PD-L1 Blockade Differentially Impacts Regulatory T Cells from HIV-Infected Individuals Depending on Plasma Viremia.

PD-L1 Blockade Differentially Impacts Regulatory T Cells from HIV-Infected Individuals Depending on Plasma Viremia.

Blocking the PD-1/PD-L1 pathway has emerged as a potential therapy to restore impaired immune responses in human immunodeficiency virus (HIV)-infected individuals. Most reports have studied the impact of the PD-L1 blockade on effector cells and neglected possible effects on regulatory T cells (Treg...

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Bibliographic Details
Main Authors: Cristina Peligero, Jordi Argilaguet, Roberto Güerri-Fernandez, Berta Torres, Carmen Ligero, Pilar Colomer, Montserrat Plana, Hernando Knobel, Felipe García, Andreas Meyerhans
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-12-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC4669187?pdf=render

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