Pressure Overload Activates DNA-Damage Response in Cardiac Stromal Cells: A Novel Mechanism Behind Heart Failure With Preserved Ejection Fraction?

Pressure Overload Activates DNA-Damage Response in Cardiac Stromal Cells: A Novel Mechanism Behind Heart Failure With Preserved Ejection Fraction?

Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous syndrome characterized by impaired left ventricular (LV) diastolic function, with normal LV ejection fraction. Aortic valve stenosis can cause an HFpEF-like syndrome by inducing sustained pressure overload (PO) and cardiac rem...

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Bibliographic Details
Main Authors: Ilaria Stadiotti, Rosaria Santoro, Alessandro Scopece, Sergio Pirola, Anna Guarino, Gianluca Polvani, Angela Serena Maione, Flora Ascione, Qingsen Li, Domenico Delia, Marco Foiani, Giulio Pompilio, Elena Sommariva
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
heart failure
heart failure with preserved ejection fraction (HFpEF)
DNA damage response (DDR)
pressure overload
cardiac mesenchymal stromal cells
mechanical stretch effects
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2022.878268/full

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https://www.frontiersin.org/articles/10.3389/fcvm.2022.878268/full

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