Maintenance therapy in acute myeloid leukemia after allogeneic hematopoietic stem cell transplantation
Abstract Relapse remains the main cause of treatment failure in acute myeloid leukemia (AML) undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT). Emerging evidence has demonstrated that AML patients might benefit from maintenance therapy post-transplantation, especially for hig...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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BMC
2021-01-01
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| Series: | Journal of Hematology & Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13045-020-01017-7 |
| _version_ | 1818418753974566912 |
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| author | Li Xuan Qifa Liu |
| author_facet | Li Xuan Qifa Liu |
| author_sort | Li Xuan |
| collection | DOAJ |
| description | Abstract Relapse remains the main cause of treatment failure in acute myeloid leukemia (AML) undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT). Emerging evidence has demonstrated that AML patients might benefit from maintenance therapy post-transplantation, especially for high-risk AML patients. In this mini-review, we will summarize targeted drugs, such as hypomethylating agents, FLT3 inhibitors and isocitrate dehydrogenase inhibitors, as maintenance therapy post-transplantation in AML patients undergoing allo-HSCT. |
| first_indexed | 2024-12-14T12:27:42Z |
| format | Article |
| id | doaj.art-1e5673c6e1e64a0f819c5c4ae7270e9a |
| institution | Directory Open Access Journal |
| issn | 1756-8722 |
| language | English |
| last_indexed | 2024-12-14T12:27:42Z |
| publishDate | 2021-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Hematology & Oncology |
| spelling | doaj.art-1e5673c6e1e64a0f819c5c4ae7270e9a2022-12-21T23:01:17ZengBMCJournal of Hematology & Oncology1756-87222021-01-011411810.1186/s13045-020-01017-7Maintenance therapy in acute myeloid leukemia after allogeneic hematopoietic stem cell transplantationLi Xuan0Qifa Liu1Department of Hematology, Nanfang Hospital, Southern Medical UniversityDepartment of Hematology, Nanfang Hospital, Southern Medical UniversityAbstract Relapse remains the main cause of treatment failure in acute myeloid leukemia (AML) undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT). Emerging evidence has demonstrated that AML patients might benefit from maintenance therapy post-transplantation, especially for high-risk AML patients. In this mini-review, we will summarize targeted drugs, such as hypomethylating agents, FLT3 inhibitors and isocitrate dehydrogenase inhibitors, as maintenance therapy post-transplantation in AML patients undergoing allo-HSCT.https://doi.org/10.1186/s13045-020-01017-7Maintenance therapyAcute myeloid leukemiaTargeted drugsAllogeneic hematopoietic stem cell transplantation |
| spellingShingle | Li Xuan Qifa Liu Maintenance therapy in acute myeloid leukemia after allogeneic hematopoietic stem cell transplantation Journal of Hematology & Oncology Maintenance therapy Acute myeloid leukemia Targeted drugs Allogeneic hematopoietic stem cell transplantation |
| title | Maintenance therapy in acute myeloid leukemia after allogeneic hematopoietic stem cell transplantation |
| title_full | Maintenance therapy in acute myeloid leukemia after allogeneic hematopoietic stem cell transplantation |
| title_fullStr | Maintenance therapy in acute myeloid leukemia after allogeneic hematopoietic stem cell transplantation |
| title_full_unstemmed | Maintenance therapy in acute myeloid leukemia after allogeneic hematopoietic stem cell transplantation |
| title_short | Maintenance therapy in acute myeloid leukemia after allogeneic hematopoietic stem cell transplantation |
| title_sort | maintenance therapy in acute myeloid leukemia after allogeneic hematopoietic stem cell transplantation |
| topic | Maintenance therapy Acute myeloid leukemia Targeted drugs Allogeneic hematopoietic stem cell transplantation |
| url | https://doi.org/10.1186/s13045-020-01017-7 |
| work_keys_str_mv | AT lixuan maintenancetherapyinacutemyeloidleukemiaafterallogeneichematopoieticstemcelltransplantation AT qifaliu maintenancetherapyinacutemyeloidleukemiaafterallogeneichematopoieticstemcelltransplantation |