Fibrinogen-to-albumin ratio is related to the severity of coronary artery disease in chronic kidney disease patients undergoing coronary angiography
Objectives: This study was to explore the potential relationship between the fibrinogen-to-albumin ratio (FAR) and the presence and severity of coronary artery disease (CAD) in stage 3–5 predialysis chronic kidney disease (CKD) patients. Design: This study included 978 patients undergoing coronary a...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-11-01
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| Series: | Nefrología (English Edition) |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2013251422001201 |
| _version_ | 1827979975461961728 |
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| author | Li-Hua Lin Hong Liu Dong-Hua Jin Jun Zou Yu-Xian Xie Hong Qiu Miao Jia Da-Mei Li Bi-Cheng Liu |
| author_facet | Li-Hua Lin Hong Liu Dong-Hua Jin Jun Zou Yu-Xian Xie Hong Qiu Miao Jia Da-Mei Li Bi-Cheng Liu |
| author_sort | Li-Hua Lin |
| collection | DOAJ |
| description | Objectives: This study was to explore the potential relationship between the fibrinogen-to-albumin ratio (FAR) and the presence and severity of coronary artery disease (CAD) in stage 3–5 predialysis chronic kidney disease (CKD) patients. Design: This study included 978 patients undergoing coronary angiography (CAG). CAD was defined as the presence of obstructive stenosis > 50% of the lumen diameter in any of the four main coronary arteries. Gensini scores (GSs), left main coronary artery (LMCA) and three-vessel coronary artery disease (TVD) were used to elevate the severity of CAD. Results: The adjusted odds ratios of CAD were 3.059 (95% CI: 1.859–5.032) and 2.670 (95% CI: 1.605–4.441) in the third and fourth quartiles of FAR compared with the first quartile, respectively. Among 759 patients diagnosed with CAD, multivariate logistic regression analysis showed that FAR (at the 0.01 level) was significantly positively associated with the presence of LMCA (adjusted OR = 1.177, 95% CI 1.067–1.299, P = 0.001) or TVD (adjusted OR = 1.154, 95% CI 1.076–1.238, P < 0.001), and a higher GS (adjusted OR = 1.152, 95% CI 1.073–1.238, P < 0.001). Conclusions: FAR levels were independently associated with the presence and severity of CAD in stage 3–5 predialysis CKD patients. Resumen: Objetivos: Este estudio pretendía explorar la relación potencial entre la relación fibrinógeno/albúmina (FAR) y la presencia y la gravedad de la enfermedad arterial coronaria (EAC) en pacientes con enfermedad renal crónica (ERC) en estadio 3-5 en la etapa prediálisis. Diseño: Este estudio incluyó a 978 pacientes tratados mediante angiografía coronaria. La EAC se definió como la presencia de estenosis obstructiva > 50% del diámetro de la luz de cualquiera de las 4 arterias coronarias principales. Se utilizaron las puntuaciones de Gensini (GS), la enfermedad de la arteria coronaria izquierda (EACI) y la EAC de 3 vasos (ETV) para evaluar la gravedad de la EAC. Resultados: Los cocientes de posibilidades de EAC fueron 3,059 (IC del 95%: 1,859-5,032) y 2,670 (IC del 95%: 1,605-4,441) en el tercer y el cuarto cuartiles de la FAR en comparación con el primer cuartil, respectivamente. Entre los 759 pacientes diagnosticados de EAC, el análisis de regresión logística de múltiples variables mostró que la FAR (al nivel 0,01) presentaba una asociación positiva significativa con la presencia de EACI (OR ajustada = 1,177, IC del 95%: 1,067-1,299, p = 0,001) o ETV (OR ajustada=1,154, IC del 95%: 1,076-1,238, p < 0,001) y una puntuación GS mayor (OR ajustada = 1,152, IC del 95%: 1,073-1,238, p < 0,001). Conclusiones: Los niveles de FAR se asociaron de manera independiente con la presencia y la gravedad de EAC en los pacientes con ERC en estadio 3-5 en la etapa prediálisis. |
| first_indexed | 2024-04-09T21:45:15Z |
| format | Article |
| id | doaj.art-1e3d9b8df10740dfa26e1a4b12bca9d0 |
| institution | Directory Open Access Journal |
| issn | 2013-2514 |
| language | English |
| last_indexed | 2024-04-09T21:45:15Z |
| publishDate | 2022-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Nefrología (English Edition) |
| spelling | doaj.art-1e3d9b8df10740dfa26e1a4b12bca9d02023-03-25T05:10:36ZengElsevierNefrología (English Edition)2013-25142022-11-01426696703Fibrinogen-to-albumin ratio is related to the severity of coronary artery disease in chronic kidney disease patients undergoing coronary angiographyLi-Hua Lin0Hong Liu1Dong-Hua Jin2Jun Zou3Yu-Xian Xie4Hong Qiu5Miao Jia6Da-Mei Li7Bi-Cheng Liu8Department of Nephrology, The People's Hospital of Suzhou New District, Suzhou, Jiangsu 215129, China; Department of Nephrology, Zhong Da Hospital Affiliated to Southeast University, Nanjing, Jiangsu 210009, ChinaDepartment of Nephrology, Zhong Da Hospital Affiliated to Southeast University, Nanjing, Jiangsu 210009, China; Corresponding authors.Department of Nephrology, The People's Hospital of Suzhou New District, Suzhou, Jiangsu 215129, China; Corresponding authors.Department of Nephrology, Xin Hua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200092, ChinaDepartment of Nephrology, The People's Hospital of Suzhou New District, Suzhou, Jiangsu 215129, ChinaDepartment of Nephrology, The People's Hospital of Suzhou New District, Suzhou, Jiangsu 215129, ChinaDepartment of Nephrology, The People's Hospital of Suzhou New District, Suzhou, Jiangsu 215129, ChinaDepartment of Nephrology, The People's Hospital of Suzhou New District, Suzhou, Jiangsu 215129, ChinaDepartment of Nephrology, Zhong Da Hospital Affiliated to Southeast University, Nanjing, Jiangsu 210009, ChinaObjectives: This study was to explore the potential relationship between the fibrinogen-to-albumin ratio (FAR) and the presence and severity of coronary artery disease (CAD) in stage 3–5 predialysis chronic kidney disease (CKD) patients. Design: This study included 978 patients undergoing coronary angiography (CAG). CAD was defined as the presence of obstructive stenosis > 50% of the lumen diameter in any of the four main coronary arteries. Gensini scores (GSs), left main coronary artery (LMCA) and three-vessel coronary artery disease (TVD) were used to elevate the severity of CAD. Results: The adjusted odds ratios of CAD were 3.059 (95% CI: 1.859–5.032) and 2.670 (95% CI: 1.605–4.441) in the third and fourth quartiles of FAR compared with the first quartile, respectively. Among 759 patients diagnosed with CAD, multivariate logistic regression analysis showed that FAR (at the 0.01 level) was significantly positively associated with the presence of LMCA (adjusted OR = 1.177, 95% CI 1.067–1.299, P = 0.001) or TVD (adjusted OR = 1.154, 95% CI 1.076–1.238, P < 0.001), and a higher GS (adjusted OR = 1.152, 95% CI 1.073–1.238, P < 0.001). Conclusions: FAR levels were independently associated with the presence and severity of CAD in stage 3–5 predialysis CKD patients. Resumen: Objetivos: Este estudio pretendía explorar la relación potencial entre la relación fibrinógeno/albúmina (FAR) y la presencia y la gravedad de la enfermedad arterial coronaria (EAC) en pacientes con enfermedad renal crónica (ERC) en estadio 3-5 en la etapa prediálisis. Diseño: Este estudio incluyó a 978 pacientes tratados mediante angiografía coronaria. La EAC se definió como la presencia de estenosis obstructiva > 50% del diámetro de la luz de cualquiera de las 4 arterias coronarias principales. Se utilizaron las puntuaciones de Gensini (GS), la enfermedad de la arteria coronaria izquierda (EACI) y la EAC de 3 vasos (ETV) para evaluar la gravedad de la EAC. Resultados: Los cocientes de posibilidades de EAC fueron 3,059 (IC del 95%: 1,859-5,032) y 2,670 (IC del 95%: 1,605-4,441) en el tercer y el cuarto cuartiles de la FAR en comparación con el primer cuartil, respectivamente. Entre los 759 pacientes diagnosticados de EAC, el análisis de regresión logística de múltiples variables mostró que la FAR (al nivel 0,01) presentaba una asociación positiva significativa con la presencia de EACI (OR ajustada = 1,177, IC del 95%: 1,067-1,299, p = 0,001) o ETV (OR ajustada=1,154, IC del 95%: 1,076-1,238, p < 0,001) y una puntuación GS mayor (OR ajustada = 1,152, IC del 95%: 1,073-1,238, p < 0,001). Conclusiones: Los niveles de FAR se asociaron de manera independiente con la presencia y la gravedad de EAC en los pacientes con ERC en estadio 3-5 en la etapa prediálisis.http://www.sciencedirect.com/science/article/pii/S2013251422001201Relación fibrinógeno/albúminaEnfermedad arterial coronariaEstenosis de la arteria coronariaEnfermedad renal crónicaAngiografía coronaria |
| spellingShingle | Li-Hua Lin Hong Liu Dong-Hua Jin Jun Zou Yu-Xian Xie Hong Qiu Miao Jia Da-Mei Li Bi-Cheng Liu Fibrinogen-to-albumin ratio is related to the severity of coronary artery disease in chronic kidney disease patients undergoing coronary angiography Nefrología (English Edition) Relación fibrinógeno/albúmina Enfermedad arterial coronaria Estenosis de la arteria coronaria Enfermedad renal crónica Angiografía coronaria |
| title | Fibrinogen-to-albumin ratio is related to the severity of coronary artery disease in chronic kidney disease patients undergoing coronary angiography |
| title_full | Fibrinogen-to-albumin ratio is related to the severity of coronary artery disease in chronic kidney disease patients undergoing coronary angiography |
| title_fullStr | Fibrinogen-to-albumin ratio is related to the severity of coronary artery disease in chronic kidney disease patients undergoing coronary angiography |
| title_full_unstemmed | Fibrinogen-to-albumin ratio is related to the severity of coronary artery disease in chronic kidney disease patients undergoing coronary angiography |
| title_short | Fibrinogen-to-albumin ratio is related to the severity of coronary artery disease in chronic kidney disease patients undergoing coronary angiography |
| title_sort | fibrinogen to albumin ratio is related to the severity of coronary artery disease in chronic kidney disease patients undergoing coronary angiography |
| topic | Relación fibrinógeno/albúmina Enfermedad arterial coronaria Estenosis de la arteria coronaria Enfermedad renal crónica Angiografía coronaria |
| url | http://www.sciencedirect.com/science/article/pii/S2013251422001201 |
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