The mechanism of metformin combined with total flavonoids of Rhizoma Drynariae on ovariectomy-induced osteoporotic rats

The mechanism of metformin combined with total flavonoids of Rhizoma Drynariae on ovariectomy-induced osteoporotic rats

The present study evaluated the in vitro effect of metformin (Met) and total flavonoids of Rhizoma Drynariae (TFRD) on osteoclasts, osteocytes, and osteoblasts at different stages. We also assessed the effect and mechanism of treatment with Met combined with TFRD on ovariectomy (OVX)-induced osteopo...

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Bibliographic Details
Main Authors: Ningning Jiang, Hui Jin, Kun Yang, Zhongyuan Zhang, Wenshu Xu, Xiaoxue Chen, Zhenhua Zhang, Hui Xu
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Metformin
Total flavonoids of Rhizoma Drynariae
Wnt/β-catenin
OPG/RANKL/RANK
Osteocyte
Osteoporosis
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223009721

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