Mendelian randomization prioritizes abdominal adiposity as an independent causal factor for liver fat accumulation and cardiometabolic diseases
Gagnon et al. perform a Mendelian randomization study to investigate whether excess liver fat underpins adiposity’s effect on cardiometabolic disease risk. They show that abdominal adiposity strongly increases disease risk independently of liver fat, suggesting that targeting liver fat alone may not...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-10-01
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| Series: | Communications Medicine |
| Online Access: | https://doi.org/10.1038/s43856-022-00196-3 |
| _version_ | 1798029962829103104 |
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| author | Eloi Gagnon William Pelletier Émilie Gobeil Jérôme Bourgault Hasanga D. Manikpurage Ina Maltais-Payette Erik Abner Nele Taba Tõnu Esko Patricia L. Mitchell Nooshin Ghodsian Jean-Pierre Després Marie-Claude Vohl André Tchernof Sébastien Thériault Benoit J. Arsenault |
| author_facet | Eloi Gagnon William Pelletier Émilie Gobeil Jérôme Bourgault Hasanga D. Manikpurage Ina Maltais-Payette Erik Abner Nele Taba Tõnu Esko Patricia L. Mitchell Nooshin Ghodsian Jean-Pierre Després Marie-Claude Vohl André Tchernof Sébastien Thériault Benoit J. Arsenault |
| author_sort | Eloi Gagnon |
| collection | DOAJ |
| description | Gagnon et al. perform a Mendelian randomization study to investigate whether excess liver fat underpins adiposity’s effect on cardiometabolic disease risk. They show that abdominal adiposity strongly increases disease risk independently of liver fat, suggesting that targeting liver fat alone may not be sufficient to prevent cardiometabolic disease. |
| first_indexed | 2024-04-11T19:33:50Z |
| format | Article |
| id | doaj.art-1e515edb333a4daa9d17086f57f33806 |
| institution | Directory Open Access Journal |
| issn | 2730-664X |
| language | English |
| last_indexed | 2024-04-11T19:33:50Z |
| publishDate | 2022-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Medicine |
| spelling | doaj.art-1e515edb333a4daa9d17086f57f338062022-12-22T04:06:56ZengNature PortfolioCommunications Medicine2730-664X2022-10-01211910.1038/s43856-022-00196-3Mendelian randomization prioritizes abdominal adiposity as an independent causal factor for liver fat accumulation and cardiometabolic diseasesEloi Gagnon0William Pelletier1Émilie Gobeil2Jérôme Bourgault3Hasanga D. Manikpurage4Ina Maltais-Payette5Erik Abner6Nele Taba7Tõnu Esko8Patricia L. Mitchell9Nooshin Ghodsian10Jean-Pierre Després11Marie-Claude Vohl12André Tchernof13Sébastien Thériault14Benoit J. Arsenault15Centre de recherche de l’Institut universitaire de cardiologie et de pneumologie de QuébecCentre de recherche de l’Institut universitaire de cardiologie et de pneumologie de QuébecCentre de recherche de l’Institut universitaire de cardiologie et de pneumologie de QuébecCentre de recherche de l’Institut universitaire de cardiologie et de pneumologie de QuébecCentre de recherche de l’Institut universitaire de cardiologie et de pneumologie de QuébecCentre de recherche de l’Institut universitaire de cardiologie et de pneumologie de QuébecEstonian Genome Center, Institute of Genomics, University of TartuEstonian Genome Center, Institute of Genomics, University of TartuEstonian Genome Center, Institute of Genomics, University of TartuCentre de recherche de l’Institut universitaire de cardiologie et de pneumologie de QuébecCentre de recherche de l’Institut universitaire de cardiologie et de pneumologie de QuébecVITAM – Centre de recherche en santé durable, Université LavalSchool of Nutrition, Université LavalCentre de recherche de l’Institut universitaire de cardiologie et de pneumologie de QuébecCentre de recherche de l’Institut universitaire de cardiologie et de pneumologie de QuébecCentre de recherche de l’Institut universitaire de cardiologie et de pneumologie de QuébecGagnon et al. perform a Mendelian randomization study to investigate whether excess liver fat underpins adiposity’s effect on cardiometabolic disease risk. They show that abdominal adiposity strongly increases disease risk independently of liver fat, suggesting that targeting liver fat alone may not be sufficient to prevent cardiometabolic disease.https://doi.org/10.1038/s43856-022-00196-3 |
| spellingShingle | Eloi Gagnon William Pelletier Émilie Gobeil Jérôme Bourgault Hasanga D. Manikpurage Ina Maltais-Payette Erik Abner Nele Taba Tõnu Esko Patricia L. Mitchell Nooshin Ghodsian Jean-Pierre Després Marie-Claude Vohl André Tchernof Sébastien Thériault Benoit J. Arsenault Mendelian randomization prioritizes abdominal adiposity as an independent causal factor for liver fat accumulation and cardiometabolic diseases Communications Medicine |
| title | Mendelian randomization prioritizes abdominal adiposity as an independent causal factor for liver fat accumulation and cardiometabolic diseases |
| title_full | Mendelian randomization prioritizes abdominal adiposity as an independent causal factor for liver fat accumulation and cardiometabolic diseases |
| title_fullStr | Mendelian randomization prioritizes abdominal adiposity as an independent causal factor for liver fat accumulation and cardiometabolic diseases |
| title_full_unstemmed | Mendelian randomization prioritizes abdominal adiposity as an independent causal factor for liver fat accumulation and cardiometabolic diseases |
| title_short | Mendelian randomization prioritizes abdominal adiposity as an independent causal factor for liver fat accumulation and cardiometabolic diseases |
| title_sort | mendelian randomization prioritizes abdominal adiposity as an independent causal factor for liver fat accumulation and cardiometabolic diseases |
| url | https://doi.org/10.1038/s43856-022-00196-3 |
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