Repurposing Cannabidiol as a Potential Drug Candidate for Anti-Tumor Therapies
In recent years, evidence has accumulated that cannabinoids—especially the non-psychoactive compound, cannabidiol (CBD)—possess promising medical and pharmacological activities that might qualify them as potential anti-tumor drugs. This review is based on multiple studies summarizing different mecha...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | Biomolecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-273X/11/4/582 |
| _version_ | 1797537569097908224 |
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| author | Fei Wang Gabriele Multhoff |
| author_facet | Fei Wang Gabriele Multhoff |
| author_sort | Fei Wang |
| collection | DOAJ |
| description | In recent years, evidence has accumulated that cannabinoids—especially the non-psychoactive compound, cannabidiol (CBD)—possess promising medical and pharmacological activities that might qualify them as potential anti-tumor drugs. This review is based on multiple studies summarizing different mechanisms for how CBD can target tumor cells including cannabinoid receptors or other constituents of the endocannabinoid system, and their complex activation of biological systems that results in the inhibition of tumor growth. CBD also participates in anti-inflammatory activities which are related to tumor progression, as demonstrated in preclinical models. Although the numbers of clinical trials and tested tumor entities are limited, there is clear evidence that CBD has anti-tumor efficacy and is well tolerated in human cancer patients. In summary, it appears that CBD has potential as a neoadjuvant and/or adjuvant drug in therapy for cancer. |
| first_indexed | 2024-03-10T12:17:03Z |
| format | Article |
| id | doaj.art-1e415c3f55c64727bd8be3ee628c623b |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-10T12:17:03Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-1e415c3f55c64727bd8be3ee628c623b2023-11-21T15:43:48ZengMDPI AGBiomolecules2218-273X2021-04-0111458210.3390/biom11040582Repurposing Cannabidiol as a Potential Drug Candidate for Anti-Tumor TherapiesFei Wang0Gabriele Multhoff1Radiation-Immuno Oncology Group, TranslaTUM—Central Institute for Translational Cancer Research, Klinikum rechts der Isar, TU München, Einsteinstr. 25, 81675 Munich, GermanyRadiation-Immuno Oncology Group, TranslaTUM—Central Institute for Translational Cancer Research, Klinikum rechts der Isar, TU München, Einsteinstr. 25, 81675 Munich, GermanyIn recent years, evidence has accumulated that cannabinoids—especially the non-psychoactive compound, cannabidiol (CBD)—possess promising medical and pharmacological activities that might qualify them as potential anti-tumor drugs. This review is based on multiple studies summarizing different mechanisms for how CBD can target tumor cells including cannabinoid receptors or other constituents of the endocannabinoid system, and their complex activation of biological systems that results in the inhibition of tumor growth. CBD also participates in anti-inflammatory activities which are related to tumor progression, as demonstrated in preclinical models. Although the numbers of clinical trials and tested tumor entities are limited, there is clear evidence that CBD has anti-tumor efficacy and is well tolerated in human cancer patients. In summary, it appears that CBD has potential as a neoadjuvant and/or adjuvant drug in therapy for cancer.https://www.mdpi.com/2218-273X/11/4/582cannabinoidscannabidiolanti-tumor therapy |
| spellingShingle | Fei Wang Gabriele Multhoff Repurposing Cannabidiol as a Potential Drug Candidate for Anti-Tumor Therapies Biomolecules cannabinoids cannabidiol anti-tumor therapy |
| title | Repurposing Cannabidiol as a Potential Drug Candidate for Anti-Tumor Therapies |
| title_full | Repurposing Cannabidiol as a Potential Drug Candidate for Anti-Tumor Therapies |
| title_fullStr | Repurposing Cannabidiol as a Potential Drug Candidate for Anti-Tumor Therapies |
| title_full_unstemmed | Repurposing Cannabidiol as a Potential Drug Candidate for Anti-Tumor Therapies |
| title_short | Repurposing Cannabidiol as a Potential Drug Candidate for Anti-Tumor Therapies |
| title_sort | repurposing cannabidiol as a potential drug candidate for anti tumor therapies |
| topic | cannabinoids cannabidiol anti-tumor therapy |
| url | https://www.mdpi.com/2218-273X/11/4/582 |
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