Critical role of lectin pathway mediated by MBL-associated serine proteases in complement activation for the pathogenesis in systemic lupus erythematosus
In complement activation system, although the classical pathway has shown to play a critical role for the pathogenesis of SLE, the role of lectin pathway has remained unknown in the pathogenesis of SLE. As Mannose-binding lectin-associated serine proteases (MASPs) are associated with activation of t...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-08-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023062801 |
| _version_ | 1797732840751759360 |
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| author | Yuko Asanuma Kazuhisa Nozawa Masakazu Matsushita Makio Kusaoi Yoshiyuki Abe Ken Yamaji Naoto Tamura |
| author_facet | Yuko Asanuma Kazuhisa Nozawa Masakazu Matsushita Makio Kusaoi Yoshiyuki Abe Ken Yamaji Naoto Tamura |
| author_sort | Yuko Asanuma |
| collection | DOAJ |
| description | In complement activation system, although the classical pathway has shown to play a critical role for the pathogenesis of SLE, the role of lectin pathway has remained unknown in the pathogenesis of SLE. As Mannose-binding lectin-associated serine proteases (MASPs) are associated with activation of the lectin pathway, we conducted this study to clarify MASPs associations in the pathogenesis of SLE. We evaluated the serum level of MASPs (MASP-1 and MASP-2) in total 68 SLE patients consisting of 15 patients with biopsy-confirmed membranous lupus nephritis (M-LN), 35 patients with biopsy-confirmed proliferative lupus nephritis (P-LN), and 18 SLE patients without LN (non-LN). Our data showed that the serum levels of MASPs were reduced in both P-LN and non-LN although those of M-LN were not reduced. Our data show that the lectin pathway mediated by MASPs plays a critical role for the pathogenesis of SLE except for M-LN. |
| first_indexed | 2024-03-12T12:20:21Z |
| format | Article |
| id | doaj.art-1e52d0f7c8e647f28030795c84393849 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-03-12T12:20:21Z |
| publishDate | 2023-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-1e52d0f7c8e647f28030795c843938492023-08-30T05:53:38ZengElsevierHeliyon2405-84402023-08-0198e19072Critical role of lectin pathway mediated by MBL-associated serine proteases in complement activation for the pathogenesis in systemic lupus erythematosusYuko Asanuma0Kazuhisa Nozawa1Masakazu Matsushita2Makio Kusaoi3Yoshiyuki Abe4Ken Yamaji5Naoto Tamura6Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan; Corresponding author. Department of Internal Medicine and Rheumatology, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.Department of Internal Medicine and Rheumatology, Juntendo University Koshigaya Hospital, Saitama, JapanDepartment of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, JapanDepartment of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, JapanDepartment of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, JapanDepartment of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, JapanDepartment of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, JapanIn complement activation system, although the classical pathway has shown to play a critical role for the pathogenesis of SLE, the role of lectin pathway has remained unknown in the pathogenesis of SLE. As Mannose-binding lectin-associated serine proteases (MASPs) are associated with activation of the lectin pathway, we conducted this study to clarify MASPs associations in the pathogenesis of SLE. We evaluated the serum level of MASPs (MASP-1 and MASP-2) in total 68 SLE patients consisting of 15 patients with biopsy-confirmed membranous lupus nephritis (M-LN), 35 patients with biopsy-confirmed proliferative lupus nephritis (P-LN), and 18 SLE patients without LN (non-LN). Our data showed that the serum levels of MASPs were reduced in both P-LN and non-LN although those of M-LN were not reduced. Our data show that the lectin pathway mediated by MASPs plays a critical role for the pathogenesis of SLE except for M-LN.http://www.sciencedirect.com/science/article/pii/S2405844023062801MASPsSystemic lupus erythematosusLupus nephritis |
| spellingShingle | Yuko Asanuma Kazuhisa Nozawa Masakazu Matsushita Makio Kusaoi Yoshiyuki Abe Ken Yamaji Naoto Tamura Critical role of lectin pathway mediated by MBL-associated serine proteases in complement activation for the pathogenesis in systemic lupus erythematosus Heliyon MASPs Systemic lupus erythematosus Lupus nephritis |
| title | Critical role of lectin pathway mediated by MBL-associated serine proteases in complement activation for the pathogenesis in systemic lupus erythematosus |
| title_full | Critical role of lectin pathway mediated by MBL-associated serine proteases in complement activation for the pathogenesis in systemic lupus erythematosus |
| title_fullStr | Critical role of lectin pathway mediated by MBL-associated serine proteases in complement activation for the pathogenesis in systemic lupus erythematosus |
| title_full_unstemmed | Critical role of lectin pathway mediated by MBL-associated serine proteases in complement activation for the pathogenesis in systemic lupus erythematosus |
| title_short | Critical role of lectin pathway mediated by MBL-associated serine proteases in complement activation for the pathogenesis in systemic lupus erythematosus |
| title_sort | critical role of lectin pathway mediated by mbl associated serine proteases in complement activation for the pathogenesis in systemic lupus erythematosus |
| topic | MASPs Systemic lupus erythematosus Lupus nephritis |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023062801 |
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