Mendelian randomization prioritizes abdominal adiposity as an independent causal factor for liver fat accumulation and cardiometabolic diseases
Gagnon et al. perform a Mendelian randomization study to investigate whether excess liver fat underpins adiposity’s effect on cardiometabolic disease risk. They show that abdominal adiposity strongly increases disease risk independently of liver fat, suggesting that targeting liver fat alone may not...
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Bibliographic Details
| Main Authors: |
Eloi Gagnon,
William Pelletier,
Émilie Gobeil,
Jérôme Bourgault,
Hasanga D. Manikpurage,
Ina Maltais-Payette,
Erik Abner,
Nele Taba,
Tõnu Esko,
Patricia L. Mitchell,
Nooshin Ghodsian,
Jean-Pierre Després,
Marie-Claude Vohl,
André Tchernof,
Sébastien Thériault,
Benoit J. Arsenault |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2022-10-01
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| Series: | Communications Medicine
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| Online Access: | https://doi.org/10.1038/s43856-022-00196-3
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