Autologous versus prosthetic reconstruction for women with breast cancer who will undergo post-reconstruction radiotherapy

INTRODUCTION Radiotherapy is frequently used after breast reconstruction in patients with locally advanced breast cancer or metastases in axillary lymph nodes. However, there might be differences between autologous and prosthetic reconstruction in terms of effectiveness and safety of post-reconstru...

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Main Authors: Francisco Rubilar, Alfonso Navia, Bruno Dagnino
Format: Article
Language:English
Published: Medwave Estudios Limitada 2019-11-01
Series:Medwave
Subjects:
Online Access:https://www.medwave.cl/link.cgi/Medwave/PuestaDia/ResEpis/7728
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author Francisco Rubilar
Alfonso Navia
Bruno Dagnino
author_facet Francisco Rubilar
Alfonso Navia
Bruno Dagnino
author_sort Francisco Rubilar
collection DOAJ
description INTRODUCTION Radiotherapy is frequently used after breast reconstruction in patients with locally advanced breast cancer or metastases in axillary lymph nodes. However, there might be differences between autologous and prosthetic reconstruction in terms of effectiveness and safety of post-reconstruction radiotherapy. METHODS To answer this question we searched in Epistemonikos, the largest database of systematic reviews in health, which is maintained by screening multiple information sources, including MEDLINE, EMBASE, Cochrane, among others. We extracted data from the systematic reviews, reanalyzed data of primary studies, conducted a meta-analysis and generated a summary of findings table using the GRADE approach. RESULTS AND CONCLUSIONS We identified five systematic reviews including nine primary studies overall, of which all were observational studies. We concluded that in patients who will undergo post reconstructive radiotherapy, autologous breast reconstruction could reduce reoperations due to general complications compared to prosthetic breast reconstruction. However, it probably increases the risk of skin or flap necrosis. It is not clear whether there are differences in other outcomes as the certainty of evidence has been assessed as very low.
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spelling doaj.art-1e3e26131a85488eb77029ca194bbdd02022-12-22T00:03:29ZengMedwave Estudios LimitadaMedwave0717-63842019-11-011910e7727e772710.5867/medwave.2019.10.7727Autologous versus prosthetic reconstruction for women with breast cancer who will undergo post-reconstruction radiotherapyFrancisco Rubilar0Alfonso Navia1Bruno Dagnino2Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile; Proyecto Epistemonikos, Santiago, ChileProyecto Epistemonikos, Santiago, Chile; Sección de Cirugía Plástica y Reconstructiva, División de Cirugía, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, ChileProyecto Epistemonikos, Santiago, Chile; Sección de Cirugía Plástica y Reconstructiva, División de Cirugía, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, ChileINTRODUCTION Radiotherapy is frequently used after breast reconstruction in patients with locally advanced breast cancer or metastases in axillary lymph nodes. However, there might be differences between autologous and prosthetic reconstruction in terms of effectiveness and safety of post-reconstruction radiotherapy. METHODS To answer this question we searched in Epistemonikos, the largest database of systematic reviews in health, which is maintained by screening multiple information sources, including MEDLINE, EMBASE, Cochrane, among others. We extracted data from the systematic reviews, reanalyzed data of primary studies, conducted a meta-analysis and generated a summary of findings table using the GRADE approach. RESULTS AND CONCLUSIONS We identified five systematic reviews including nine primary studies overall, of which all were observational studies. We concluded that in patients who will undergo post reconstructive radiotherapy, autologous breast reconstruction could reduce reoperations due to general complications compared to prosthetic breast reconstruction. However, it probably increases the risk of skin or flap necrosis. It is not clear whether there are differences in other outcomes as the certainty of evidence has been assessed as very low.https://www.medwave.cl/link.cgi/Medwave/PuestaDia/ResEpis/7728post-mastectomy radiotherapyautologous breast reconstructionprosthetic breast reconstructionpostoperative morbidityepistemonikosgrade
spellingShingle Francisco Rubilar
Alfonso Navia
Bruno Dagnino
Autologous versus prosthetic reconstruction for women with breast cancer who will undergo post-reconstruction radiotherapy
Medwave
post-mastectomy radiotherapy
autologous breast reconstruction
prosthetic breast reconstruction
postoperative morbidity
epistemonikos
grade
title Autologous versus prosthetic reconstruction for women with breast cancer who will undergo post-reconstruction radiotherapy
title_full Autologous versus prosthetic reconstruction for women with breast cancer who will undergo post-reconstruction radiotherapy
title_fullStr Autologous versus prosthetic reconstruction for women with breast cancer who will undergo post-reconstruction radiotherapy
title_full_unstemmed Autologous versus prosthetic reconstruction for women with breast cancer who will undergo post-reconstruction radiotherapy
title_short Autologous versus prosthetic reconstruction for women with breast cancer who will undergo post-reconstruction radiotherapy
title_sort autologous versus prosthetic reconstruction for women with breast cancer who will undergo post reconstruction radiotherapy
topic post-mastectomy radiotherapy
autologous breast reconstruction
prosthetic breast reconstruction
postoperative morbidity
epistemonikos
grade
url https://www.medwave.cl/link.cgi/Medwave/PuestaDia/ResEpis/7728
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AT brunodagnino autologousversusprostheticreconstructionforwomenwithbreastcancerwhowillundergopostreconstructionradiotherapy