Shear Wave Elastography in the Diagnosis of Peripheral Neuropathy in Patients With Chronic Kidney Disease Stage 5
ObjectiveTo observe the feasibility of shear wave elastography (SWE) in the diagnosis of peripheral neuropathy in patients undergoing hemodialysis [chronic kidney disease stage 5 dialysis (CKD5D)].MethodsForty patients with CKD5D were divided into a uremic peripheral neuropathy (UPN) group (n = 25)...
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.899822/full |
| _version_ | 1818550052325425152 |
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| author | Xuan Li Haoqi Sun Zhaoguang Zhang Jing Liu Huiying Xu Lin Ma Haibo Zhang Jialin Li Qian Luo Xiangming Wang Min Guo Zhentao Guo Xuexun Chen |
| author_facet | Xuan Li Haoqi Sun Zhaoguang Zhang Jing Liu Huiying Xu Lin Ma Haibo Zhang Jialin Li Qian Luo Xiangming Wang Min Guo Zhentao Guo Xuexun Chen |
| author_sort | Xuan Li |
| collection | DOAJ |
| description | ObjectiveTo observe the feasibility of shear wave elastography (SWE) in the diagnosis of peripheral neuropathy in patients undergoing hemodialysis [chronic kidney disease stage 5 dialysis (CKD5D)].MethodsForty patients with CKD5D were divided into a uremic peripheral neuropathy (UPN) group (n = 25) and a non-UPN group (n = 15) according to the results of a neuro-electrophysiological examination. Sixteen healthy control subjects were also enrolled in this study. Two-dimensional ultrasound examination was conducted, and SWE was then performed to measure Young’s modulus of the tibial nerve. The left and right diameters (D1), anterior and posterior diameters (D2), perimeter (C), cross-sectional area (CSA), and Young’s modulus (E) were measured three times at the same non-entrapment site. The average values were recorded and calculated. The following evaluation indices were also analyzed: sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and area under the receiver operating characteristic curve (AUC).ResultsD1, D2, C, and CSA were not significantly different among the three groups (P > 0.05). However, the difference in the E value among the three groups was statistically significant (P < 0.05). The AUC was 0.889 based on the E value. Using a tibial nerve E value of 48.35 kPa as the cutoff value, the sensitivity, specificity, PPV, and NPV were 86.0%, 84.0%, 81.1%, and 88.1%, respectively.ConclusionsSWE is useful for the diagnosis of peripheral neuropathy in patients with CKD5D. Young’s modulus of 48.35 kPa for the tibial nerve is the optimal cutoff value and has the best diagnostic efficiency for peripheral neuropathy in CKD5D patients. |
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| id | doaj.art-1e3c9774bdc14006a71d60d87aca5a2f |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-12T08:41:18Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-1e3c9774bdc14006a71d60d87aca5a2f2022-12-22T00:30:45ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-06-011310.3389/fendo.2022.899822899822Shear Wave Elastography in the Diagnosis of Peripheral Neuropathy in Patients With Chronic Kidney Disease Stage 5Xuan Li0Haoqi Sun1Zhaoguang Zhang2Jing Liu3Huiying Xu4Lin Ma5Haibo Zhang6Jialin Li7Qian Luo8Xiangming Wang9Min Guo10Zhentao Guo11Xuexun Chen12Department of Nephrology, Affiliated Hospital of Weifang Medical University, Weifang, ChinaDepartment of Nephrology, Affiliated Hospital of Weifang Medical University, Weifang, ChinaDepartment of Ultrasound, Affiliated Hospital of Weifang Medical University, Weifang, ChinaDepartment of Electrophysiology, Affiliated Hospital of Weifang Medical University, Weifang, ChinaDepartment of Nephrology, Affiliated Hospital of Weifang Medical University, Weifang, ChinaDepartment of Nephrology, Affiliated Hospital of Weifang Medical University, Weifang, ChinaDepartment of Nephrology, Affiliated Hospital of Weifang Medical University, Weifang, ChinaDepartment of Nephrology, Affiliated Hospital of Weifang Medical University, Weifang, ChinaDepartment of Ultrasound, Affiliated Hospital of Weifang Medical University, Weifang, ChinaDepartment of Nephrology, Affiliated Hospital of Weifang Medical University, Weifang, ChinaDepartment of Nephrology, Affiliated Hospital of Weifang Medical University, Weifang, ChinaDepartment of Nephrology, Affiliated Hospital of Weifang Medical University, Weifang, ChinaDepartment of Nephrology, Affiliated Hospital of Weifang Medical University, Weifang, ChinaObjectiveTo observe the feasibility of shear wave elastography (SWE) in the diagnosis of peripheral neuropathy in patients undergoing hemodialysis [chronic kidney disease stage 5 dialysis (CKD5D)].MethodsForty patients with CKD5D were divided into a uremic peripheral neuropathy (UPN) group (n = 25) and a non-UPN group (n = 15) according to the results of a neuro-electrophysiological examination. Sixteen healthy control subjects were also enrolled in this study. Two-dimensional ultrasound examination was conducted, and SWE was then performed to measure Young’s modulus of the tibial nerve. The left and right diameters (D1), anterior and posterior diameters (D2), perimeter (C), cross-sectional area (CSA), and Young’s modulus (E) were measured three times at the same non-entrapment site. The average values were recorded and calculated. The following evaluation indices were also analyzed: sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and area under the receiver operating characteristic curve (AUC).ResultsD1, D2, C, and CSA were not significantly different among the three groups (P > 0.05). However, the difference in the E value among the three groups was statistically significant (P < 0.05). The AUC was 0.889 based on the E value. Using a tibial nerve E value of 48.35 kPa as the cutoff value, the sensitivity, specificity, PPV, and NPV were 86.0%, 84.0%, 81.1%, and 88.1%, respectively.ConclusionsSWE is useful for the diagnosis of peripheral neuropathy in patients with CKD5D. Young’s modulus of 48.35 kPa for the tibial nerve is the optimal cutoff value and has the best diagnostic efficiency for peripheral neuropathy in CKD5D patients.https://www.frontiersin.org/articles/10.3389/fendo.2022.899822/fullchronic kidney diseaseperipheral neuropathycutoff valuetibial nerveelasticity imaging techniques |
| spellingShingle | Xuan Li Haoqi Sun Zhaoguang Zhang Jing Liu Huiying Xu Lin Ma Haibo Zhang Jialin Li Qian Luo Xiangming Wang Min Guo Zhentao Guo Xuexun Chen Shear Wave Elastography in the Diagnosis of Peripheral Neuropathy in Patients With Chronic Kidney Disease Stage 5 Frontiers in Endocrinology chronic kidney disease peripheral neuropathy cutoff value tibial nerve elasticity imaging techniques |
| title | Shear Wave Elastography in the Diagnosis of Peripheral Neuropathy in Patients With Chronic Kidney Disease Stage 5 |
| title_full | Shear Wave Elastography in the Diagnosis of Peripheral Neuropathy in Patients With Chronic Kidney Disease Stage 5 |
| title_fullStr | Shear Wave Elastography in the Diagnosis of Peripheral Neuropathy in Patients With Chronic Kidney Disease Stage 5 |
| title_full_unstemmed | Shear Wave Elastography in the Diagnosis of Peripheral Neuropathy in Patients With Chronic Kidney Disease Stage 5 |
| title_short | Shear Wave Elastography in the Diagnosis of Peripheral Neuropathy in Patients With Chronic Kidney Disease Stage 5 |
| title_sort | shear wave elastography in the diagnosis of peripheral neuropathy in patients with chronic kidney disease stage 5 |
| topic | chronic kidney disease peripheral neuropathy cutoff value tibial nerve elasticity imaging techniques |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.899822/full |
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