Analysis of the Oral Microbiome in a Patient with Cardiofaciocutaneous Syndrome and Severe Periodontal Disease: Impact of Systemic Antibiotic Therapy
An 8-year-old girl diagnosed with cardiofaciocutaneous syndrome presented to our department with gingival pain, inflammation, and bleeding. Her medical history included hypoplasia of the corpus callosum, intellectual disability, trichothiodystrophy, global developmental delay, myopia, laryngomalacia...
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MDPI AG
2022-12-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/11/12/1754 |
| _version_ | 1797461750008774656 |
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| author | Carolina Muñoz Navarro María del Carmen Sánchez Beltrán Carolina Arriagada Vargas Pilar Batalla Vázquez Márcio Diniz Freitas Jacobo Limeres Posse Pedro Diz Dios Eliane García Mato |
| author_facet | Carolina Muñoz Navarro María del Carmen Sánchez Beltrán Carolina Arriagada Vargas Pilar Batalla Vázquez Márcio Diniz Freitas Jacobo Limeres Posse Pedro Diz Dios Eliane García Mato |
| author_sort | Carolina Muñoz Navarro |
| collection | DOAJ |
| description | An 8-year-old girl diagnosed with cardiofaciocutaneous syndrome presented to our department with gingival pain, inflammation, and bleeding. Her medical history included hypoplasia of the corpus callosum, intellectual disability, trichothiodystrophy, global developmental delay, myopia, laryngomalacia, hypothyroidism, and osteoporosis. A diagnosis was reached of “periodontitis as a direct manifestation of systemic diseases”. During 9 years of follow-up, there were exacerbation episodes with spontaneous gum bleeding, ulcers in the interdental papilla, tooth mobility, and progressive tooth loss. Some of these exacerbation episodes resolved clinically with the administration of amoxicillin and metronidazole. We therefore proposed an oral microbiome study (subgingival and saliva samples) before and after antibiotic therapy. The most abundant genera at the subgingival level before administering antibiotics were <i>Prevotella</i>, <i>Streptococcus</i>, <i>Fusobacterium</i>, <i>Leptotrichia,</i> and <i>Aggregatibacter</i>. Of the 94 genera sequenced, 57 were less abundant in the post-treatment state than at baseline, particularly certain Gram-negative periodontal pathogens such as <i>Porphyromonas, Treponema, Aggregatibacter, Fusobacterium,</i> and <i>Campylobacter</i>. In contrast, other genera related to oral health, such as <i>Haemophilus, Granulicatella,</i> and <i>Abiotrophia</i>, showed an increase after administering the antibiotic. In conclusion, periodontitis exacerbations as a direct manifestation of systemic disease can occasionally be controlled exclusively with systemic antibiotics, without the need for performing mechanical periodontal therapy. This clinical recovery is correlated to substantial changes in the oral microbiome, which lead to the recovery of eubiosis of the microbiota. |
| first_indexed | 2024-03-09T17:23:45Z |
| format | Article |
| id | doaj.art-1e3e91b19a0e4f34bff177402686e144 |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-09T17:23:45Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-1e3e91b19a0e4f34bff177402686e1442023-11-24T12:53:49ZengMDPI AGAntibiotics2079-63822022-12-011112175410.3390/antibiotics11121754Analysis of the Oral Microbiome in a Patient with Cardiofaciocutaneous Syndrome and Severe Periodontal Disease: Impact of Systemic Antibiotic TherapyCarolina Muñoz Navarro0María del Carmen Sánchez Beltrán1Carolina Arriagada Vargas2Pilar Batalla Vázquez3Márcio Diniz Freitas4Jacobo Limeres Posse5Pedro Diz Dios6Eliane García Mato7Special Care Dentistry Postgraduate Training Program, School of Medicine and Dentistry, University of Santiago de Compostela (USC), 15782 A Coruña, SpainGINTRAMIS Research Group (Translational Research Group on Microbiota and Health), Department of Medicine, Faculty of Medicine, University Complutense, 28040 Madrid, SpainSpecial Care Dentistry Postgraduate Training Program, School of Medicine and Dentistry, University of Santiago de Compostela (USC), 15782 A Coruña, SpainMedical-Surgical Dentistry Research Group (OMEQUI), Health Research Institute of Santiago de Compostela (IDIS), University of Santiago de Compostela (USC), 15782 A Coruña, SpainMedical-Surgical Dentistry Research Group (OMEQUI), Health Research Institute of Santiago de Compostela (IDIS), University of Santiago de Compostela (USC), 15782 A Coruña, SpainMedical-Surgical Dentistry Research Group (OMEQUI), Health Research Institute of Santiago de Compostela (IDIS), University of Santiago de Compostela (USC), 15782 A Coruña, SpainMedical-Surgical Dentistry Research Group (OMEQUI), Health Research Institute of Santiago de Compostela (IDIS), University of Santiago de Compostela (USC), 15782 A Coruña, SpainMedical-Surgical Dentistry Research Group (OMEQUI), Health Research Institute of Santiago de Compostela (IDIS), University of Santiago de Compostela (USC), 15782 A Coruña, SpainAn 8-year-old girl diagnosed with cardiofaciocutaneous syndrome presented to our department with gingival pain, inflammation, and bleeding. Her medical history included hypoplasia of the corpus callosum, intellectual disability, trichothiodystrophy, global developmental delay, myopia, laryngomalacia, hypothyroidism, and osteoporosis. A diagnosis was reached of “periodontitis as a direct manifestation of systemic diseases”. During 9 years of follow-up, there were exacerbation episodes with spontaneous gum bleeding, ulcers in the interdental papilla, tooth mobility, and progressive tooth loss. Some of these exacerbation episodes resolved clinically with the administration of amoxicillin and metronidazole. We therefore proposed an oral microbiome study (subgingival and saliva samples) before and after antibiotic therapy. The most abundant genera at the subgingival level before administering antibiotics were <i>Prevotella</i>, <i>Streptococcus</i>, <i>Fusobacterium</i>, <i>Leptotrichia,</i> and <i>Aggregatibacter</i>. Of the 94 genera sequenced, 57 were less abundant in the post-treatment state than at baseline, particularly certain Gram-negative periodontal pathogens such as <i>Porphyromonas, Treponema, Aggregatibacter, Fusobacterium,</i> and <i>Campylobacter</i>. In contrast, other genera related to oral health, such as <i>Haemophilus, Granulicatella,</i> and <i>Abiotrophia</i>, showed an increase after administering the antibiotic. In conclusion, periodontitis exacerbations as a direct manifestation of systemic disease can occasionally be controlled exclusively with systemic antibiotics, without the need for performing mechanical periodontal therapy. This clinical recovery is correlated to substantial changes in the oral microbiome, which lead to the recovery of eubiosis of the microbiota.https://www.mdpi.com/2079-6382/11/12/1754cardiofaciocutaneous syndromeperiodontitisantibioticsmicrobiome |
| spellingShingle | Carolina Muñoz Navarro María del Carmen Sánchez Beltrán Carolina Arriagada Vargas Pilar Batalla Vázquez Márcio Diniz Freitas Jacobo Limeres Posse Pedro Diz Dios Eliane García Mato Analysis of the Oral Microbiome in a Patient with Cardiofaciocutaneous Syndrome and Severe Periodontal Disease: Impact of Systemic Antibiotic Therapy Antibiotics cardiofaciocutaneous syndrome periodontitis antibiotics microbiome |
| title | Analysis of the Oral Microbiome in a Patient with Cardiofaciocutaneous Syndrome and Severe Periodontal Disease: Impact of Systemic Antibiotic Therapy |
| title_full | Analysis of the Oral Microbiome in a Patient with Cardiofaciocutaneous Syndrome and Severe Periodontal Disease: Impact of Systemic Antibiotic Therapy |
| title_fullStr | Analysis of the Oral Microbiome in a Patient with Cardiofaciocutaneous Syndrome and Severe Periodontal Disease: Impact of Systemic Antibiotic Therapy |
| title_full_unstemmed | Analysis of the Oral Microbiome in a Patient with Cardiofaciocutaneous Syndrome and Severe Periodontal Disease: Impact of Systemic Antibiotic Therapy |
| title_short | Analysis of the Oral Microbiome in a Patient with Cardiofaciocutaneous Syndrome and Severe Periodontal Disease: Impact of Systemic Antibiotic Therapy |
| title_sort | analysis of the oral microbiome in a patient with cardiofaciocutaneous syndrome and severe periodontal disease impact of systemic antibiotic therapy |
| topic | cardiofaciocutaneous syndrome periodontitis antibiotics microbiome |
| url | https://www.mdpi.com/2079-6382/11/12/1754 |
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