Diagnostic Value of Serum Procalcitonin and Diastolic Dysfunction for Evaluating the Mortality of Sepsis Patients Admitted in the Intensive Care
Background: Sepsis is a serious condition that can be fatal and has become more common in recent times. The impact of diastolic dysfunction on the early mortality rate of septic patients has not been extensively researched. This study aimed to assess the accuracy of serum procalcitonin (PCT) levels...
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2023-08-01
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| Series: | Archives of Anesthesia and Critical Care |
| Subjects: | |
| Online Access: | https://aacc.tums.ac.ir/index.php/aacc/article/view/660 |
| _version_ | 1797630511901835264 |
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| author | Mohammad Esmaeil Hejazi Ali Hossein Samadi Takaldani Abdolmohammad Ranjbar Mohammad Negaresh |
| author_facet | Mohammad Esmaeil Hejazi Ali Hossein Samadi Takaldani Abdolmohammad Ranjbar Mohammad Negaresh |
| author_sort | Mohammad Esmaeil Hejazi |
| collection | DOAJ |
| description |
Background: Sepsis is a serious condition that can be fatal and has become more common in recent times. The impact of diastolic dysfunction on the early mortality rate of septic patients has not been extensively researched. This study aimed to assess the accuracy of serum procalcitonin (PCT) levels and diastolic dysfunction in predicting the mortality rate of patients diagnosed with sepsis and admitted to the intensive care unit.
Methods: In this cross-sectional study, 40 sepsis patients admitted to the ICU were examined. Their characteristics were meticulously recorded using the APACHE II and SOFA score questionnaires, and only those who met the criteria underwent echocardiography. In order to evaluate the serum levels of PCT, it was required to take 40 ml of venous blood samples from the patients on the first and fifth days of admission.
Results: Out of 40 patients, the average age was 63±17 years. Of these patients, 23 (57.5%) were discharged, while 17 (42.5%) unfortunately passed away. Results showed a notable correlation between diastolic dysfunction, CRP, SOFA score on days 1 and 2, APACHE II score, and PCT on day 5 (P˂0.05). However, when analyzed using logistic regression, only PCT on day 5 showed a significant association with mortality.
Conclusion: Based on our research, we found that PCT is an essential indicator in predicting the mortality rate of sepsis patients. While there was no significant correlation between diastolic dysfunction and mortality, it should still be considered a critical factor in determining the mortality rate.
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| first_indexed | 2024-03-11T11:09:10Z |
| format | Article |
| id | doaj.art-1e4b0d6e1e784a4da31d36da98989dea |
| institution | Directory Open Access Journal |
| issn | 2423-5849 |
| language | English |
| last_indexed | 2024-03-11T11:09:10Z |
| publishDate | 2023-08-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Archives of Anesthesia and Critical Care |
| spelling | doaj.art-1e4b0d6e1e784a4da31d36da98989dea2023-11-12T06:52:25ZengTehran University of Medical SciencesArchives of Anesthesia and Critical Care2423-58492023-08-019Supplement10.18502/aacc.v9i5.13962Diagnostic Value of Serum Procalcitonin and Diastolic Dysfunction for Evaluating the Mortality of Sepsis Patients Admitted in the Intensive CareMohammad Esmaeil Hejazi0Ali Hossein Samadi Takaldani1Abdolmohammad Ranjbar2Mohammad Negaresh3Department of Internal Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.Department of Internal Medicine (Pulmonology Division), Ardabil University of Medical Sciences, Ardabil, Iran.Department of Cardiology, Tabriz University of Medical Sciences, Tabriz, Iran.Department of Internal Medicine, Ardabil University of Medical Sciences, Ardabil, Iran. Background: Sepsis is a serious condition that can be fatal and has become more common in recent times. The impact of diastolic dysfunction on the early mortality rate of septic patients has not been extensively researched. This study aimed to assess the accuracy of serum procalcitonin (PCT) levels and diastolic dysfunction in predicting the mortality rate of patients diagnosed with sepsis and admitted to the intensive care unit. Methods: In this cross-sectional study, 40 sepsis patients admitted to the ICU were examined. Their characteristics were meticulously recorded using the APACHE II and SOFA score questionnaires, and only those who met the criteria underwent echocardiography. In order to evaluate the serum levels of PCT, it was required to take 40 ml of venous blood samples from the patients on the first and fifth days of admission. Results: Out of 40 patients, the average age was 63±17 years. Of these patients, 23 (57.5%) were discharged, while 17 (42.5%) unfortunately passed away. Results showed a notable correlation between diastolic dysfunction, CRP, SOFA score on days 1 and 2, APACHE II score, and PCT on day 5 (P˂0.05). However, when analyzed using logistic regression, only PCT on day 5 showed a significant association with mortality. Conclusion: Based on our research, we found that PCT is an essential indicator in predicting the mortality rate of sepsis patients. While there was no significant correlation between diastolic dysfunction and mortality, it should still be considered a critical factor in determining the mortality rate. https://aacc.tums.ac.ir/index.php/aacc/article/view/660SepsisProcalcitoninC-Reactive ProteinLeft Ventricular Diastolic DysfunctionSOFAAPACHE |
| spellingShingle | Mohammad Esmaeil Hejazi Ali Hossein Samadi Takaldani Abdolmohammad Ranjbar Mohammad Negaresh Diagnostic Value of Serum Procalcitonin and Diastolic Dysfunction for Evaluating the Mortality of Sepsis Patients Admitted in the Intensive Care Archives of Anesthesia and Critical Care Sepsis Procalcitonin C-Reactive Protein Left Ventricular Diastolic Dysfunction SOFA APACHE |
| title | Diagnostic Value of Serum Procalcitonin and Diastolic Dysfunction for Evaluating the Mortality of Sepsis Patients Admitted in the Intensive Care |
| title_full | Diagnostic Value of Serum Procalcitonin and Diastolic Dysfunction for Evaluating the Mortality of Sepsis Patients Admitted in the Intensive Care |
| title_fullStr | Diagnostic Value of Serum Procalcitonin and Diastolic Dysfunction for Evaluating the Mortality of Sepsis Patients Admitted in the Intensive Care |
| title_full_unstemmed | Diagnostic Value of Serum Procalcitonin and Diastolic Dysfunction for Evaluating the Mortality of Sepsis Patients Admitted in the Intensive Care |
| title_short | Diagnostic Value of Serum Procalcitonin and Diastolic Dysfunction for Evaluating the Mortality of Sepsis Patients Admitted in the Intensive Care |
| title_sort | diagnostic value of serum procalcitonin and diastolic dysfunction for evaluating the mortality of sepsis patients admitted in the intensive care |
| topic | Sepsis Procalcitonin C-Reactive Protein Left Ventricular Diastolic Dysfunction SOFA APACHE |
| url | https://aacc.tums.ac.ir/index.php/aacc/article/view/660 |
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