Degenerate CD8 Epitopes Mapping to Structurally Constrained Regions of the Spike Protein: A T Cell-Based Way-Out From the SARS-CoV-2 Variants Storm

Degenerate CD8 Epitopes Mapping to Structurally Constrained Regions of the Spike Protein: A T Cell-Based Way-Out From the SARS-CoV-2 Variants Storm

There is an urgent need for new generation anti-SARS-Cov-2 vaccines in order to increase the efficacy of immunization and its broadness of protection against viral variants that are continuously arising and spreading. The effect of variants on protective immunity afforded by vaccination has been mos...

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Bibliographic Details
Main Authors:	Carolina Boni, Davide Cavazzini, Angelo Bolchi, Marzia Rossi, Andrea Vecchi, Camilla Tiezzi, Valeria Barili, Paola Fisicaro, Carlo Ferrari, Simone Ottonello
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-09-01
Series:	Frontiers in Immunology
Subjects:	SARS-Cov-2 CD8 T cells CD8 T cell epitopes neutralizing antibodies SARS-Cov-2 variants spike region
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2021.730051/full

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