Clinical Pharmacology and Pharmacokinetics of Levetiracetam
Status epilepticus and acute repetitive seizures still pose a management challenge despite the recent advances in the field of epilepsy. Parenteral formulations of old anticonvulsants are still a cornerstone in acute seizure management and are approved by the FDA. Intravenous levetiracetam, a second...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2013-12-01
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| Series: | Frontiers in Neurology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fneur.2013.00192/full |
| _version_ | 1819289937889984512 |
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| author | Chanin Clark Wright Jana eDowning Diana eMungall Owais eKhan Amanda eWilliams Ekokobe eFonkem Darin eGarrett Jose eAceves BATOOL F. KIRMANI |
| author_facet | Chanin Clark Wright Jana eDowning Diana eMungall Owais eKhan Amanda eWilliams Ekokobe eFonkem Darin eGarrett Jose eAceves BATOOL F. KIRMANI |
| author_sort | Chanin Clark Wright |
| collection | DOAJ |
| description | Status epilepticus and acute repetitive seizures still pose a management challenge despite the recent advances in the field of epilepsy. Parenteral formulations of old anticonvulsants are still a cornerstone in acute seizure management and are approved by the FDA. Intravenous levetiracetam, a second generation anticonvulsant, is approved by the FDA as an adjunctive treatment in patients 16 years or older when oral administration is not available. Data have shown that it has a unique mechanism of action, linear pharmacokinetics and no known drug interactions with other anticonvulsants. In this paper, we will review the current literature about the pharmacology and pharmacokinetics of intravenous levetiracetam and the safety profile of this new anticonvulsant in acute seizure management of both adults and children. |
| first_indexed | 2024-12-24T03:14:47Z |
| format | Article |
| id | doaj.art-1e405b9a862e46cbb2f21e0272768cd1 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-24T03:14:47Z |
| publishDate | 2013-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-1e405b9a862e46cbb2f21e0272768cd12022-12-21T17:17:39ZengFrontiers Media S.A.Frontiers in Neurology1664-22952013-12-01410.3389/fneur.2013.0019263190Clinical Pharmacology and Pharmacokinetics of LevetiracetamChanin Clark Wright0Jana eDowning1Diana eMungall2Owais eKhan3Amanda eWilliams4Ekokobe eFonkem5Darin eGarrett6Jose eAceves7BATOOL F. KIRMANI8TEXAS A& M HSC COLL OF MED/ SCOTT AND WHITE HEALTHCARETEXAS A& M HSC COLL OF MED/ SCOTT AND WHITE HEALTHCARETexas A&M Health Science Center College of MedicineUniversity of Chicago Medical CenterTEXAS A& M HSC COLL OF MED/ SCOTT AND WHITE HEALTHCAREScott & White Neuroscience InstituteTexas A&M UniversityTEXAS A& M HSC COLL OF MED/ SCOTT AND WHITE HEALTHCARETEXAS A& M HSC COLL OF MED/ SCOTT AND WHITE HEALTHCAREStatus epilepticus and acute repetitive seizures still pose a management challenge despite the recent advances in the field of epilepsy. Parenteral formulations of old anticonvulsants are still a cornerstone in acute seizure management and are approved by the FDA. Intravenous levetiracetam, a second generation anticonvulsant, is approved by the FDA as an adjunctive treatment in patients 16 years or older when oral administration is not available. Data have shown that it has a unique mechanism of action, linear pharmacokinetics and no known drug interactions with other anticonvulsants. In this paper, we will review the current literature about the pharmacology and pharmacokinetics of intravenous levetiracetam and the safety profile of this new anticonvulsant in acute seizure management of both adults and children.http://journal.frontiersin.org/Journal/10.3389/fneur.2013.00192/fullEpilepsySeizuresStatus Epilepticuspharmacokineticslevetiracetam |
| spellingShingle | Chanin Clark Wright Jana eDowning Diana eMungall Owais eKhan Amanda eWilliams Ekokobe eFonkem Darin eGarrett Jose eAceves BATOOL F. KIRMANI Clinical Pharmacology and Pharmacokinetics of Levetiracetam Frontiers in Neurology Epilepsy Seizures Status Epilepticus pharmacokinetics levetiracetam |
| title | Clinical Pharmacology and Pharmacokinetics of Levetiracetam |
| title_full | Clinical Pharmacology and Pharmacokinetics of Levetiracetam |
| title_fullStr | Clinical Pharmacology and Pharmacokinetics of Levetiracetam |
| title_full_unstemmed | Clinical Pharmacology and Pharmacokinetics of Levetiracetam |
| title_short | Clinical Pharmacology and Pharmacokinetics of Levetiracetam |
| title_sort | clinical pharmacology and pharmacokinetics of levetiracetam |
| topic | Epilepsy Seizures Status Epilepticus pharmacokinetics levetiracetam |
| url | http://journal.frontiersin.org/Journal/10.3389/fneur.2013.00192/full |
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