EGFR deficiency leads to impaired self-renewal and pluripotency of mouse embryonic stem cells

EGFR deficiency leads to impaired self-renewal and pluripotency of mouse embryonic stem cells

Background Self-renewal and pluripotency are considered as unwavering features of embryonic stem cells (ESCs). How ESCs regulate the self-renewal and differentiation is a central question in development and regenerative medicine research. Epidermal growth factor receptor (EGFR) was identified as a c...

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Bibliographic Details
Main Authors: Miaoying Yu, Yinghui Wei, Kui Xu, Shasha Liu, Lei Ma, Yangli Pei, Yanqing Hu, Zhiguo Liu, Xue Zhang, Bingyuan Wang, Yulian Mu, Kui Li
Format: Article
Language:English
Published: PeerJ Inc. 2019-01-01
Series:PeerJ
Subjects:
Mouse embryonic stem cells
EGFR inhibition
AG1478
Pluripotency
Self-renewal
Online Access:https://peerj.com/articles/6314.pdf

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