Advanced Glycation End Products (AGE) and Soluble Forms of AGE Receptor: Emerging Role as Mortality Risk Factors in CKD
Advanced glycation end-products (AGE) can promote chronic kidney disease (CKD) progression and CKD-related morbidities. The soluble receptor for AGE (sRAGE) is a potential biomarker of inflammation and oxidative stress. Here, we explored the role of AGE, glycated albumin, sRAGE and its different for...
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| Format: | Article |
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MDPI AG
2020-12-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/8/12/638 |
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| author | Elena Dozio Simone Vettoretti Lara Caldiroli Silvia Nerini-Molteni Lorenza Tacchini Federico Ambrogi Piergiorgio Messa Massimiliano M. Corsi Romanelli |
| author_facet | Elena Dozio Simone Vettoretti Lara Caldiroli Silvia Nerini-Molteni Lorenza Tacchini Federico Ambrogi Piergiorgio Messa Massimiliano M. Corsi Romanelli |
| author_sort | Elena Dozio |
| collection | DOAJ |
| description | Advanced glycation end-products (AGE) can promote chronic kidney disease (CKD) progression and CKD-related morbidities. The soluble receptor for AGE (sRAGE) is a potential biomarker of inflammation and oxidative stress. Here, we explored the role of AGE, glycated albumin, sRAGE and its different forms, cRAGE and esRAGE, as prognostic factors for mortality in 111 advanced CKD patients. The median follow-up time was 39 months. AGE were quantified by fluorescence, sRAGE and its forms by ELISA. Malnutrition was screened by the Malnutrition Inflammation Score (MIS). The Cox proportional hazards regression model was used to assess the association of variables with all-cause mortality. Mean levels of sRAGE, esRAGE and cRAGE were 2318 ± 1224, 649 ± 454 and 1669 ± 901 pg/mL. The mean value of cRAGE/esRAGE was 2.82 ± 0.96. AGE were 3026 ± 766 AU and MIS 6.0 ± 4.7. eGFR correlated negatively with AGE, sRAGE, esRAGE and cRAGE, but not with cRAGE/esRAGE. Twenty-eight patients died. No difference was observed between diabetic and non-diabetic patients. Starting dialysis was not associated with enhanced risk of death. AGE, esRAGE and cRAGE/esRAGE were independently associated with all-cause mortality. AGE, esRAGE and cRAGE/esRAGE may help to stratify overall mortality risk. Implementing the clinical evaluation of CKD patients by quantifying these biomarkers can help to improve patient outcomes. |
| first_indexed | 2024-03-10T13:52:55Z |
| format | Article |
| id | doaj.art-1e41598173cf4f4a8b6afc5a3df2fa4a |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T13:52:55Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-1e41598173cf4f4a8b6afc5a3df2fa4a2023-11-21T01:54:38ZengMDPI AGBiomedicines2227-90592020-12-0181263810.3390/biomedicines8120638Advanced Glycation End Products (AGE) and Soluble Forms of AGE Receptor: Emerging Role as Mortality Risk Factors in CKDElena Dozio0Simone Vettoretti1Lara Caldiroli2Silvia Nerini-Molteni3Lorenza Tacchini4Federico Ambrogi5Piergiorgio Messa6Massimiliano M. Corsi Romanelli7Department of Biomedical Science for Health, Laboratory of Clinical Pathology, Università degli Studi di Milano, 20133 Milan, ItalyUnit of Nephrology, Dialysis and Kidney Transplantation, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico di Milano, 20122 Milan, ItalyUnit of Nephrology, Dialysis and Kidney Transplantation, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico di Milano, 20122 Milan, ItalyDepartment of Clinical Microbiology, ASST Grande Ospedale Metropolitano Niguarda, 20162 Milan, ItalyDepartment of Biomedical Science for Health, Laboratory of Clinical Pathology, Università degli Studi di Milano, 20133 Milan, ItalyDepartment of Clinical Science and Community Health, Laboratory of Medical Statistics and Biometry “Giulio A. Maccacaro” Università degli Studi di Milano, 20133 Milan, ItalyUnit of Nephrology, Dialysis and Kidney Transplantation, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico di Milano, 20122 Milan, ItalyDepartment of Biomedical Science for Health, Laboratory of Clinical Pathology, Università degli Studi di Milano, 20133 Milan, ItalyAdvanced glycation end-products (AGE) can promote chronic kidney disease (CKD) progression and CKD-related morbidities. The soluble receptor for AGE (sRAGE) is a potential biomarker of inflammation and oxidative stress. Here, we explored the role of AGE, glycated albumin, sRAGE and its different forms, cRAGE and esRAGE, as prognostic factors for mortality in 111 advanced CKD patients. The median follow-up time was 39 months. AGE were quantified by fluorescence, sRAGE and its forms by ELISA. Malnutrition was screened by the Malnutrition Inflammation Score (MIS). The Cox proportional hazards regression model was used to assess the association of variables with all-cause mortality. Mean levels of sRAGE, esRAGE and cRAGE were 2318 ± 1224, 649 ± 454 and 1669 ± 901 pg/mL. The mean value of cRAGE/esRAGE was 2.82 ± 0.96. AGE were 3026 ± 766 AU and MIS 6.0 ± 4.7. eGFR correlated negatively with AGE, sRAGE, esRAGE and cRAGE, but not with cRAGE/esRAGE. Twenty-eight patients died. No difference was observed between diabetic and non-diabetic patients. Starting dialysis was not associated with enhanced risk of death. AGE, esRAGE and cRAGE/esRAGE were independently associated with all-cause mortality. AGE, esRAGE and cRAGE/esRAGE may help to stratify overall mortality risk. Implementing the clinical evaluation of CKD patients by quantifying these biomarkers can help to improve patient outcomes.https://www.mdpi.com/2227-9059/8/12/638advanced glycation end-products (AGE)chronic kidney disease (CKD)mortalitysoluble receptor for AGE (sRAGE) |
| spellingShingle | Elena Dozio Simone Vettoretti Lara Caldiroli Silvia Nerini-Molteni Lorenza Tacchini Federico Ambrogi Piergiorgio Messa Massimiliano M. Corsi Romanelli Advanced Glycation End Products (AGE) and Soluble Forms of AGE Receptor: Emerging Role as Mortality Risk Factors in CKD Biomedicines advanced glycation end-products (AGE) chronic kidney disease (CKD) mortality soluble receptor for AGE (sRAGE) |
| title | Advanced Glycation End Products (AGE) and Soluble Forms of AGE Receptor: Emerging Role as Mortality Risk Factors in CKD |
| title_full | Advanced Glycation End Products (AGE) and Soluble Forms of AGE Receptor: Emerging Role as Mortality Risk Factors in CKD |
| title_fullStr | Advanced Glycation End Products (AGE) and Soluble Forms of AGE Receptor: Emerging Role as Mortality Risk Factors in CKD |
| title_full_unstemmed | Advanced Glycation End Products (AGE) and Soluble Forms of AGE Receptor: Emerging Role as Mortality Risk Factors in CKD |
| title_short | Advanced Glycation End Products (AGE) and Soluble Forms of AGE Receptor: Emerging Role as Mortality Risk Factors in CKD |
| title_sort | advanced glycation end products age and soluble forms of age receptor emerging role as mortality risk factors in ckd |
| topic | advanced glycation end-products (AGE) chronic kidney disease (CKD) mortality soluble receptor for AGE (sRAGE) |
| url | https://www.mdpi.com/2227-9059/8/12/638 |
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