Effects of Hesperidin Supplementation on Anthropometric Indices in Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Background: Although some studies have reported that flavonoids can be associated with anti-obesity effects, the putative effects of hesperidin, as a subgroup of flavonoids, on anthropometric parameters are inconclusive. Therefore, this systematic review and meta-analysis of randomized controlled tr...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Shahid Sadoughi University of Medical Sciences and Health Services
2023-11-01
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| Series: | Journal of Nutrition and Food Security |
| Subjects: | |
| Online Access: | http://jnfs.ssu.ac.ir/article-1-606-en.pdf |
| _version_ | 1797524424436482048 |
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| author | Nahid Ramezani-Jolfaie Mojtaba Khademi Bafrooei Elnaz Lorzadeh Gholamali Javdan Farkhondeh Razmpour Alireza Shahab Jahanlou Amin Salehi-Abargouei Mohammad Mohammadi |
| author_facet | Nahid Ramezani-Jolfaie Mojtaba Khademi Bafrooei Elnaz Lorzadeh Gholamali Javdan Farkhondeh Razmpour Alireza Shahab Jahanlou Amin Salehi-Abargouei Mohammad Mohammadi |
| author_sort | Nahid Ramezani-Jolfaie |
| collection | DOAJ |
| description | Background: Although some studies have reported that flavonoids can be associated with anti-obesity effects, the putative effects of hesperidin, as a subgroup of flavonoids, on anthropometric parameters are inconclusive. Therefore, this systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to determine the effect of hesperidin supplementation on anthropometric measures in adults. Methods: A comprehensive literature search was performed until February 2022 in electronic databases such as PubMed, Scopus, Web of Science, and Google Scholar. The pooled results were obtained by a random-effects model. Results: A total of nine RCTs enrolling 493 participants were identified. Seven studies had illustrated the effect of hesperidin on weight, eight on body mass index (BMI), five on waist circumference (WC), two on waist to hip ratio (WHR), and two on hip circumference (HC). The results of the pooled analysis showed no significant changes in body weight (0.01 kg, 95% CI: -0.22, 0.24), BMI (-0.02 kg/m2, 95% CI: -0.16, 0.13), and WC (-0.48 cm, 95% CI: -1.52, 0.55) after hesperidin supplementation compared to the control group (P > 0.05). Qualitative assessment of other anthropometric indices also showed no beneficial effect of hesperidin in reducing WHR and HC values; however, these findings are not conclusive because of the limited number of studies. Conclusion: The present study provides no evidence that hesperidin supplementation is effective in improving anthropometric measures. More high-quality RCTs especially among overweight and obese individuals are needed to strengthen the evidence.
Corresponding Author:Mohammad Mohammadi
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| first_indexed | 2024-03-10T08:57:11Z |
| format | Article |
| id | doaj.art-1e52b503d5b54fc9a056993c01b843fa |
| institution | Directory Open Access Journal |
| issn | 2476-7417 2476-7425 |
| language | English |
| last_indexed | 2024-03-10T08:57:11Z |
| publishDate | 2023-11-01 |
| publisher | Shahid Sadoughi University of Medical Sciences and Health Services |
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| series | Journal of Nutrition and Food Security |
| spelling | doaj.art-1e52b503d5b54fc9a056993c01b843fa2023-11-22T07:02:09ZengShahid Sadoughi University of Medical Sciences and Health ServicesJournal of Nutrition and Food Security2476-74172476-74252023-11-0184694708Effects of Hesperidin Supplementation on Anthropometric Indices in Adults: A Systematic Review and Meta-Analysis of Randomized Controlled TrialsNahid Ramezani-Jolfaie0Mojtaba Khademi Bafrooei1Elnaz Lorzadeh2Gholamali Javdan3Farkhondeh Razmpour4Alireza Shahab Jahanlou5Amin Salehi-Abargouei6Mohammad Mohammadi7 Food Health Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran Department of Internal Medicine, School of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran School of Medicine, Faculty of Science, Medicine and Health, University of Wollongong, Wollongong, NSW 2522, Australia Food Health Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran Food Health Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran Cardiovascular Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran; Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Food Health Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran Background: Although some studies have reported that flavonoids can be associated with anti-obesity effects, the putative effects of hesperidin, as a subgroup of flavonoids, on anthropometric parameters are inconclusive. Therefore, this systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to determine the effect of hesperidin supplementation on anthropometric measures in adults. Methods: A comprehensive literature search was performed until February 2022 in electronic databases such as PubMed, Scopus, Web of Science, and Google Scholar. The pooled results were obtained by a random-effects model. Results: A total of nine RCTs enrolling 493 participants were identified. Seven studies had illustrated the effect of hesperidin on weight, eight on body mass index (BMI), five on waist circumference (WC), two on waist to hip ratio (WHR), and two on hip circumference (HC). The results of the pooled analysis showed no significant changes in body weight (0.01 kg, 95% CI: -0.22, 0.24), BMI (-0.02 kg/m2, 95% CI: -0.16, 0.13), and WC (-0.48 cm, 95% CI: -1.52, 0.55) after hesperidin supplementation compared to the control group (P > 0.05). Qualitative assessment of other anthropometric indices also showed no beneficial effect of hesperidin in reducing WHR and HC values; however, these findings are not conclusive because of the limited number of studies. Conclusion: The present study provides no evidence that hesperidin supplementation is effective in improving anthropometric measures. More high-quality RCTs especially among overweight and obese individuals are needed to strengthen the evidence. Corresponding Author:Mohammad Mohammadi View Orcid in Profile You can search for this author in PubMed Google Scholar Profilehttp://jnfs.ssu.ac.ir/article-1-606-en.pdfhesperidinbody weightanthropometrysystematic reviewmeta-analysis |
| spellingShingle | Nahid Ramezani-Jolfaie Mojtaba Khademi Bafrooei Elnaz Lorzadeh Gholamali Javdan Farkhondeh Razmpour Alireza Shahab Jahanlou Amin Salehi-Abargouei Mohammad Mohammadi Effects of Hesperidin Supplementation on Anthropometric Indices in Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Journal of Nutrition and Food Security hesperidin body weight anthropometry systematic review meta-analysis |
| title | Effects of Hesperidin Supplementation on Anthropometric Indices in Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials |
| title_full | Effects of Hesperidin Supplementation on Anthropometric Indices in Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials |
| title_fullStr | Effects of Hesperidin Supplementation on Anthropometric Indices in Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials |
| title_full_unstemmed | Effects of Hesperidin Supplementation on Anthropometric Indices in Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials |
| title_short | Effects of Hesperidin Supplementation on Anthropometric Indices in Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials |
| title_sort | effects of hesperidin supplementation on anthropometric indices in adults a systematic review and meta analysis of randomized controlled trials |
| topic | hesperidin body weight anthropometry systematic review meta-analysis |
| url | http://jnfs.ssu.ac.ir/article-1-606-en.pdf |
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