The Role of Aryl Hydrocarbon Receptor in the Endothelium: A Systematic Review
Activation of the aryl hydrocarbon receptor (AhR) has been shown to be important in physiological processes other than detoxification, including vascular homeostasis. Although AhR is highly expressed in the endothelium, its function has been poorly studied. This systematic review aims to summarise c...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-08-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/24/17/13537 |
| _version_ | 1797582369716174848 |
|---|---|
| author | Sol Guerra-Ojeda Andrea Suarez Alicia Valls David Verdú Javier Pereda Elena Ortiz-Zapater Julián Carretero Maria D. Mauricio Eva Serna |
| author_facet | Sol Guerra-Ojeda Andrea Suarez Alicia Valls David Verdú Javier Pereda Elena Ortiz-Zapater Julián Carretero Maria D. Mauricio Eva Serna |
| author_sort | Sol Guerra-Ojeda |
| collection | DOAJ |
| description | Activation of the aryl hydrocarbon receptor (AhR) has been shown to be important in physiological processes other than detoxification, including vascular homeostasis. Although AhR is highly expressed in the endothelium, its function has been poorly studied. This systematic review aims to summarise current knowledge on the AhR role in the endothelium and its cardiovascular implications. We focus on endogenous AhR agonists, such as some uremic toxins and other agonists unrelated to environmental pollutants, as well as studies using AhR knockout models. We conclude that AhR activation leads to vascular oxidative stress and endothelial dysfunction and that blocking AhR signalling could provide a new target for the treatment of vascular disorders such as cardiovascular complications in patients with chronic kidney disease or pulmonary arterial hypertension. |
| first_indexed | 2024-03-10T23:20:11Z |
| format | Article |
| id | doaj.art-1e495fd153e74ea48fe6dafb927ae92a |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T23:20:11Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-1e495fd153e74ea48fe6dafb927ae92a2023-11-19T08:18:43ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-08-0124171353710.3390/ijms241713537The Role of Aryl Hydrocarbon Receptor in the Endothelium: A Systematic ReviewSol Guerra-Ojeda0Andrea Suarez1Alicia Valls2David Verdú3Javier Pereda4Elena Ortiz-Zapater5Julián Carretero6Maria D. Mauricio7Eva Serna8Department of Physiology, University of Valencia, 46010 Valencia, SpainDepartment of Physiology, University of Valencia, 46010 Valencia, SpainDepartment of Physiology, University of Valencia, 46010 Valencia, SpainDepartment of Physiology, University of Valencia, 46010 Valencia, SpainDepartment of Physiology, University of Valencia, 46010 Valencia, SpainBiomedical Research Institute INCLIVA, University of Valencia, 46010 Valencia, SpainDepartment of Physiology, University of Valencia, 46010 Valencia, SpainDepartment of Physiology, University of Valencia, 46010 Valencia, SpainDepartment of Physiology, University of Valencia, 46010 Valencia, SpainActivation of the aryl hydrocarbon receptor (AhR) has been shown to be important in physiological processes other than detoxification, including vascular homeostasis. Although AhR is highly expressed in the endothelium, its function has been poorly studied. This systematic review aims to summarise current knowledge on the AhR role in the endothelium and its cardiovascular implications. We focus on endogenous AhR agonists, such as some uremic toxins and other agonists unrelated to environmental pollutants, as well as studies using AhR knockout models. We conclude that AhR activation leads to vascular oxidative stress and endothelial dysfunction and that blocking AhR signalling could provide a new target for the treatment of vascular disorders such as cardiovascular complications in patients with chronic kidney disease or pulmonary arterial hypertension.https://www.mdpi.com/1422-0067/24/17/13537AhRendotheliumaortaendothelial functionvascular homeostasiscardiovascular system |
| spellingShingle | Sol Guerra-Ojeda Andrea Suarez Alicia Valls David Verdú Javier Pereda Elena Ortiz-Zapater Julián Carretero Maria D. Mauricio Eva Serna The Role of Aryl Hydrocarbon Receptor in the Endothelium: A Systematic Review International Journal of Molecular Sciences AhR endothelium aorta endothelial function vascular homeostasis cardiovascular system |
| title | The Role of Aryl Hydrocarbon Receptor in the Endothelium: A Systematic Review |
| title_full | The Role of Aryl Hydrocarbon Receptor in the Endothelium: A Systematic Review |
| title_fullStr | The Role of Aryl Hydrocarbon Receptor in the Endothelium: A Systematic Review |
| title_full_unstemmed | The Role of Aryl Hydrocarbon Receptor in the Endothelium: A Systematic Review |
| title_short | The Role of Aryl Hydrocarbon Receptor in the Endothelium: A Systematic Review |
| title_sort | role of aryl hydrocarbon receptor in the endothelium a systematic review |
| topic | AhR endothelium aorta endothelial function vascular homeostasis cardiovascular system |
| url | https://www.mdpi.com/1422-0067/24/17/13537 |
| work_keys_str_mv | AT solguerraojeda theroleofarylhydrocarbonreceptorintheendotheliumasystematicreview AT andreasuarez theroleofarylhydrocarbonreceptorintheendotheliumasystematicreview AT aliciavalls theroleofarylhydrocarbonreceptorintheendotheliumasystematicreview AT davidverdu theroleofarylhydrocarbonreceptorintheendotheliumasystematicreview AT javierpereda theroleofarylhydrocarbonreceptorintheendotheliumasystematicreview AT elenaortizzapater theroleofarylhydrocarbonreceptorintheendotheliumasystematicreview AT juliancarretero theroleofarylhydrocarbonreceptorintheendotheliumasystematicreview AT mariadmauricio theroleofarylhydrocarbonreceptorintheendotheliumasystematicreview AT evaserna theroleofarylhydrocarbonreceptorintheendotheliumasystematicreview AT solguerraojeda roleofarylhydrocarbonreceptorintheendotheliumasystematicreview AT andreasuarez roleofarylhydrocarbonreceptorintheendotheliumasystematicreview AT aliciavalls roleofarylhydrocarbonreceptorintheendotheliumasystematicreview AT davidverdu roleofarylhydrocarbonreceptorintheendotheliumasystematicreview AT javierpereda roleofarylhydrocarbonreceptorintheendotheliumasystematicreview AT elenaortizzapater roleofarylhydrocarbonreceptorintheendotheliumasystematicreview AT juliancarretero roleofarylhydrocarbonreceptorintheendotheliumasystematicreview AT mariadmauricio roleofarylhydrocarbonreceptorintheendotheliumasystematicreview AT evaserna roleofarylhydrocarbonreceptorintheendotheliumasystematicreview |