The Role of Pyroptosis in Alzheimer's Disease
Pyroptosis is a type of regulated cell death that relies on caspases, vesicles, and the cleavage of gasdermin proteins (which create pores in the cell membrane). The nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome, which is involved in this process, is the most...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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IMR Press
2023-08-01
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| Series: | Journal of Integrative Neuroscience |
| Subjects: | |
| Online Access: | https://www.imrpress.com/journal/JIN/22/5/10.31083/j.jin2205129 |
| _version_ | 1797677870200389632 |
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| author | Yanxiu Ju Ling Zhao Songtao Li Qing Zhao |
| author_facet | Yanxiu Ju Ling Zhao Songtao Li Qing Zhao |
| author_sort | Yanxiu Ju |
| collection | DOAJ |
| description | Pyroptosis is a type of regulated cell death that relies on caspases, vesicles, and the cleavage of gasdermin proteins (which create pores in the cell membrane). The nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome, which is involved in this process, is the most widely studied inflammasome. Caspase-1 activates pro-inflammatory cytokines, such as IL-1β and IL-18. Gasdermin D (GSDMD) is the most important executive protein. GSDMD, a substrate rather than an upstream protease, determines the occurrence of pyroptosis. Pyroptosis is essential for maintaining body homeostasis, but excessive or poorly regulated cell death can aggravate the inflammatory response. Undoubtedly, this will be an important direction for future research on Alzheimer’s disease (AD). Here, we review recent research progress on the morphological characteristics, molecular mechanisms, and role of pyroptosis in the context of AD, thereby providing new directions for identifying potential disease biomarkers and treatment strategies for AD. |
| first_indexed | 2024-03-11T22:51:24Z |
| format | Article |
| id | doaj.art-1e5127e0d3cc43f690645b94a120ac87 |
| institution | Directory Open Access Journal |
| issn | 0219-6352 |
| language | English |
| last_indexed | 2024-03-11T22:51:24Z |
| publishDate | 2023-08-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Journal of Integrative Neuroscience |
| spelling | doaj.art-1e5127e0d3cc43f690645b94a120ac872023-09-22T02:49:15ZengIMR PressJournal of Integrative Neuroscience0219-63522023-08-0122512910.31083/j.jin2205129S0219-6352(23)00537-5The Role of Pyroptosis in Alzheimer's DiseaseYanxiu Ju0Ling Zhao1Songtao Li2Qing Zhao3Department of Neurology, China-Japan Union Hospital of Jilin University, 130031 Changchun, Jilin, ChinaDepartment of Neurosurgery, China-Japan Union Hospital of Jilin University, 130031 Changchun, Jilin, ChinaDepartment of Neurology, China-Japan Union Hospital of Jilin University, 130031 Changchun, Jilin, ChinaDepartment of Neurology, China-Japan Union Hospital of Jilin University, 130031 Changchun, Jilin, ChinaPyroptosis is a type of regulated cell death that relies on caspases, vesicles, and the cleavage of gasdermin proteins (which create pores in the cell membrane). The nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome, which is involved in this process, is the most widely studied inflammasome. Caspase-1 activates pro-inflammatory cytokines, such as IL-1β and IL-18. Gasdermin D (GSDMD) is the most important executive protein. GSDMD, a substrate rather than an upstream protease, determines the occurrence of pyroptosis. Pyroptosis is essential for maintaining body homeostasis, but excessive or poorly regulated cell death can aggravate the inflammatory response. Undoubtedly, this will be an important direction for future research on Alzheimer’s disease (AD). Here, we review recent research progress on the morphological characteristics, molecular mechanisms, and role of pyroptosis in the context of AD, thereby providing new directions for identifying potential disease biomarkers and treatment strategies for AD.https://www.imrpress.com/journal/JIN/22/5/10.31083/j.jin2205129alzheimer's diseasegasdermin dinflammasomepyroptosistherapy |
| spellingShingle | Yanxiu Ju Ling Zhao Songtao Li Qing Zhao The Role of Pyroptosis in Alzheimer's Disease Journal of Integrative Neuroscience alzheimer's disease gasdermin d inflammasome pyroptosis therapy |
| title | The Role of Pyroptosis in Alzheimer's Disease |
| title_full | The Role of Pyroptosis in Alzheimer's Disease |
| title_fullStr | The Role of Pyroptosis in Alzheimer's Disease |
| title_full_unstemmed | The Role of Pyroptosis in Alzheimer's Disease |
| title_short | The Role of Pyroptosis in Alzheimer's Disease |
| title_sort | role of pyroptosis in alzheimer s disease |
| topic | alzheimer's disease gasdermin d inflammasome pyroptosis therapy |
| url | https://www.imrpress.com/journal/JIN/22/5/10.31083/j.jin2205129 |
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