Silybin Modulates Collagen Turnover in an In Vitro Model of NASH

Silybin Modulates Collagen Turnover in an In Vitro Model of NASH

Silybin has been proposed as a treatment for nonalcoholic steatohepatitis (NASH). In this study, we assessed the effect of Silybin in a well-established in vitro coculture model of early-stage NASH. LX2 and Huh7 cells were exposed to free fatty acid (FFA) and Silybin as mono- or coculture (SCC). Cel...

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Bibliographic Details
Main Authors: Beatrice Anfuso, Pablo J. Giraudi, Claudio Tiribelli, Natalia Rosso
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:Molecules
Subjects:
NAFLD
NASH
Silybin
fibrogenesis
coculture model
hepatic stellate cells
Online Access:https://www.mdpi.com/1420-3049/24/7/1280

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