BDNF/CREB signaling pathway contribution in depression pathogenesis: A survey on the non-pharmacological therapeutic opportunities for gut microbiota dysbiosis
Emerging evidence supports the gut microbiota and the brain communication in general health. This axis may affect behavior through modulating neurotransmission, and thereby involve in the pathogenesis and/or progression of different neuropsychiatric disorders such as depression. Brain-derived neurot...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-02-01
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| Series: | Brain Research Bulletin |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0361923024000157 |
| _version_ | 1797323748958797824 |
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| author | Somaieh Matin Masoomeh Dadkhah |
| author_facet | Somaieh Matin Masoomeh Dadkhah |
| author_sort | Somaieh Matin |
| collection | DOAJ |
| description | Emerging evidence supports the gut microbiota and the brain communication in general health. This axis may affect behavior through modulating neurotransmission, and thereby involve in the pathogenesis and/or progression of different neuropsychiatric disorders such as depression. Brain-derived neurotrophic factor and cAMP response element-binding protein known as CREB/BDNF pathway plays have critical functions in the pathogenesis of depression as the same of mechanisms related to antidepressants. However, the putative causal significance of the CREB/BDNF signaling cascade in the gut-brain axis in depression remains unknown. Also interventions such as probiotics supplementation and exercise can influence microbiome also improve bidirectional communication of gut and brain. In this review we aim to explain the BDNF/CREB signaling pathway and gut microbiota dysfunction and then evaluate the potential role of probiotics, prebiotics, and exercise as a therapeutic target in the gut microbiota dysfunction induced depression. The current narrative review will specifically focus on the impact of exercise and diet on the intestinal microbiota component, as well as the effect that these therapies may have on the microbiota to alleviate depressive symptoms. Finally, we look at how BDNF/CREB signaling pathway may exert distinct effects on depression and gut microbiota dysfunction. |
| first_indexed | 2024-03-08T05:33:40Z |
| format | Article |
| id | doaj.art-1e4e7ad9701a4265b02ec9dec588fe3f |
| institution | Directory Open Access Journal |
| issn | 1873-2747 |
| language | English |
| last_indexed | 2024-03-08T05:33:40Z |
| publishDate | 2024-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain Research Bulletin |
| spelling | doaj.art-1e4e7ad9701a4265b02ec9dec588fe3f2024-02-06T04:12:02ZengElsevierBrain Research Bulletin1873-27472024-02-01207110882BDNF/CREB signaling pathway contribution in depression pathogenesis: A survey on the non-pharmacological therapeutic opportunities for gut microbiota dysbiosisSomaieh Matin0Masoomeh Dadkhah1Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Digestive Diseases Research Center, Ardabil University of Medical Sciences, Ardabil, IranPharmaceutical Sciences Research center, Ardabil University of Medical Sciences, Ardabil, Iran; Corresponding author.Emerging evidence supports the gut microbiota and the brain communication in general health. This axis may affect behavior through modulating neurotransmission, and thereby involve in the pathogenesis and/or progression of different neuropsychiatric disorders such as depression. Brain-derived neurotrophic factor and cAMP response element-binding protein known as CREB/BDNF pathway plays have critical functions in the pathogenesis of depression as the same of mechanisms related to antidepressants. However, the putative causal significance of the CREB/BDNF signaling cascade in the gut-brain axis in depression remains unknown. Also interventions such as probiotics supplementation and exercise can influence microbiome also improve bidirectional communication of gut and brain. In this review we aim to explain the BDNF/CREB signaling pathway and gut microbiota dysfunction and then evaluate the potential role of probiotics, prebiotics, and exercise as a therapeutic target in the gut microbiota dysfunction induced depression. The current narrative review will specifically focus on the impact of exercise and diet on the intestinal microbiota component, as well as the effect that these therapies may have on the microbiota to alleviate depressive symptoms. Finally, we look at how BDNF/CREB signaling pathway may exert distinct effects on depression and gut microbiota dysfunction.http://www.sciencedirect.com/science/article/pii/S0361923024000157Microbiome-gut-brain axisDepressionCREB/BDNF signaling pathwayProbioticsPrebioticsExercise |
| spellingShingle | Somaieh Matin Masoomeh Dadkhah BDNF/CREB signaling pathway contribution in depression pathogenesis: A survey on the non-pharmacological therapeutic opportunities for gut microbiota dysbiosis Brain Research Bulletin Microbiome-gut-brain axis Depression CREB/BDNF signaling pathway Probiotics Prebiotics Exercise |
| title | BDNF/CREB signaling pathway contribution in depression pathogenesis: A survey on the non-pharmacological therapeutic opportunities for gut microbiota dysbiosis |
| title_full | BDNF/CREB signaling pathway contribution in depression pathogenesis: A survey on the non-pharmacological therapeutic opportunities for gut microbiota dysbiosis |
| title_fullStr | BDNF/CREB signaling pathway contribution in depression pathogenesis: A survey on the non-pharmacological therapeutic opportunities for gut microbiota dysbiosis |
| title_full_unstemmed | BDNF/CREB signaling pathway contribution in depression pathogenesis: A survey on the non-pharmacological therapeutic opportunities for gut microbiota dysbiosis |
| title_short | BDNF/CREB signaling pathway contribution in depression pathogenesis: A survey on the non-pharmacological therapeutic opportunities for gut microbiota dysbiosis |
| title_sort | bdnf creb signaling pathway contribution in depression pathogenesis a survey on the non pharmacological therapeutic opportunities for gut microbiota dysbiosis |
| topic | Microbiome-gut-brain axis Depression CREB/BDNF signaling pathway Probiotics Prebiotics Exercise |
| url | http://www.sciencedirect.com/science/article/pii/S0361923024000157 |
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