Anti‐tumor effects of a nonsteroidal anti‐inflammatory drug zaltoprofen on chondrosarcoma via activating peroxisome proliferator‐activated receptor gamma and suppressing matrix metalloproteinase‐2 expression

Anti‐tumor effects of a nonsteroidal anti‐inflammatory drug zaltoprofen on chondrosarcoma via activating peroxisome proliferator‐activated receptor gamma and suppressing matrix metalloproteinase‐2 expression

Abstract Surgical resection is the only treatment for chondrosarcomas, because of their resistance to chemotherapy and radiotherapy; therefore, additional strategies are crucial to treat chondrosarcomas. Peroxisome proliferator‐activated receptor gamma (PPARγ) is a ligand‐activated transcription fac...

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Bibliographic Details
Main Authors: Takashi Higuchi, Akihiko Takeuchi, Seiichi Munesue, Norio Yamamoto, Katsuhiro Hayashi, Hiroaki Kimura, Shinji Miwa, Hiroyuki Inatani, Shingo Shimozaki, Takashi Kato, Yu Aoki, Kensaku Abe, Yuta Taniguchi, Hisaki Aiba, Hideki Murakami, Ai Harashima, Yasuhiko Yamamoto, Hiroyuki Tsuchiya
Format: Article
Language:English
Published: Wiley 2018-05-01
Series:Cancer Medicine
Subjects:
Chondrosarcoma
MMP2
nonsteroidal anti‐inflammatory drugs
PPAR γ
zaltoprofen
Online Access:https://doi.org/10.1002/cam4.1438

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