The Implication of Androgens in the Presence of Protein Kinase C to Repair Alzheimer’s Disease-Induced Cognitive Dysfunction
Aging, as a major risk factor of memory deficiency, affects neural signaling pathways in hippocampus. In particular, age-dependent androgens deficiency causes cognitive impairments. Several enzymes like protein kinase C (PKC) are involved in memory deficiency. Indeed, PKC regulatory process mediates...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Pasteur Institute of Iran
2020-03-01
|
| Series: | Iranian Biomedical Journal |
| Subjects: | |
| Online Access: | http://ibj.pasteur.ac.ir/article-1-2951-en.html |
| _version_ | 1818516157102030848 |
|---|---|
| author | Sara Amiri Kayhan Azadmanesh Marzieh Dehghan Shasaltaneh Vafa Mayahi Nasser Naghdi |
| author_facet | Sara Amiri Kayhan Azadmanesh Marzieh Dehghan Shasaltaneh Vafa Mayahi Nasser Naghdi |
| author_sort | Sara Amiri |
| collection | DOAJ |
| description | Aging, as a major risk factor of memory deficiency, affects neural signaling pathways in hippocampus. In particular, age-dependent androgens deficiency causes cognitive impairments. Several enzymes like protein kinase C (PKC) are involved in memory deficiency. Indeed, PKC regulatory process mediates α-secretase activation to cleave APP in β-amyloid cascade and tau proteins phosphorylation mechanism. Androgens and cortisol regulate PKC signaling pathways, affecting the modulation of receptor for activated C kinase 1. Mitogen-activated protein kinase/ERK signaling pathway depends on CREB activity in hippocampal neurons and is involved in regulatory processes via PKC and androgens. Therefore, testosterone and PKC contribute in the neuronal apoptosis. The present review summarizes the current status of androgens, PKC, and their influence on cognitive learning. Inconsistencies in experimental investigations related to this fundamental correlation are also discussed, with emphasis on the mentioned contributors as the probable potent candidates for learning and memory improvement. |
| first_indexed | 2024-12-11T00:38:22Z |
| format | Article |
| id | doaj.art-1e47b36b42b544038f81ba54b78e8481 |
| institution | Directory Open Access Journal |
| issn | 1028-852X 2008-823X |
| language | English |
| last_indexed | 2024-12-11T00:38:22Z |
| publishDate | 2020-03-01 |
| publisher | Pasteur Institute of Iran |
| record_format | Article |
| series | Iranian Biomedical Journal |
| spelling | doaj.art-1e47b36b42b544038f81ba54b78e84812022-12-22T01:27:01ZengPasteur Institute of IranIranian Biomedical Journal1028-852X2008-823X2020-03-012426480The Implication of Androgens in the Presence of Protein Kinase C to Repair Alzheimer’s Disease-Induced Cognitive DysfunctionSara Amiri0Kayhan Azadmanesh1Marzieh Dehghan Shasaltaneh2Vafa Mayahi3Nasser Naghdi4 Department of Physiology and Pharmacology, Pasteur Institute of Iran, Tehran, Iran Department of Virology, Pasteur Institute of Iran, Tehran, Iran Department of Biology, Faculty of Science, University of Zanjan, Zanjan, Iran Department of Microbiology, Islamic Azad University, Karaj, Iran Department of Physiology and Pharmacology, Pasteur Institute of Iran, Tehran, Iran Aging, as a major risk factor of memory deficiency, affects neural signaling pathways in hippocampus. In particular, age-dependent androgens deficiency causes cognitive impairments. Several enzymes like protein kinase C (PKC) are involved in memory deficiency. Indeed, PKC regulatory process mediates α-secretase activation to cleave APP in β-amyloid cascade and tau proteins phosphorylation mechanism. Androgens and cortisol regulate PKC signaling pathways, affecting the modulation of receptor for activated C kinase 1. Mitogen-activated protein kinase/ERK signaling pathway depends on CREB activity in hippocampal neurons and is involved in regulatory processes via PKC and androgens. Therefore, testosterone and PKC contribute in the neuronal apoptosis. The present review summarizes the current status of androgens, PKC, and their influence on cognitive learning. Inconsistencies in experimental investigations related to this fundamental correlation are also discussed, with emphasis on the mentioned contributors as the probable potent candidates for learning and memory improvement.http://ibj.pasteur.ac.ir/article-1-2951-en.htmlandrogenscognitionhippocampusprotein kinase cspatial memory |
| spellingShingle | Sara Amiri Kayhan Azadmanesh Marzieh Dehghan Shasaltaneh Vafa Mayahi Nasser Naghdi The Implication of Androgens in the Presence of Protein Kinase C to Repair Alzheimer’s Disease-Induced Cognitive Dysfunction Iranian Biomedical Journal androgens cognition hippocampus protein kinase c spatial memory |
| title | The Implication of Androgens in the Presence of Protein Kinase C to Repair Alzheimer’s Disease-Induced Cognitive Dysfunction |
| title_full | The Implication of Androgens in the Presence of Protein Kinase C to Repair Alzheimer’s Disease-Induced Cognitive Dysfunction |
| title_fullStr | The Implication of Androgens in the Presence of Protein Kinase C to Repair Alzheimer’s Disease-Induced Cognitive Dysfunction |
| title_full_unstemmed | The Implication of Androgens in the Presence of Protein Kinase C to Repair Alzheimer’s Disease-Induced Cognitive Dysfunction |
| title_short | The Implication of Androgens in the Presence of Protein Kinase C to Repair Alzheimer’s Disease-Induced Cognitive Dysfunction |
| title_sort | implication of androgens in the presence of protein kinase c to repair alzheimer s disease induced cognitive dysfunction |
| topic | androgens cognition hippocampus protein kinase c spatial memory |
| url | http://ibj.pasteur.ac.ir/article-1-2951-en.html |
| work_keys_str_mv | AT saraamiri theimplicationofandrogensinthepresenceofproteinkinasectorepairalzheimersdiseaseinducedcognitivedysfunction AT kayhanazadmanesh theimplicationofandrogensinthepresenceofproteinkinasectorepairalzheimersdiseaseinducedcognitivedysfunction AT marziehdehghanshasaltaneh theimplicationofandrogensinthepresenceofproteinkinasectorepairalzheimersdiseaseinducedcognitivedysfunction AT vafamayahi theimplicationofandrogensinthepresenceofproteinkinasectorepairalzheimersdiseaseinducedcognitivedysfunction AT nassernaghdi theimplicationofandrogensinthepresenceofproteinkinasectorepairalzheimersdiseaseinducedcognitivedysfunction AT saraamiri implicationofandrogensinthepresenceofproteinkinasectorepairalzheimersdiseaseinducedcognitivedysfunction AT kayhanazadmanesh implicationofandrogensinthepresenceofproteinkinasectorepairalzheimersdiseaseinducedcognitivedysfunction AT marziehdehghanshasaltaneh implicationofandrogensinthepresenceofproteinkinasectorepairalzheimersdiseaseinducedcognitivedysfunction AT vafamayahi implicationofandrogensinthepresenceofproteinkinasectorepairalzheimersdiseaseinducedcognitivedysfunction AT nassernaghdi implicationofandrogensinthepresenceofproteinkinasectorepairalzheimersdiseaseinducedcognitivedysfunction |