H Tran Sam Doesburg William Siu George Medvedev S Simon Liang Angela Brooks‐Wilson Xiaowei Song |
| author_facet | Betty Chinda Kim H Tran Sam Doesburg William Siu George Medvedev S Simon Liang Angela Brooks‐Wilson Xiaowei Song |
| author_sort | Betty Chinda |
| collection | DOAJ |
| description | Abstract Introduction Severe internal carotid stenosis, if left untreated, can pose serious risks for ischemic stroke and cognitive impairments. The effects of revascularization on any aspects of cognition, however, are not well understood, as conflicting results are reported, which have mainly been centered on paper‐based cognitive analyses. Here, we summarized and evaluated the publications to date of functional MRI (fMRI) studies that examined the mechanisms of functional brain activation and connectivity as a way to reflect cognitive effects of revascularization on patients with carotid stenosis. Methods A PubMed and Google Scholar (covering the relevant literature until November 1, 2021) search yielded eight original studies of the research line, including seven resting‐state and one task‐based fMRI reports. Results Findings demonstrated treatment‐related alterations in fMRI signal intensity and symmetry level, regional fMRI activation pattern, and functional brain network connectivity. The functional brain changes were associated largely with improvement in cognitive function assessed using standard cognitive test scores. Conclusions These findings support the contribution of fMRI to the understanding of brain functional activation and connectivity changes revealing cognitive effects of revascularization in the management of severe carotid stenosis. The review also highlighted the importance of reproducibility through enhancing experimental designs and cognitive task applications with future research for potential clinical translation. |
| first_indexed | 2024-03-12T13:26:09Z |
| format | Article |
| id | doaj.art-1e3c2342b6ac4ecb910e1ffc8b944464 |
| institution | Directory Open Access Journal |
| issn | 2162-3279 |
| language | English |
| last_indexed | 2024-03-12T13:26:09Z |
| publishDate | 2022-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Brain and Behavior |
| spelling | doaj.art-1e3c2342b6ac4ecb910e1ffc8b9444642023-08-25T04:42:41ZengWileyBrain and Behavior2162-32792022-04-01124n/an/a10.1002/brb3.2512Functional MRI evaluation of cognitive effects of carotid stenosis revascularizationBetty Chinda0Kim H Tran1Sam Doesburg2William Siu3George Medvedev4S Simon Liang5Angela Brooks‐Wilson6Xiaowei Song7Department of Biomedical Physiology & Kinesiology Simon Fraser University Burnaby British Columbia CanadaDepartment of Biomedical Physiology & Kinesiology Simon Fraser University Burnaby British Columbia CanadaDepartment of Biomedical Physiology & Kinesiology Simon Fraser University Burnaby British Columbia CanadaDepartment of Radiology Fraser Health Authority Royal Columbian Hospital New Westminster British Columbia CanadaDepartment of Neurology Fraser Health Authority Royal Columbian Hospital New Westminster British Columbia CanadaDepartment of Medicine University of British Columbia Vancouver British Columbia CanadaDepartment of Biomedical Physiology & Kinesiology Simon Fraser University Burnaby British Columbia CanadaDepartment of Biomedical Physiology & Kinesiology Simon Fraser University Burnaby British Columbia CanadaAbstract Introduction Severe internal carotid stenosis, if left untreated, can pose serious risks for ischemic stroke and cognitive impairments. The effects of revascularization on any aspects of cognition, however, are not well understood, as conflicting results are reported, which have mainly been centered on paper‐based cognitive analyses. Here, we summarized and evaluated the publications to date of functional MRI (fMRI) studies that examined the mechanisms of functional brain activation and connectivity as a way to reflect cognitive effects of revascularization on patients with carotid stenosis. Methods A PubMed and Google Scholar (covering the relevant literature until November 1, 2021) search yielded eight original studies of the research line, including seven resting‐state and one task‐based fMRI reports. Results Findings demonstrated treatment‐related alterations in fMRI signal intensity and symmetry level, regional fMRI activation pattern, and functional brain network connectivity. The functional brain changes were associated largely with improvement in cognitive function assessed using standard cognitive test scores. Conclusions These findings support the contribution of fMRI to the understanding of brain functional activation and connectivity changes revealing cognitive effects of revascularization in the management of severe carotid stenosis. The review also highlighted the importance of reproducibility through enhancing experimental designs and cognitive task applications with future research for potential clinical translation.https://doi.org/10.1002/brb3.2512brain functioncarotid stenosiscognitive functionfunctional MRIrevascularization |
| spellingShingle | Betty Chinda Kim H Tran Sam Doesburg William Siu George Medvedev S Simon Liang Angela Brooks‐Wilson Xiaowei Song Functional MRI evaluation of cognitive effects of carotid stenosis revascularization Brain and Behavior brain function carotid stenosis cognitive function functional MRI revascularization |
| title | Functional MRI evaluation of cognitive effects of carotid stenosis revascularization |
| title_full | Functional MRI evaluation of cognitive effects of carotid stenosis revascularization |
| title_fullStr | Functional MRI evaluation of cognitive effects of carotid stenosis revascularization |
| title_full_unstemmed | Functional MRI evaluation of cognitive effects of carotid stenosis revascularization |
| title_short | Functional MRI evaluation of cognitive effects of carotid stenosis revascularization |
| title_sort | functional mri evaluation of cognitive effects of carotid stenosis revascularization |
| topic | brain function carotid stenosis cognitive function functional MRI revascularization |
| url | https://doi.org/10.1002/brb3.2512 |
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