Untargeted Metabolome Analysis Reveals Reductions in Maternal Hepatic Glucose and Amino Acid Content That Correlate with Fetal Organ Weights in a Mouse Model of Fetal Alcohol Spectrum Disorders

Untargeted Metabolome Analysis Reveals Reductions in Maternal Hepatic Glucose and Amino Acid Content That Correlate with Fetal Organ Weights in a Mouse Model of Fetal Alcohol Spectrum Disorders

Prenatal alcohol exposure (PAE) causes fetal growth restrictions. A major driver of fetal growth deficits is maternal metabolic disruption; this is under-investigated following PAE. Untargeted metabolomics on the dam and fetus exposed to alcohol (ALC) revealed that the hepatic metabolome of ALC and...

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Bibliographic Details
Main Authors: Nipun Saini, Manjot S. Virdee, Kaylee K. Helfrich, Sze Ting Cecilia Kwan, Sandra M. Mooney, Susan M. Smith
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Nutrients
Subjects:
pregnancy
prenatal alcohol exposure
hepatic metabolism
untargeted metabolomics
glucose
amino acids
Online Access:https://www.mdpi.com/2072-6643/14/5/1096

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