Recent Advances in Organelle-Targeted Fluorescent Probes
Recent advances in fluorescence imaging techniques and super-resolution microscopy have extended the applications of fluorescent probes in studying various cellular processes at the molecular level. Specifically, organelle-targeted probes have been commonly used to detect cellular metabolites and tr...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-01-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/26/1/217 |
| _version_ | 1797542448622206976 |
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| author | Na-Eun Choi Ji-Yu Lee Eun-Chae Park Ju-Hee Lee Jiyoun Lee |
| author_facet | Na-Eun Choi Ji-Yu Lee Eun-Chae Park Ju-Hee Lee Jiyoun Lee |
| author_sort | Na-Eun Choi |
| collection | DOAJ |
| description | Recent advances in fluorescence imaging techniques and super-resolution microscopy have extended the applications of fluorescent probes in studying various cellular processes at the molecular level. Specifically, organelle-targeted probes have been commonly used to detect cellular metabolites and transient chemical messengers with high precision and have become invaluable tools to study biochemical pathways. Moreover, several recent studies reported various labeling strategies and novel chemical scaffolds to enhance target specificity and responsiveness. In this review, we will survey the most recent reports of organelle-targeted fluorescent probes and assess their general strategies and structural features on the basis of their target organelles. We will discuss the advantages of the currently used probes and the potential challenges in their application as well as future directions. |
| first_indexed | 2024-03-10T13:30:41Z |
| format | Article |
| id | doaj.art-1e45e178352847d7a3ad5c2e8dc50242 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T13:30:41Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-1e45e178352847d7a3ad5c2e8dc502422023-11-21T08:02:53ZengMDPI AGMolecules1420-30492021-01-0126121710.3390/molecules26010217Recent Advances in Organelle-Targeted Fluorescent ProbesNa-Eun Choi0Ji-Yu Lee1Eun-Chae Park2Ju-Hee Lee3Jiyoun Lee4Department of Next-Generation Applied Science, and Global Medical Science, Sungshin University, Seoul 01133, KoreaDepartment of Next-Generation Applied Science, and Global Medical Science, Sungshin University, Seoul 01133, KoreaDepartment of Next-Generation Applied Science, and Global Medical Science, Sungshin University, Seoul 01133, KoreaDepartment of Next-Generation Applied Science, and Global Medical Science, Sungshin University, Seoul 01133, KoreaDepartment of Next-Generation Applied Science, and Global Medical Science, Sungshin University, Seoul 01133, KoreaRecent advances in fluorescence imaging techniques and super-resolution microscopy have extended the applications of fluorescent probes in studying various cellular processes at the molecular level. Specifically, organelle-targeted probes have been commonly used to detect cellular metabolites and transient chemical messengers with high precision and have become invaluable tools to study biochemical pathways. Moreover, several recent studies reported various labeling strategies and novel chemical scaffolds to enhance target specificity and responsiveness. In this review, we will survey the most recent reports of organelle-targeted fluorescent probes and assess their general strategies and structural features on the basis of their target organelles. We will discuss the advantages of the currently used probes and the potential challenges in their application as well as future directions.https://www.mdpi.com/1420-3049/26/1/217fluorescence imagingorganelle-targetingchemical probes |
| spellingShingle | Na-Eun Choi Ji-Yu Lee Eun-Chae Park Ju-Hee Lee Jiyoun Lee Recent Advances in Organelle-Targeted Fluorescent Probes Molecules fluorescence imaging organelle-targeting chemical probes |
| title | Recent Advances in Organelle-Targeted Fluorescent Probes |
| title_full | Recent Advances in Organelle-Targeted Fluorescent Probes |
| title_fullStr | Recent Advances in Organelle-Targeted Fluorescent Probes |
| title_full_unstemmed | Recent Advances in Organelle-Targeted Fluorescent Probes |
| title_short | Recent Advances in Organelle-Targeted Fluorescent Probes |
| title_sort | recent advances in organelle targeted fluorescent probes |
| topic | fluorescence imaging organelle-targeting chemical probes |
| url | https://www.mdpi.com/1420-3049/26/1/217 |
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