The changing epidemiology of hepatitis B and C infections in Nanoro, rural Burkina Faso: a random sampling survey
Abstract Background This study sought to provide up-to-date hepatitis B (HBV) and C (HCV) seroprevalence in rural Burkina Faso decade after hepatitis B vaccine was introduced in the national immunization scheduled for children. Methods In 2018, a community-based, random sampling strategy with probab...
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| Format: | Article |
| Language: | English |
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BMC
2020-01-01
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| Series: | BMC Infectious Diseases |
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| Online Access: | https://doi.org/10.1186/s12879-019-4731-7 |
| _version_ | 1818392815438135296 |
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| author | Moussa Lingani Tomoyuki Akita Serge Ouoba Shintaro Nagashima Palwende Romuald Boua Kazuaki Takahashi Basile Kam Aya Sugiyama Théodore Nikiema Chikako Yamamoto Athanase Somé Karim Derra Ko Ko Hermann Sorgho Zekiba Tarnagda Halidou Tinto Junko Tanaka |
| author_facet | Moussa Lingani Tomoyuki Akita Serge Ouoba Shintaro Nagashima Palwende Romuald Boua Kazuaki Takahashi Basile Kam Aya Sugiyama Théodore Nikiema Chikako Yamamoto Athanase Somé Karim Derra Ko Ko Hermann Sorgho Zekiba Tarnagda Halidou Tinto Junko Tanaka |
| author_sort | Moussa Lingani |
| collection | DOAJ |
| description | Abstract Background This study sought to provide up-to-date hepatitis B (HBV) and C (HCV) seroprevalence in rural Burkina Faso decade after hepatitis B vaccine was introduced in the national immunization scheduled for children. Methods In 2018, a community-based, random sampling strategy with probability proportional to population size was conducted in Nanoro to investigate the prevalence of viral hepatitis in children and their mothers. Sociodemographic, vaccination history and risk factors were assessed by interview and health books. HBsAg rapid tests were done by finger prick and Dried Blood Spots (DBS) were collected for hepatitis seromarkers by chemiluminescence enzyme immunoassay. Positive samples underwent confirmatory PCR and phylogenetic analysis. Results Data were presented on 240 mother-child pairs. HBsAg Prevalence was 0.8% in children and 6.3% in mothers. Hepatitis B core antibody positivity was 89.2% in mothers, 59.2% in children and was associated with age, sex and scarification. Hepatitis B surface antibodies prevalence was 37.5% in children and 5.8% in mothers. Good vaccination coverage was limited by home delivery. Phylogenetic analysis of HBV strains based on full genome sequences (n = 7) and s-fragment sequences (n = 6) revealed genotype A, E, and recombinant A3/E. Viral genome homology was reported in one mother-child pair. Anti-HCV prevalence was 5.4% in mothers, 2.1% in children and strains belonged to genotype 2. Conclusions In Nanoro, HBsAg prevalence was low in children, intermediate in mothers and mother-to-child transmission persists. Home delivery was a limiting factor of Hepatitis B vaccination coverage. HBV genotype E was predominant and genotype A3/E is reported for the first time in Burkina Faso. |
| first_indexed | 2024-12-14T05:35:25Z |
| format | Article |
| id | doaj.art-1e4616672d624658ac91e7207aab0c14 |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-12-14T05:35:25Z |
| publishDate | 2020-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-1e4616672d624658ac91e7207aab0c142022-12-21T23:15:10ZengBMCBMC Infectious Diseases1471-23342020-01-0120111410.1186/s12879-019-4731-7The changing epidemiology of hepatitis B and C infections in Nanoro, rural Burkina Faso: a random sampling surveyMoussa Lingani0Tomoyuki Akita1Serge Ouoba2Shintaro Nagashima3Palwende Romuald Boua4Kazuaki Takahashi5Basile Kam6Aya Sugiyama7Théodore Nikiema8Chikako Yamamoto9Athanase Somé10Karim Derra11Ko Ko12Hermann Sorgho13Zekiba Tarnagda14Halidou Tinto15Junko Tanaka16Department of Epidemiology, Infectious Disease Control and Prevention, Hiroshima University Graduate School of Biomedical and Health SciencesDepartment of Epidemiology, Infectious Disease Control and Prevention, Hiroshima University Graduate School of Biomedical and Health SciencesUnité de Recherche Clinique de Nanoro (URCN)Department of Epidemiology, Infectious Disease Control and Prevention, Hiroshima University Graduate School of Biomedical and Health SciencesUnité de Recherche Clinique de Nanoro (URCN)Department of Epidemiology, Infectious Disease Control and Prevention, Hiroshima University Graduate School of Biomedical and Health SciencesUnité de Recherche Clinique de Nanoro (URCN)Department of Epidemiology, Infectious Disease Control and Prevention, Hiroshima University Graduate School of Biomedical and Health SciencesUnité de Recherche Clinique de Nanoro (URCN)Department of Epidemiology, Infectious Disease Control and Prevention, Hiroshima University Graduate School of Biomedical and Health SciencesUnité de Recherche Clinique de Nanoro (URCN)Institut de Recherche en Sciences de la Santé, Direction Régionale du Centre Ouest (IRSS/DRCO)Department of Epidemiology, Infectious Disease Control and Prevention, Hiroshima University Graduate School of Biomedical and Health SciencesInstitut de Recherche en Sciences de la Santé, Direction Régionale du Centre Ouest (IRSS/DRCO)Institut de Recherche en Sciences de la SantéInstitut de Recherche en Sciences de la Santé, Direction Régionale du Centre Ouest (IRSS/DRCO)Department of Epidemiology, Infectious Disease Control and Prevention, Hiroshima University Graduate School of Biomedical and Health SciencesAbstract Background This study sought to provide up-to-date hepatitis B (HBV) and C (HCV) seroprevalence in rural Burkina Faso decade after hepatitis B vaccine was introduced in the national immunization scheduled for children. Methods In 2018, a community-based, random sampling strategy with probability proportional to population size was conducted in Nanoro to investigate the prevalence of viral hepatitis in children and their mothers. Sociodemographic, vaccination history and risk factors were assessed by interview and health books. HBsAg rapid tests were done by finger prick and Dried Blood Spots (DBS) were collected for hepatitis seromarkers by chemiluminescence enzyme immunoassay. Positive samples underwent confirmatory PCR and phylogenetic analysis. Results Data were presented on 240 mother-child pairs. HBsAg Prevalence was 0.8% in children and 6.3% in mothers. Hepatitis B core antibody positivity was 89.2% in mothers, 59.2% in children and was associated with age, sex and scarification. Hepatitis B surface antibodies prevalence was 37.5% in children and 5.8% in mothers. Good vaccination coverage was limited by home delivery. Phylogenetic analysis of HBV strains based on full genome sequences (n = 7) and s-fragment sequences (n = 6) revealed genotype A, E, and recombinant A3/E. Viral genome homology was reported in one mother-child pair. Anti-HCV prevalence was 5.4% in mothers, 2.1% in children and strains belonged to genotype 2. Conclusions In Nanoro, HBsAg prevalence was low in children, intermediate in mothers and mother-to-child transmission persists. Home delivery was a limiting factor of Hepatitis B vaccination coverage. HBV genotype E was predominant and genotype A3/E is reported for the first time in Burkina Faso.https://doi.org/10.1186/s12879-019-4731-7Burkina FasoHepatitis B virusHepatitis C virusGenotypeVaccination |
| spellingShingle | Moussa Lingani Tomoyuki Akita Serge Ouoba Shintaro Nagashima Palwende Romuald Boua Kazuaki Takahashi Basile Kam Aya Sugiyama Théodore Nikiema Chikako Yamamoto Athanase Somé Karim Derra Ko Ko Hermann Sorgho Zekiba Tarnagda Halidou Tinto Junko Tanaka The changing epidemiology of hepatitis B and C infections in Nanoro, rural Burkina Faso: a random sampling survey BMC Infectious Diseases Burkina Faso Hepatitis B virus Hepatitis C virus Genotype Vaccination |
| title | The changing epidemiology of hepatitis B and C infections in Nanoro, rural Burkina Faso: a random sampling survey |
| title_full | The changing epidemiology of hepatitis B and C infections in Nanoro, rural Burkina Faso: a random sampling survey |
| title_fullStr | The changing epidemiology of hepatitis B and C infections in Nanoro, rural Burkina Faso: a random sampling survey |
| title_full_unstemmed | The changing epidemiology of hepatitis B and C infections in Nanoro, rural Burkina Faso: a random sampling survey |
| title_short | The changing epidemiology of hepatitis B and C infections in Nanoro, rural Burkina Faso: a random sampling survey |
| title_sort | changing epidemiology of hepatitis b and c infections in nanoro rural burkina faso a random sampling survey |
| topic | Burkina Faso Hepatitis B virus Hepatitis C virus Genotype Vaccination |
| url | https://doi.org/10.1186/s12879-019-4731-7 |
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